Mechanism (Pathophysiology)

What is the underlying brain injury associated with concussion and what does it suggest about possible treatment?

The ICRP is conducting basic scientific studies on the neurobiology of concussion using innovative animal models. The basic scientists work closely with scientists involved in clinical research with human participants, to capitalize on basic science as a vital translational research platform for improving the diagnosis and care of concussion. 



Repeated Pediatric Concussions Evoke Long-Term Oligodendrocyte and White Matter Microstructural Dysregulation Distant from the Injury.

Lee JB, Affeldt BM, Gamboa Y, Hamer M, Dunn JF, Pardo AC, Obenaus A.

Dev Neurosci. 2018;40(4):358-375. doi: 10.1159/000494134. Epub 2018 Nov 22.


Utility of serum IGF-1 for diagnosis of growth hormone deficiency following traumatic brain injury and sport-related concussion.

Lithgow K, Chin A, Debert CT,Kline GA.

BMC Endocr Disord. 2018 Apr 2;18(1):20. doi: 10.1186/s12902-018-0247-1.