Research Publications

2024

N. Pourzadi and J. Gailer. The emerging application of LC-based metallomics techniques to unravel the bioinorganic chemistry of toxic metal(loid)s (Concept Paper). J. Chromatogr. A, 1736, 2024, 465409.https://authors.elsevier.com/sd/article/S0021-9673(24)00783-0  

N. Pourzadi and J. Gailer. L-cysteine mediated rapid separation of Hg²⁺ and MeHg⁺ by anion-exchange HPLC. J. Chromatogr. A, 1735, 2024, 465309. https://authors.elsevier.com/a/1jjNJ4-ggYqcq

M. Doroudian and J. Gailer. Interaction of carbonic anhydrase I released from red blood cells with human plasma in vitro. Metallomics, 16, 2024, mfae028. https://doi.org/10.1093/mtomcs/mfae028

M. Doroudian, N. Pourzadi, A. Gautam and J. Gailer. Translational toxicology of metal(loid) species: linking their bioinorganic chemistry in the bloodstream to organ damage onset. Biometals, 37, 2024, 739-753. https://link.springer.com/article/10.1007/s10534-023-00537-2

S. Geri, S. Zinnedu, L. Massai, L. Ronga, R. Lobinski, J. Gailer and L. Messori. Mercury binding to proteins disclosed by ESI-MS experiments: the case of three organomercurials. J. Inorg. Biochem. 252, 2024, 112479. https://doi.org/10.1016/j.jinorgbio.2024.112479

J. Gailer. Toward a mechanism-driven integrated framework to link human exposure to multiple toxic metal(loid) species with environmental diseases. Int. J. Mol. Sci. 25, 2024, 3393. https://doi.org/10.3390/ijms25063393

2023

M. Doroudian, M.E. Thibault and J. Gailer. N-acetylcysteine displaces glutathionyl-moieties from Hg²⁺ and MeHg⁺ to form more hydrophobic complexes at near-physiological conditions. Molecules 28, 2023, 6762. https://www.mdpi.com/1420-3049/28/19/6762

A. Gautam and J. Gailer. More effective mobilization of Hg²⁺ from human serum albumin compared to Cd²⁺ by L-cysteine at near-physiological conditions. Toxics 11, 2023, 599. https://www.mdpi.com/2305-6304/11/7/599

A. Gautam, A. Gomez, E. Mendoza Rengifo, G.N. George, I.J. Pickering and J. Gailer. Structural characterization of toxicologically relevant Cd²⁺-L-cysteine complexes. Toxics 11, 2023, 294. https://www.mdpi.com/2305-6304/11/4/294

2022

M. Doroudian and J. Gailer. Integrative metallomics studies of toxic metal(loid) substances at the blood plasma-red blood cell-organ/tumor nexus. Inorganics, 10, 2022, 200. https://www.mdpi.com/2304-6740/10/11/200

Environmental and Biochemical Toxicology: Concepts, Case Studies and Challenges (De Gruyter Textbook), Editors J. Gailer and R.J. Turner, 2022, https://www.amazon.com/Environmental-Biochemical-Toxicology-Concepts-Challenges/dp/3110626241

T.G. Bridle, M. Doroudian, W. White and J. Gailer. Physiologically relevant hCys concentrations mobilize MeHg from rabbit serum albumin to form MeHg-hCys complexes. Metallomics, 14, 2022, mfac010. https://academic.oup.com/metallomics/article-abstract/doi/10.1093/mtomcs/mfac010/6527585

S. Sarpong-Kumankomah, K.B. Knox, M.E. Kelly, G. Hunter, B. Popescu, H. Nichol, K. Kopciuk, H. Ntanda and J. Gailer. Quantification of human plasma metalloproteins in multiple sclerosis, ischemic stroke and healthy controls reveals an association of haptoglobin-hemoglobin complexes with age. PloS One 17, 2022, e0262160. https://doi.org/10.1371/journal.pone.0262160

2021

T.G. Bridle, P. Kumarathasan and J. Gailer. Toxic metals species and 'endogenous' metalloproteins at the blood-organ interface: analytical and bioinorganic aspects. Molecules 26, 2021, 3408. https://doi.org/10.3390/molecules26113408

A. Hill and J. Gailer. Linking molecular targets of Cd in the bloodstream to organ-based adverse health effects. J. Inorg. Biochem. 216, 2021, 111279. https://doi.org/10.1016/j.jinorgbio.2020.111279

S. Sarpong-Kumankomah and J. Gailer. Application of a novel metallomics tool to probe the fate of metal-based anticancer drugs in blood plasma: potential, challenges and prospects. Curr. Top. Med. Chem. 21, 2021, 48-58. 10.2174/1568026620666200628023540

K. Miller, S. Sarpong-Kumankomah, A. Egorov and J. Gailer. Sample Preparation enables baseline separation of iron metalloproteins by SEC-GFAAS. J. Chromatogr. B 1147, 2020, 122147. https://doi.org/10.1016/j.jchromb.2020.122147

S. Sarpong-Kumankomah, M. Contel and J. Gailer. SEC hyphenated to a multielement-specific detector unravels the degradation pathway of a bimetallic anticancer complex in human plasma. J. Chromatogr. B 1145, 2020, 122093. https://doi.org/10.1016/j.jchromb.2020.122093

S. Sarpong-Kumankomah, K. Miller and J. Gailer. Biological chemistry of toxic metals and metalloids, such as arsenic, cadmium and mercury.  Encyclopedia of Analytical Chemistry, 2006-2020, p 1-18, John Wiley & Sons, DOI: 10.1002/9780470027318.a9681