University of Calgary : Medical Science MDSC

Medical Science MDSC

MDSC 203 205 307 308 321 341 351 397 401 402 404 407 408 409 415 417 419 501 503 507 508 509 515 517 519 521 528 535 541 543 545 561 565 567 569 603 604 605 609 611 613 619 620 621 622 623 624 629 631 633 635 636 637 638 639 640 641 663 668 669 670 671 672 673 674 675 676 677 678 679 683 685 689 701 703 706 707 708 710 713 721 722 740 744 745 746 747 748 749 750 751 755

Instruction offered by members of the Cumming School of Medicine.

Students contemplating taking any of the undergraduate medical science courses are advised to contact the course co-ordinator(s) through the Undergraduate Sciences program office. Students contemplating taking any of the graduate-level (600 and up) Medical Science courses are advised to contact the course co-ordinator through the Graduate Science Education office.

Junior Courses

Medical Science 203

Developing Health Research Literacy I

Students will be introduced to the interdisciplinary scope of health research through reading and writing assignments. Students will learn the basics of academic research enquiry and practice academic writing and presentation skills through individual and team assignments.

Course Hours: 3 units; H(3-2T)
Prerequisite(s): Admission to the BHSc Honours program.

Medical Science 205

Developing Health Research Literacy II

Students will develop their critical thinking skills and their ability to write logically, well-argued research papers. Students will learn the fundamentals of logical reasoning as well as how to analyze theoretical issues in science, medicine, and philosophy.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Medical Science 203 and admission to the BHSc Honours program.

Senior Courses

Medical Science 307

Science, Philosophy and Society

A survey of underlying ideas concerning the objectives, methods, ambitions and responsibilities of the natural and social sciences.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Second year or higher in the BHSc Honours program or consent of the instructor.

Medical Science 308

Interdisciplinary Research Approaches

An introduction to the questions, methods and research techniques used across the different majors of Biomedical Sciences, Bioinformatics and Health and Society. Sessions will support the development of a broad perspective on health issues and introduce students to the history and the rules governing the ethical conduct of science and research on humans.
Course Hours: 6 units; F(6-0)
Prerequisite(s): Medical Science 205 and admission to the BHSc Honours program.

Medical Science 321

Introduction to Immunology

This introductory course is designed to expose students to the study of how the immune system encounters, recognizes, and responds to various infectious and pathogenic conditions. Emphasis will not solely focus on how components of the immune system interact with each other to generate an effective host response but also will be placed on how this immune response may be used to generate new therapies for human disease, how evolving and emerging pathogens interact with, and challenge the immune system, and how our knowledge of immunity has impacted society.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Biology 241 and 243.

Medical Science 341

Principles of Human Genetics

Introduction to principles in human genetics including Mendelian and chromosomal basis of inheritance, chromosomal abnormalities, pedigree analysis, mutations, and molecular, metabolic, population and clinical genetics. Studies of model organisms and genomics will be included as required. Incorporates problem-based learning to establish analytical skills in genetics.
Course Hours: 3 units; H(3-3T)
Prerequisite(s): Biology 241 and 243 or 231 and enrolment in the BHSc Honours program or consent of the instructor.
Antirequisite(s): Credit for Medical Science 341 and Biology 311 will not be allowed.

Medical Science 351

Honours Cellular and Molecular Biology

Introduction to principles in cellular and molecular biology. Emphasizes how structure underlies and determines function in the cell and how complex processes are organized and regulated at the molecular level.
Course Hours: 3 units; H(3-2T)
Prerequisite(s): Medical Science 341 and enrolment in the BHSc Honours program, or consent of the instructor.
Corequisite(s): Biochemistry 393.
Antirequisite(s): Credit for Medical Science 351 and Biology 331 will not be allowed.

Medical Science 397

Independent Studies in Health Sciences

Guided work fostering independent thought, practical research and the completion of written reports for first and second year BHSc students. After consultation with a Departmental faculty member who will supervise the chosen problem, an approval form obtained from the BHSc Office must be signed by the Associate Dean (UHSE) before a student can be registered.
Course Hours: 3 units; H(0-4)
Prerequisite(s): First or second year standing and consent of the BHSc Department.
MAY BE REPEATED FOR CREDIT

Medical Science 401

Bioinformatics

This introductory course will familiarize students with algorithms and computational techniques for bioinformatics applications. Topics to be covered include algorithm and search engines for the analysis of nucleic acid and protein sequences and structures; machine learning techniques for biological data analysis; systems biology approaches for computational modelling.
Course Hours: 3 units; H(3-0)
Prerequisite(s): 6 units (1.0 full-course equivalent) in Computer Science at the 300 level or Medical Science 341 and 351 or 6 units (1.0 full-course equivalent) in Biological Sciences at the 300 level or consent of the instructor.

Medical Science 402

Organismal Biology

Organismal structure from the cellular to the organism level focusing on vertebrates with a particular emphasis on humans. Topics covered include cell biology, histology, vertebrate development and anatomy. This course is inquiry-based and will consist of lectures, small group sessions and interactive laboratory sessions.
Course Hours: 6 units; F(3-3)
Prerequisite(s): Enrolment in the BHSc Honours program, Biology 241 and 243, or 231, and Medical Science 351, or consent of the instructor.
Antirequisite(s): Credit for Medical Science 402 and 417 will not be allowed.
Notes: Course cannot be taken concurrently with Medical Science 508.

Medical Science 404

Integrative Human Physiology

Physiology is defined as the study of how living organisms function and encompasses the integration of processes from molecules to the whole-organism. Provides fundamental principles and concepts about the physiology of the major human organ systems. Each unit is co-ordinated and taught by published scholars.
Course Hours: 6 units; F(3-3T)
Prerequisite(s): Enrolment in the BHSc Honours program or consent of the instructor.
Antirequisite(s): Credit for Medical Science 404 and any of Kinesiology 259, 260, 323, Zoology 269, 461 or 463 will not be allowed.

Medical Science 407

Statistics and Research Design in Health Sciences

An introduction to the study of research design and statistical analysis including a broad overview of the variety of methods for research in health sciences. Students will be introduced to a variety of research tools through lecture and tutorial components.
Course Hours: 3 units; H(3-2)
Prerequisite(s): Enrolment in the BHSc Honours program.

Medical Science 408

Research Design in Molecular Biology and Bioinformatics

An introduction to the research methods utilized in the Health Sciences. Students will begin to develop the knowledge and skills necessary to conduct research in their respective fields. The importance of research design, qualitative, quantitative and mixed methods and the theoretical constructs that inform these approaches will be emphasized.
Course Hours: 6 units; F(6-0)
Prerequisite(s): Medical Science 308 and admission to the BHSc Honours program.

Medical Science 409

Brain and Society

Topics will include neuronal mechanisms of addiction, neuronal mechanisms of learning and memory, aging in the human brain and behavioural consequences and mind/brain dichotomy.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Enrolment in the BHSc Honours program.

Medical Science 415

Introduction to Epidemiology

An introduction to the basic concepts of epidemiology needed to understand and critically analyze research pertaining to health and disease in populations. Methods used in descriptive and analytic epidemiological studies, including the design, analysis and interpretation of results for observational studies and clinical trials will be discussed. Case studies and contemporary events will be used to illustrate epidemiology in action and to highlight the social aspects of applying epidemiology in public health.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Medical Science 308 or consent of the instructor.

Medical Science 417

Integrated Research Course I

Provides students with the basic conceptual framework, knowledge and skill set to work and think independently in a medical science or life science research environment in their topic area. The course will include lectures in the various topic areas, group sessions and self-directed research project in the topic area.

417.01. Genetics I

417.02. Microbiology, Immunology and Infection I

417.03. Cardiovascular Sciences I

417.04. Cancer Biology I

417.05. Biochemistry and Molecular Biology I

417.06. Pharmacology and Physiology I

417.07. Neuroscience I

417.08. Special Topics I

Course Hours: 3 units; H(3-3)
Prerequisite(s): Medical Science 308 and enrolment in the BHSc Honours program, or consent of the instructor.
Antirequisite(s): Credit for Medical Science 417 and 402 will not be allowed.
Notes: Course needs to be taken in combination with the corresponding Medical Science 419 integrated research course II in the same academic year. Course cannot be taken concurrently with Medical Science 508.

Medical Science 419

Integrated Research Course II

Provides students with the basic conceptual framework, knowledge and skill set to work and think independently in a medical science or life science research environment in their topic area. The course will be a continuation of the courses topic areas, and will for the most part consist of the self-directed laboratory research project started in the topic area in Medical Science 417.

419.01. Genetics II

419.02. Microbiology, Immunology and Infection II

419.03. Cardiovascular Sciences II

419.04. Cancer Biology II

419.05. Biochemistry and Molecular Biology II

419.06. Pharmacology and Physiology II

419.07. Neuroscience II

419.08. Special Topics II

Course Hours: 3 units; H(0-6)
Prerequisite(s): Medical Science 308, the appropriate 417 course and enrolment into to the BHSc Honours program or consent of the instructor.
Antirequisite(s): Credit for Medical Science 419 and 402 will not be allowed.
Notes: Course needs to be taken in combination with the corresponding Medical Science 417 Integrated Research Course I in the same academic year.

Medical Science 501

Principles and Mechanisms of Pharmacology

Basic principles of pharmacology, with specific emphasis on receptor signaling mechanisms.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Enrolment in the BHSc Honours program, Biochemistry 443, and one of Zoology 461, 463, or Medical Science 404, or consent of the instructor.
Also known as: (Biology 501)

Medical Science 503

Pharmacology of Organ Systems

Pharmacology of the nervous, cardiovascular, renal and immune systems, as well as anti-cancer therapies. Principles of toxicology.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Medical Science 501 (Biology 501) or consent of the Faculty.
Also known as: (Biology 503)

Medical Science 507

Special Problems in Medical Science

Lectures, seminars, term papers and training in theoretical and/or laboratory methods. After consultation with a faculty member who will supervise the chosen problem, an approval form obtained from the BHSc Office must be signed by the Associate Dean (UHSE) before a student can be registered.
Course Hours: 3 units; H(3-3)
Prerequisite(s): Consent of the BHSc Honours Program.
MAY BE REPEATED FOR CREDIT

Medical Science 508

Honours Thesis and Research Communication

Capstone research course in the BHSc to be conducted through any one of the basic research departments. Students would be expected to conduct research. Course also involves weekly small group sessions aimed at building research communication skills. Course culminates with submission of a written thesis that is presented and defended in front of a panel of faculty members in an oral examination.
Course Hours: 12 units; 2xF(0-6)
Prerequisite(s): Enrolment in the BHSc Honours program and Health and Society 408 or Medical Science 408 and a minimum cumulative 3.30 GPA or consent of the director.
Notes: This course is worth 12 units (2.0 full-course equivalents) and is offered over two sessions. Course cannot be taken concurrently with Medical Science 402, 417 or 419.

Medical Science 509

Proteomics

An introductory course to familiarize students with techniques used for protein identification and proteome analysis, including one and two-dimensional gel electrophoresis, mass spectrometry and the databases and search engines used in the identification of expressed proteins.
Course Hours: 3 units; H(3-3)
Prerequisite(s): Biochemistry 443 and Medical Sciences 351 or Biology 331.

Medical Science 515

Cellular Mechanisms of Disease

The cellular and molecular mechanisms underlying basic human disease processes and how these can be influenced by lifestyle and environmental factors. The ways in which this knowledge can be used in the laboratory diagnosis of disease.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Biochemistry 443 and one of Biology 331 or Medical Science 351.
Also known as: (Biology 515)

Medical Science 517

Introduction to Biotechnology Business and Profession

An overview of the biotechnology sector from several perspectives: product development, regulatory, intellectual property, market analysis, and finance. This course will include two modules. The first is a series of lectures by faculty and local entrepreneurs to provide the necessary background for the assignments in the second module. The second module will include student-selected case studies and an analysis of a small biotechnology company.
Course Hours: 3 units; H(3-1T)
Prerequisite(s): Medical Science 351 or consent of the instructor.

Medical Science 519

Advanced Bioinformatics

Designed to develop student ability to perform bioinformatics analyses of datasets and develop their knowledge of the current literature. The course will emphasize careful study of recent methodologies for chromatin immunoprecipitation followed by sequencing (ChIP-seq) dataset analysis. The course will include lectures, literature review sessions and a self-directed bioinformatics research project.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Medical Science 401 and at least one of Computer Science 217, 219, 231 or 233; or consent of the instructor.

Medical Science 521

Human Anatomy

An inquiry-based exploration of clinically significant human anatomy. The course will follow a systems-based approach, and will make use of multiple learning formats. Each week, the instructor will lead classroom and laboratory sessions that explore an anatomical system from developmental, functional, and clinical perspectives.
Course Hours: 3 units; H(3-3)
Prerequisite(s): Fourth year standing in the BHSc program or consent of the instructor.

Medical Science 528

Independent Studies in Medical Science

Original and independent thought, practical research and the completion of written and oral reports. After consultation with a faculty member who will supervise the chosen problem, an approval form obtained from the BHSc Office must be signed by the Associate Dean (UHSE) before a student can be registered.
Course Hours: 6 units; F(0-6)
Prerequisite(s): Consent of the BHSc Department.
MAY BE REPEATED FOR CREDIT

Medical Science 535

Psychosocial Oncology

Focuses on developing the understanding in health care practitioners of the central concepts related to caring for cancer patients and their families.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Consent of the instructor.
Antirequisite(s): Credit for Medical Science 535 and 635 will not be allowed.

Medical Science 541

Advanced Genetics I

Historical papers will illustrate the foundations of modern genetic principles. Topics including the chromosomal theory of inheritance, the role of pairing and recombination for chromosomal disjunction during meiosis, cytogenetics, the nature of dominant mutations, genetic screens and genetics analysis of developmental pathways. Material covered is drawn from model organisms and humans.
Course Hours: 3 units; H(3-1T)
Prerequisite(s): Medical Science 341 or Biology 311 or consent of the instructor.

Medical Science 543

Advance Genetics II

An advanced course in molecular genetic analysis. Topics will vary from year to year, but may include identification of the structure, transmission, mutation and molecular pathology of human genes, the use of experimental organisms (chick, fish, fly, mouse, worm) to model human genetic diseases, and molecular studies of human populations and evolution. The focus will be upon applied molecular genetics with recurring emphasis on the theme of relevance to issues in health and society.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Medical Science 341 or Biology 311, and Medical Science 402 or consent of the instructor.
Notes: Previous completion of Medical Science 541 is suggested but not required.

Medical Science 545

Genomics

Examine the strategies and techniques, including massively parallel sequencing, used in genomic and genetic studies. Review how model systems and genome editing are used to establish the functional consequences of genomic variation. Students can expect to gain a comprehensive understanding and broad appreciation of the significance of genomic information in context of rare and common human diseases, and genome biology.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Medical Science 408 or Cellular, Molecular and Microbial Biology 413 or consent of the instructor.

Medical Science 561

Cancer Biology

Advances in methodology and in theoretical concepts have permitted continuing breakthroughs in our understanding of the organismal, cellular and molecular biology of cancer cells, and in the development of novel strategies for cancer prevention, diagnosis and treatment. These advances will be presented in a comprehensive overview of cancer including issues of demographics and incidence, causation and detection, origins and progression and therapeutic approaches. Emphasis will be placed on the cell and molecular biology of cancer and on the interaction of the cancer cell with the host organism.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Biochemistry 443, Medical Science 351 or Biology 331, and Cellular, Molecular and Microbial Biology 411.
Also known as: (Cellular, Molecular and Microbial Biology 561)

Medical Science 565

Advanced Topics in Pathogenic Microbiology

Provides a fuller understanding of bacterial diseases using a systems approach and illustrating key paradigms via the consideration of specific pathogens. Topics include: strategies for bacteria surviving host immune responses, bacterial invasion strategies, opportunistic infections, disease Pathogenesis, and antibiotic resistance, challenges of dealing with emerging infections. Lectures, small group interactive sessions, specified readings.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Cellular, Molecular and Microbial Biology 343 and 431.
Also known as: (Cellular, Molecular and Microbial Biology 565)

Medical Science 567

Advanced Topics In Immunology

New and emerging themes in immunology, with an emphasis on disease processes such as inflammation in the gut, kidney and lung. Topics include: innate immunity, the inflammasome, sterile inflammation, process and mechanism of immune cell recruitment in different tissues, T cell biology, B cell biology, regulatory immune cells, mucosal immunity, airways responses to virus, mechanisms of food allergies, inflammatory bowel disease. Lectures, small group interactive sessions, specified readings.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Cellular, Molecular and Microbial Biology 527 or Medical Science 321.
Also known as: (Cellular, Molecular and Microbial Biology 567)

Medical Science 569

Advanced Topics in Physiology

Designed for undergraduates with a general understanding of human physiology who wish to pursue advanced topics in a physiological system(s). The physiological system offered will vary from year to year and students should contact the instructor for more information prior to enrolling in the course. There will be a review and then build on basic physiological principles through a series of lectures and/or discussion groups. An examination of the specified area of physiology in-depth by introducing students to research methodologies and pathological processes.
Course Hours: 3 units; H(3-1T)
Prerequisite(s): Medical Science 404 or Zoology 463 or consent of the instructor.
MAY BE REPEATED FOR CREDIT

Graduate Courses

Medical Science 603

Biology of Laboratory Animals

Based on the Canadian Council of Animal Care Syllabus "Basic Principles of Laboratory Animal Science for Research Scientists." In addition to the study of common, research, farm and exotic animals, topics covered include ethical considerations, regulation and legislation, animal models, animal facilities and husbandry, hazard control, surgery, anaesthesiology, euthanasia and post-mortem examinations. Practical sessions will provide experience in handling and restraint of specific laboratory animals, injections, blood collection, anaesthesiology and surgery.
Course Hours: 3 units; H(3-1)
Prerequisite(s): Consent of the Faculty.
Notes: Enrolment in this course is restricted to graduate students who will do research utilizing animals.
Also known as: (Biology 603)

Medical Science 604

Integrative Human Physiology

Physiology is the study of how living organisms function and encompasses the integration of processes from molecules to the whole-organism. Designed to provide the student with fundamental principles and concepts about the normal function of the major human organ systems. At the end of this course, the student should be well equipped to apply their acquired knowledge to solve complex physiological problems related to integrative human physiology.
Course Hours: 6 units; F(3-3)
Prerequisite(s): Consent of the Faculty.

Medical Science 605

Information Storage and Processing in Biological Systems

Examination of complex biological systems; concepts and fundamentals of biological solutions to information storage and processing: modelling and computer simulation of biological systems; information storage in biological molecules; genetic networks; hierarchical organization of biological information processing in signal transduction, development, evolution, and ecology; biological control systems.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Consent of the Faculty.
Also known as: (Computer Science 605)

Medical Science 609

Gene Expression

The flow of genetic information from DNA to final protein product. Gene structure and regulation of transcription, including gene structure and organization, chromatin structure, regulation of transcription and post-translational processing; and the activity of genes during development including stored messenger ribonucleoprotein particles and translational control in gametes, the switch from maternal to zygote genome control of development in early embryos and the molecular basis of morphogenesis and differentiation.

609.02. Genes and Development

Course Hours: 3 units; H(3-0)
Prerequisite(s): Medical Science 537 (Biochemistry 537) and consent of the Faculty.
Antirequisite(s): Credit for Medical Science 609.02 and 751.14 will not be allowed.

Medical Science 611

Medical Microbiology

The basic principles of medical microbiology and the pathogenesis of infectious disease and of clinically important microbial pathogens including bacteria, viruses, parasites and fungi. Recent concepts will be described and students will be expected to present and critically discuss research advances of their choosing from the current research literature.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Cellular, Molecular and Microbial Biology 343 or consent of the Faculty.
Also known as: (formerly Medical Science 612)

Medical Science 613

Advanced Studies in Microbiology

Specialized topics including basic principles of infection; spread, prevention and control of infectious diseases; mechanisms of and approaches to study bacterial pathogenesis; mechanism, methodology and modelling of gene expression.

613.01. Epidemiology of Infectious Diseases

613.02. Pathogenesis of Microbial Disease

613.05. Regulation of Gene Expression in Bacteria

Course Hours: 3 units; H(3-0)
Prerequisite(s): Medical Science 612 or Cellular, Molecular and Microbial Biology 421 or 521 or consent of the Faculty.

Medical Science 619

Neurosciences

Introductory neuroscience courses covering aspects of cellular, molecular, and systems physiology, neuroanatomy, and neurodevelopment.

619.01. Cellular, Molecular and Developmental Neuroscience

619.02. Systems Neuroscience and Neuropathology

Course Hours: 3 units; H(4-2)
Prerequisite(s): Must be registered in the Neuroscience Graduate Program. Consent of instructor(s) is required for all other students.
Notes: Not open to undergraduate students.

Medical Science 620

Topics in Systems Physiology

Designed for students undertaking research in physiology or related disciplines with only limited prior exposure to the discipline. Introduces and discusses fundamental and current issues in physiology ranging from the basic physiological systems through to translational clinical topics. Encompasses the basic physiological mechanisms with emphasis on the role of the autonomic nervous system. Subject areas will include basic physiology of the cardiovascular, respiratory, gastrointestinal, renal, endocrine and reproductive systems.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Consent of the Faculty.

Medical Science 621

Principles of Drug Action

The action of chemicals and drugs on biological systems ranging from subcellular particles to the intact organism.

621.01. Basic Principles of Pharmacology

Course Hours: 3 units; H(3-0)
Prerequisite(s): Zoology 461, Medical Science 404 and Medical Science/Biology 501, or consent of the Faculty.

Medical Science 622

Neurobiology of Mental Illness

Students are exposed to up-to-date research regarding the neurobiological theories of various mental illnesses (such as depression, anxiety disorders, schizophrenia, etc.). The seminar format will involve discussion in both research and review articles. The focus of discussion will be on both preclinical research and clinical studies that shed insight into the neurobiology of mental illnesses or their treatments.
Course Hours: 3 units; H(3S-0)
Prerequisite(s): Medical Science 619.02 and registration in a Cumming School of Medicine graduate program. Consent of instructor is required for all other students.
Notes: Open to Psychology graduate students and Psychiatry residents with consent of instructor.

Medical Science 623

Respiratory Science and Critical Illness

Respiratory physiology;including topics such as cellular, morphology, mechanics, control of breathing, and respiratory muscles, necessary to an understanding of respiration and respiratory failure. As well, core physiology and molecular biology underlying critical illness.

623.01. Pulmonary Mechanics and Gas Exchange

623.02. Physiology of Respiration and Critical Illness

623.03. Respiratory Science: Basic

623.04. Respiratory Science: Applied

Course Hours: 3 units; H(3-1T)
Prerequisite(s): Zoology 463 or 465 or consent of the Faculty.

Medical Science 624

Neuroanatomy

Detailed introduction to neuroanatomy using Homo sapiens as the primary experimental species but relying on other vertebrates for additional details. Detailed anatomic aspects of each major brain region, along with major connections and functions related to those regions will be presented. Laboratories will examine gross specimens, virtual microscopic images, and other anatomic images.
Course Hours: 3 units; H(2-2)
Prerequisite(s): Medical Science 619.02 or consent of the instructor.
Also known as: (formerly Medical Science 751.42)

Medical Science 629

Cardiovascular Dynamics

Includes topics such as basic physiologic mechanisms including excitation-contraction coupling, mechanics, energetics, and cardiovascular control; major diseases entities as a means of illustrating pathologic alterations in normal physiologic mechanisms; or a systematic in-depth examination of the chemicals that affect the cardiovascular system.

629.01. Cardiovascular Physiology

629.02. Cardiovascular Pathophysiology

629.03. Cardiovascular Pharmacology

Course Hours: 3 units; H(3-0)
Prerequisite(s): Consent of the Faculty.

Medical Science 631

Muscle Physiology

Contractile processes, excitation-contraction coupling, the control of contraction and energetics in smooth, cardiac and skeletal muscle. Molecular studies of the contractile process and of the process of excitation contraction coupling.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Consent of the Faculty.

Medical Science 633

The Kidney

Advanced courses detailing the functional organization of the kidney at all levels, from cell to intact organism. Topics encompass basic physiological principles and their relevance to experimental medicine and therapeutics, as well as the study of disease processes, which impact kidney function.

633.01. Renal Physiology

633.02. Renal Pathophysiology

633.03 History of Renal Physiology

Course Hours: 3 units; H(3-0)
Prerequisite(s): Medical Science 604 or consent of the Faculty.

Medical Science 635

Psychosocial Oncology

A seminar-based course focusing on the possible causes of psychosocial problems in cancer patients and families (medical, psychological and social) and also on how patients and families are helped through the difficult transitions resulting from a cancer diagnosis, treatment, recurrent disease, and end of life care.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Consent of the Faculty.
Antirequisite(s): Credit for Medical Science 635 and 535 will not be allowed.
Notes: This course is open to health professionals and researchers, and to advanced undergraduate students in relevant disciplines.

Medical Science 636

Advanced Topics in Physiology

Provides a general understanding in physiological systems and will present advanced topics in specified physiological system(s) for further depth of understanding. Review and build on basic physiological principles through a series of lectures and discussion groups and will examine a specified area of physiology in-depth by introducing students to research methodology and pathological processes in the system.
Course Hours: 3 units; H(3-1T)
Prerequisite(s): Medical Science 404 or Zoology 463 or consent of the instructor.
Antirequisite(s): Credit for Medical Science 569 and Medical Science 636 will not be allowed.

Medical Science 637

Gastrointestinal Physiology

Physiology of the gastrointestinal (GI) tract at all levels from the cell to the intact system. Medical Science 637.01 has three components: 1) An introductory series of lectures covering the basic physiological principles of the regulation of the GI tract and the individual organs that comprise it or are associated with it; 2) Extended directed tutorials conducted online through D2L. Topics will be selected to reflect the needs and interests of the enrolled students; 3) A written term paper on a subject of the students' own choice and pre-approved by the course co-ordinator that will also be presented orally to the class.

637.01. Organization and Function of the GI Tract

Course Hours: 3 units; H(3-0)
Prerequisite(s): Consent of the Faculty.

Medical Science 638

Mucosal Pathophysiology

Focuses on the physiology and pathophysiology of the gastrointestinal tract, lung and other mucosal tissues. A particular emphasis will be placed on inflammatory processes in these tissues, and how they contribute to symptom generation and tissue dysfunction. Involves independent research on the part of the students, small group sessions, written assignments and class presentations
Course Hours: 3 units; H(4-0)
Prerequisite(s): Consent of the Faculty.

Medical Science 639

Immunology

Introductory and advanced courses in immunology that cover humoral and cellular immunity and the inflammatory response at the cellular, molecular, and whole organism level. Basic mechanisms that lead to immunity or to inflammatory responses. The contribution of immunological and inflammatory processes in the immunopathogenesis of disease.

639.02. Cellular and Molecular Immunology

639.04. Inflammation

Course Hours: 3 units; H(3-0)
Prerequisite(s): Consent of the Faculty.

Medical Science 640

Introduction to Immunology

Introductory immunology for graduate students who have no background in immunology in their undergraduate studies. It provides a comprehensive overview of the immune responses: antibody-antigen interaction, antibody structure, genetics and synthesis, cellular immunology, MHC, phagocytosis, and tolerance. Using this basic understanding of fundamental immune processes the involvement of the immune response in autoimmunity, hypersensitivity, tissue rejection, tumor immunology, vaccine production, viral, bacterial, fungal and parasitic infections will be discussed. Additionally, methods for the study of immunology will be covered.
Course Hours: 3 units; H(3-1T)
Prerequisite(s): Consent of the Faculty.
Antirequisite(s): Credit for Medical Science 640 and Cellular, Molecular and Microbial Biology 527 will not be allowed.
Notes: This course will share lectures with Cellular, Molecular and Microbial Biology 527 with an additional separate tutorial.

Medical Science 641

Genetics

Advanced courses that provide in-depth coverage of the research discipline of genetics, including the areas of cytogenetics, genomics, metabolic genetics, mouse genetics, population genetics, and human and medical genetics.

641.01. Advanced Genetics I

641.02. Advanced Human Cytogenetics

641.03. Advanced Genetics II

641.04. Genomics

Course Hours: 3 units; H(3-0)
Prerequisite(s): Consent of the instructor.

Medical Science 663

Advanced Muscle Mechanics and Physiology

A look at problems associated within muscle mechanics and contractility. Also the use of muscle mechanics as a scientific discipline to critically learn and evaluate the scientific process. Basic anatomy and physiology of muscle contraction including the cross-bridge theory, and the force-length, force-velocity and force-time relationships of actively and passively contracting muscles will also be covered.
Course Hours: 3 units; H(3-1/2)
Prerequisite(s): Consent of the Faculty.
Also known as: (Kinesiology 663) (Mechanical Engineering 663)

Medical Science 668

Biotechnology Commercialization

Technology commercialization is the process of translating research results, scientific discoveries or processes and methods into a commercially useful and profitable product. Students will study the biotechnology commercialization process and will develop a mock-up i) starting with a new product or service idea, ii) carrying out the early stage development, iii) developing the necessary strategic and business plans, iv) securing adequate and appropriate financing, and v) marketing and selling the product. The primary deliverable will be the creation of a strategic plan for an innovative biotechnology product or service.
Course Hours: 3 units; H(3-3)
Prerequisite(s): Must be registered in the Biomedical Technology Graduate Program. Consent of instructor(s) is required for all other students.

Medical Science 669

Clinical Trials and Bio-manufacturing

The objective of this course is to provide general understanding and appreciation, regulatory requirements and ethical considerations around conducting clinical trials as well as bio-pharmaceutical manufacturing. An emphasis will be placed on regulatory obligations. The course will provide opportunities in writing protocols, clinical trial applications, auditing facilities and process validation.
Course Hours: 3 units; H(3S-3T)
Prerequisite(s): Must be registered in the Biomedical Technology Graduate Program. Consent of instructor(s) is required for all other students.

Medical Science 670

Practicum in Biomedical Technology

A six unit (full) course carried out in an academic or industrial setting for a period of at least twelve weeks. Students have an opportunity to apply the principles and methods of investigation learned during the Master of Biomedical Technology program and carry out related research. Practicum projects can be focused on any of the following aspects of the commercialization process: patent filing, research and development, business development, manufacturing to clinical trials, marketing and sales.
Course Hours: 6 units; F(0-6)
Prerequisite(s): Must be registered in the Biomedical Technology Graduate Program.
Notes: Completion of all other course requirements in Master of Biomedical Technology program is normally required prior to registration for this course. Exceptions must be approved by the Graduate Director.
NOT INCLUDED IN GPA

Medical Science 671

Techniques in Medical Science

Introduction to the theory of operation of electronic devices commonly used in biophysical studies including principles of amplifiers and filters, micro- and patch electrode techniques and computer-laboratory interfacing.
Course Hours: 3 units; H(0-6)
Prerequisite(s): Consent of the Faculty.
MAY BE REPEATED FOR CREDIT

Medical Science 672

Biotechnology Business Aspects

Aspects involved in taking an original scientific idea or discovery all the way to a start-up company will be covered. Lecturers discuss commercialization, venture capital, business plan, patents and law, marketing.
Course Hours: 3 units; H(2-0)
Prerequisite(s): Must be registered in the Biomedical Technology Graduate Program. Consent of instructor(s) is required for all other students.

Medical Science 673

Careers in Biotechnology

A series of talks and workshops designed to provide students with practical knowledge of the biotechnology industry. In collaboration with the University of Calgary Career Services, the course covers personal and professional development planning, resume writing, networking, negotiation and interviewing skills and job search strategies specifically for the biotechnology field. This course runs during the fall and winter block weeks with additional retreat days throughout the year.
Course Hours: 3 units; H(3S-0)
Prerequisite(s): Must be registered in the Biomedical Technology Graduate Program. Consent of instructor(s) is required for all other students.
Notes: Admission to the Master of Biomedical Technology program is normally required for enrolment in this course.
NOT INCLUDED IN GPA

Medical Science 674

Integrated Systems Course

The principles of molecular and cell biology, pathology, physiology, pharmacology, microbiology and immunology as applied to new diagnostics, vaccines or therapeutics. Lectures in the two courses are in parallel and fully integrated. Both courses are required components of the MBT program. The goal of the course, with an emphasis on cellular and molecular mechanisms in health and disease, is to provide students with the skills to interface with individuals in these disciplines in the biotechnology industry. Complemented by special lectures that provide industry perspectives in these disciplines.

674.01. Physiological and Pharmacological Aspects of Therapeutics Development

674.02. Molecular Cell Biology of Diagnostic and Vaccine Development

Course Hours: 6 units; F(3-0)
Prerequisite(s): Must be registered in the Biomedical Technology Graduate Program. Consent of instructor(s) is required for all other students.

Medical Science 675

Bioinformatics Resources for the Biologist

This introductory graduate level course will familiarize biologists with algorithms and search engines used to analyze nucleic acid and protein sequences and structures.
Course Hours: 3 units; H(2-3T)
Prerequisite(s): Consent of the Faculty.

Medical Science 676

Scripting and Database Querying for Molecular Biologists

Intended for biologists who wish to improve their bioinformatics analysis capabilities by learning just a small amount of query and programming syntax. The focus is on practicality rather than programming theory. The course explores how to use existing tools (on the command-line and on the Web) to gather and process large datasets all at once, rather than doing many individual analyses manually.
Course Hours: 3 units; H(2.5-1)
Notes: No prior programming experience is required.

Medical Science 677

Directed Study in Biomedical Technology

Lectures, seminars, term papers or training in theoretical and/or laboratory methods at the advanced level in biomedical technology or medical sciences.
Course Hours: 3 units; H(1-6)
Prerequisite(s): Consent of both the faculty member who will supervise and the MBT faculty member who will co-supervise the chosen study and must be registered in the Master of Biomedical Technology program.
MAY BE REPEATED FOR CREDIT

Medical Science 678

Project in Biomedical Technology

Students will conduct both business and laboratory-based projects throughout the year. The business-based aspect will include running a business, doing market research for companies or working with their business mentor. The laboratory-based aspect will include new diagnostics development and validation. This course will cover basic principles of project management as well as biotech lab theory and practical aspects covered via tutorials, journal club and laboratory sessions. There will be a combination of monthly meetings, lectures, lab tutorials, commercial technology reviews, tours, demos, and practical labs.
Course Hours: 3 units; H(1-3T-6)
Prerequisite(s): Must be registered in the Biomedical Technology Graduate Program. Consent of instructor(s) is required for all other students.

Medical Science 679

Fundamentals of Bioinformatics

Foundational techniques and current research in bioinformatics are explored. Topics covered will include large-scale programmatic data access via data-marts and genome browsers, visualization, statistical techniques, and analysis of sequence and ‘omics datasets.
Course Hours: 3 units; H(2-2)
Prerequisite(s): Registration in the Bioinformatics specialization of the Biochemistry and Molecular Biology graduate program or consent of the instructor.
Notes: This course assumes some computational background including programming or scripting ability.

Medical Science 683

The Biology and Therapy of Human Cancer

An examination and discussion of current knowledge of the molecular and cellular biology of human cancer and the scientific basis of cancer therapy. Offered in a modular format: each course will consist of one required module and two elective modules. Students can choose the elective modules from a list that is specific for each course. Modules will emphasize student presentations, critical evaluation, and discussions of current and seminal research papers on the module topic. Refer to the Arnie Charbonneau Cancer Institute website at: http://charbonneau.ucalgary.ca/ for more information.

683.01. Cancer Pathology, Epidemiology and Therapy

683.02. Molecular Mechanisms of Cancer

683.04. Cell Biology of Cancer

Course Hours: 3 units; H(3-0)
Prerequisite(s): Must be a Cumming School of Medicine graduate student. All other students require consent of the instructor.

Medical Science 685

Biomechanics of Human Movement

Introduction to the measuring methods (accelerometry, goniometry, film and film analysis, video systems) of biomechanical analysis of human movement (force and force distribution). Description of the mechanical properties of bone, tendon, ligaments, cartilage, muscles, and soft tissues. The relation between structure and function of biomaterials. Introduction in descriptive analysis of human movement.
Course Hours: 3 units; H(3-3)
Prerequisite(s): Consent of the Faculty.
Antirequisite(s): Credit for more than one of Medical Science 685, Mechanical Engineering 685 and Kinesiology 685 is not allowed.
Also known as: (Mechanical Engineering 685)

Medical Science 689

Medical Imaging

Introduction to the theory and practical applications of medical imaging. Specific courses focus on an overview of modern diagnostic imaging techniques (689.01), as well as advanced study of specific techniques including magnetic resonance imaging (689.02) and medical image processing (689.03), and molecular imaging (689.04).

689.01. Medical Imaging Techniques

689.02. Advanced Magnetic Resonance Imaging

689.03. Advanced Medical Image Processing

689.04. Advanced Molecular Imaging

689.10. Medical Imaging Theory

689.11. Medical Imaging Applications

689.99. Medical Imaging Project

Course Hours: 3 units; H(3-0)
Prerequisite(s): Consent of the Faculty.
Notes: Medical Science 689.01 is the core course and should be taken prior to taking any of the advanced Medical Science 689 courses. Courses are open to students registered in the Medical Imaging specialization, other interested graduate students in the fields of medicine, engineering, and science and to appropriately prepared undergraduate students enrolled in computer engineering, electrical engineering, and physics.

Medical Science 701

Advanced Topics in Reproductive Health

A series of topics, ranging from basic sciences to clinical topics (including ethical issues) to increase awareness and comprehension regarding current issues in reproductive health.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Consent of course co-ordinator and student's supervisor, if applicable.
Notes: Interest in reproductive health/reproductive biology is essential.
Also known as: (Veterinary Medicine 701)

Medical Science 703

Human Anatomy: Concepts, Exploration and Teaching

Introductory course for graduate students with an interest in mammalian morphology to human cadaver dissection, human anatomy concepts and teaching strategies within the medical professional curriculum. Weekly lectures and discussions supplement a cadaver dissection-based course intended for students interested in pursuing an academic career in a medically related field.
Course Hours: 3 units; H(2-6)
Prerequisite(s): Should have some previous experience with dissection. Consent of the instructors.

Medical Science 706

Theory and Practice of Family Therapy

Overview of different family therapy approaches focusing on systemic assessment and systemic intervention through therapeutic interviewing. The development of student knowledge and skills in family therapy utilizing social constructionist, narrative, systemic, collaborative, and pro-feminist ideas while fostering the professional identity of the therapist.

706.01 Theory and Practice of Family Therapy I: Systemic Approaches

706.02 Theory and Practice of Family Therapy II: Postmodern Approaches

Course Hours: 3 units; H(3-0)
Prerequisite(s): Must be registered in the Cumming School of Medicine graduate programs. All others will require consent of the instructor.

Medical Science 707

Family Therapy Practicum

The development of conceptual and experiential expertise in working therapeutically with families.

707.01. Family Therapy I

707.02. Family Therapy II

Course Hours: 3 units; H(2S-12)
Prerequisite(s): Consent of the Faculty.
NOT INCLUDED IN GPA

Medical Science 708

Theory and Practice of Interprofessional Psychosocial Oncology

Provides graduate students with a multidisciplinary introduction to the field of psychosocial oncology. Emphasis will be placed on understanding and interpreting the experience of cancer informed by theory, evidence and illness narratives. Case-based learning in small interprofessional groups will allow students to explore a variety of key learning themes relevant to psychosocial oncology including distress assessment, depression, anxiety, adjustment and coping, sexuality, loss and grief. Attention to diversity will be integrated throughout the course.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Consent of the instructor.
Notes: Must have an undergraduate degree in a relevant domain (including, but not limited to medicine, psychology, nursing, social work, spiritual care/theology). This is an online course.

Medical Science 710

Business and Careers in Biotechnology

An overview of the biotechnology sector from several perspectives: product development, regulatory, intellectual property, market analysis and finance. This course will include series of lectures and discussions to provide both the necessary background about the biotechnology industry and an understanding of careers in the biotechnology industry.

Course Hours: 3 units; H(3-0)
Prerequisite(s): Must be a registered graduate student in a thesis-based Masters or Doctoral program.

Medical Science 713

Topics in Mountain Medicine and High Altitude Physiology

A tutorial-based course focused on high altitude medicine and physiology. The aim of the course is to introduce the students to the physiological adaptations of, and pathophysiology associated with, the hypoxia of altitude. Students will be introduced to several diseases associated with the hypoxia of high altitude (i.e., Acute Mountain Sickness; High Altitude Pulmonary Edema, High Altitude Cerebral Edema), and the pathophysiology underlying these diseases.
Course Hours: 3 units; H(0-3T)
Prerequisite(s): Consent of the instructor.

Medical Science 721

Biochemistry and Molecular Biology

Discussions and presentations in a small group format will highlight historical and recent developments in analysis of eukaryotic genomes and control of gene expression, chromosome structure, translation, protein structure, proteomics, regulatory networks and related technologies and their applications to the study of human diseases. Additional learning objectives relate to the critical assessment of published literature as well as the development of research proposal writing and presentation skills.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Must be registered in the Biochemistry and Molecular Biology Graduate Program. Consent of the instructor is required for all other students.

Medical Science 722

The Blood Vessel

Modular course offering advanced knowledge at the cellular, molecular, and whole organism levels including the hormonal regulation of the vascular system, the interaction between endothelium and smooth muscle in the blood vessel, the molecular mechanisms underlying smooth muscle contraction and relaxation, differentiation and dedifferentiation, and the pathogenesis of vascular diseases including hypertension and atherosclerosis. Drug treatments for vascular diseases and their molecular mechanisms will also be covered.

722.01. Vascular Biology
722.02. Vascular Pharmacology

Course Hours: 3 units; H(4-0)
Prerequisite(s): Open to graduate students registered in the Cumming School of Medicine graduate programs. All other students require consent of instructor.
Antirequisite(s): Credit for Medical Science 722.01 and 722.02 will not be allowed.

Medical Science 740

Smooth Muscle Structure Function

An inquiry-based approach used to provide students with a broad background for the study of smooth muscle and to introduce students to current trends in the field. Students will also be introduced to the spectrum of research on smooth muscle ongoing at the University of Calgary. The subjects to be included range from the molecular biology and biochemistry of individual proteins to the function and regulation of integrated smooth muscle systems. A number of methodological approaches that are being used for the study of smooth muscle will also be discussed.

Course Hours: 6 units; F(3T-0)
Prerequisite(s): Consent of the instructor.

Medical Science 744

Human Pathology

The principles of basic pathology, including cellular responses to injury, inflammation, tissue reaction, hemodynamic, basic genetics, and neoplasia are taught through a series of interactive lectures and seminars which are applied to examine the human system and the diseases that affect it.
Course Hours: 6 units; F(3-0)
Prerequisite(s): Must be registered in the Pathologists’ Assistant Master’s graduate program or the Pathologists’ Assistant specialization of the Medical Science graduate program. Consent of instructor is required for all other students.

Medical Science 745

Human Histology

Normal histology of the human body and how it relates to the pathologic mechanisms of function and disease will be discussed and presented in small group format.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Must be registered in the Pathologists’ Assistant Master’s graduate program or the Pathologists’ Assistant specialization of the Medical Science graduate program. Consent of instructor is required for all other students.

Medical Science 746

Integrated Pathologists’ Assistant Skills

A series of discussions and workshops to solidify the knowledge gained throughout the Pathologists’ Assistant Master’s program that will provide practical knowledge of the Pathologists’ Assistant profession, in particular focusing on laboratory management skills, quality control and quality assurance, and the legal and accreditation requirements for medical laboratories.
Course Hours: 3 units; H(3-0)
Prerequisite(s): Must be registered in the Pathologists’ Assistant Master’s graduate program. Consent of instructor is required for all other students.

Medical Science 747

Pediatric Pathology Practicum

Practical training in the technical skills of grossing a surgical specimen from the pediatric population in a safe and appropriate manner, as well as grossing placentas and performing fetal autopsies. Skill development will include quality management, ancillary techniques, and medical photography.
Course Hours: 3 units; H(0-3)
Prerequisite(s): Must be registered in the Pathologists’ Assistant Master’s graduate program or the Pathologists’ Assistant specialization of the Medical Science graduate program. Consent of instructor is required for all other students.

Medical Science 748

Surgical Pathology Practicum

The primary goal is the technical skills of grossing a surgical specimen in a safe and appropriate manner. Secondary goals include skill development in quality management, ancillary techniques, frozen section cutting, and medical photography.

748.01. Surgical Pathology Practicum I
748.02. Surgical Pathology Practicum II

Course Hours: 3 units; H(0-3)
Prerequisite(s): Must be registered in the Pathologists’ Assistant Master’s graduate program or the Pathologists’ Assistant specialization of the Medical Science graduate program. Consent of instructor is required for all other students.
Notes: Students are required to take both Medical Science 748.01 and Medical Science 748.02.

Medical Science 749

Autopsy Pathology Practicum

Hands on rotation that will train students how to perform autopsies under the supervision of a pathologist. Knowledge from anatomy, physiology, histology, and human pathology will be incorporated in the training.

749.01. Autopsy Pathology Practicum I
749.02. Autopsy Pathology Practicum II

Medical Science 750

Pathologists' Assistant Research Project

Guided work with practical research, encouraging independent thought and collaboration with pathologists and clinical colleagues. Requires completion of written reports and oral presentation on research performed.

750.01. Pathologists' Assistant Research Project I
750.02. Pathologists' Assistant Research Project II

Course Hours: 3 units; H(0-4)
Prerequisite(s): Must be registered in the Pathologists’ Assistant Master’s graduate program. Consent of instructor is required for all other students.
Notes: Students are required to take both Medical Science 750.01 and Medical Science 750.02. After consultation with a Departmental faculty member who will supervise the chosen project, approval must be obtained from the Program Director before a student can register.

Medical Science 751

Topics in Medical Science

751.07. The Physiological Development of the Fetus and Newborn

751.09. Ion Channel Diseases

751.31. Joint Injury and Disease Biomechanical Focus

751.43. Orientation and Clinical Rotations for Pathologists’ Assistants

Course Hours: 3 units; H(3-0)
Prerequisite(s): Consent of the Faculty.
Notes: Enrolment in Medical Science 751.43 is restricted to students registered in the Pathologists' Assistant Specialization in the Medical Science (Master's) graduate program.

Medical Science 755

Directed Study

Lectures, seminars, term papers or training in theoretical and/or laboratory methods at the advanced level in the medical sciences.
Course Hours: 3 units; H(1-6)
Prerequisite(s): Consent of the Faculty.
Notes: Submission of application is required to set up directed study topic. Forms available from the Graduate Science Education Office in the Cumming School of Medicine.
MAY BE REPEATED FOR CREDIT

UofC