McFarlane Lab

Dr. Sarah McFarlane

Publications (last 10 years)


Selected McFarlane Lab Publications (2011-2021):


1. Bertolesi, G.E., Debnath, N., Malik, H.R., Man, L.L.H. and McFarlane, S. (2022) Type II opsins in the eye, the pineal complex and the skin of Xenopus laevis. Using changes in skin pigmentation as a readout of visual and circadian activity. (in press, Frontiers in Neuroanatomy)

2. Bertolesi, G.E., Debnath, N., Atkinson-Leadbeater, K., Niedzwiecka, A. and McFarlane, S. (2021) Distinct type II opsins in the eye decode light properties for background adaptation and behavioural background preference. Molecular Ecology 30(24):6659-6676. doi: 10.1111/mec.

3. Watterston, C., Halabi, R., McFarlane, S. and Childs, S.J. (2021) Endothelial Semaphorin 3b regulates Vegf pathway-mediated angiogenic sprouting. PLoS Genetics 17(8):e1009769. doi: 10.1371/journal.pgen.1009769.

4. Cechmanek1, P.B., Hehr2, C.L. and McFarlane, S. (2021) Interactions between Retinal Pigment Epithelium and Neural Retinal Progenitors Mediated by Semaphorin 6D Facilitates Optic Cup Morphogenesis. eNeuro 8(3): ENEURO.0053-21.2021

5. Halabi, R.H., Watterston, C., Hehr, C.L. Mori-Kreiner, R., Childs, S.J. and McFarlane, S. (2021) Semaphorin 3f controls ocular vascularization from the embryo through to the adult. IOVS 62(2):21. doi: 10.1167/iovs.62.2.21

6. Bertolsi, G.E., Atkinson-Leadbeater, K. Mackey, E.M., Song, Y.-N., Heyne, B., and McFarlane, S. (2020) The regulation of skin pigmentation in response to environmental light by pineal Type II opsins and skin melanophore melatonin receptors. Photochemistry and Photobiology B doi: 10.1016/j.jphotobiol.2020.112024

7. Bertolesi, G.E. and McFarlane, S. (2020) Melanin concentrating hormone like and somatolactin. A teleost specific hypothalamic-hypophyseal axis system linking physiological and morphological skin pigmentation. Pig. Cell Mel. Research doi: 10.1111/pcmr.12924

8. Yang JJ, Bertolesi GE, Hehr CL, McFarlane S. (2020) Lhx2/9 and Etv1 Transcription Factors have Complementary roles in Regulating the Expression of Guidance Genes slit1 and sema3a. Neuroscience. 2020 May 10;434:66-82

9. Yang JJ, Bertolesi GE, Dueck S, Hehr CL, McFarlane S. (2019) The Expression of Key Guidance Genes at a Forebrain Axon Turning Point Is Maintained by Distinct Fgfr Isoforms but a Common Downstream Signal Transduction Mechanism. eNeuro. 2019 Apr 9;6(2). pii: ENEURO.0086-19.2019

10. Bertolesi GE, Zhang JZ, McFarlane S. (2019) Plasticity for colour adaptation in vertebrates explained by the evolution of the genes pomc, pmch and pmchl. Pigment Cell Melanoma Res. 2019 Jul;32(4):510-527

11. Hehr CL, Halabi R, McFarlane S. (2018) Polarity and morphogenesis of the eye epithelium requires the adhesion junction associated adaptor protein Traf4. Cell Adh Migr. 2018;12(5):489-502

12. Yang JJ, Bertolesi GE, Hehr CL, Johnston J, McFarlane S. (2018).Fibroblast growth factor receptor 1 signaling transcriptionally regulates the axon guidance cue slit1. Cell Mol Life Sci. 2018 Oct;75(19):3649-3661

13. Bertolesi GE, McFarlane S. (2018) Seeing the light to change colour: An evolutionary perspective on the role of melanopsin in neuroendocrine circuits regulating light-mediated skin pigmentation. Pigment Cell Melanoma Research 2018 May;31(3):354-373

14. Cechmanek, P.B., and McFarlane, S. (2017) Retinal pigment epithelium expansion around the neural retina occurs in two separate phases with distinct mechanisms. Devt Dynamics 246, 598-609

15. Bertolesi, G.E., Song, Y.-N., Atkinson-Leadbeater, K., Yang, J.-L., and McFarlane, S. (2017) Interaction and developmental activation of two neuroendocrine systems that regulate light-mediated skin pigmentation. Pigment Cell & Melanoma Research 30, 413-423

16. Bertolesi, G.E., Hehr, C.L., Mumm, H., McFarlane, S. (2016) Two light-activated neuroendocrine circuits arising in the eye trigger physiological and morphological pigmentation. Pigment Cell & Melanoma Research 29, 688-701.

17. Bertolesi, G.E., Vazhappily, S.T., Hehr, C.L., and McFarlane, S. (2016) Pharmacological induction of pigmentation unveils the neuroendocrine circuit regulated by light. Pigment Cell and Melanoma Research 29: 186-198.

18. Atkinson-Leadbeater, K., Hehr, C.L., Johnston, J., Bertolesi, G., McFarlane, S(2016) EGCG stabilizes growth cone filopodia and impairs retinal ganglion cell axon guidance. Devt Dynamics 245: 667-677.

19. Bertolesi, G.E., Hehr, C.L., McFarlane, S. (2015) Melanopsin photoreception in the eye regulates light-induced skin colour changes through the production of ?-MSH in the pituitary gland. Pigment Cell & Melanoma Research 28, 559-571.

20. Cechmanek, P.B., Hehr, C.L. and McFarlane, S. (2015) Rho Kinase is Required to Prevent Retinal Axons from Entering the Contralateral Optic Nerve. Mol. Cell. Neurosci. 69, 30-40.

21. Atkinson-Leadbeater, K., Hehr, C.L., Johnston, J. and McFarlane, S. (2014) FGFR signaling is required as the early eye field forms to promote later patterning and morphogenesis of the eye. Devt Dynamics 243, 663-675.

22. Bertolesi, G.E., Hehr, C.L. and McFarlane, S. (2014) Wiring the retinal circuits activated by light during early development. Neural Devt 9(1):3. doi: 10.1186/1749-8104-9-3.

23. Ebert, A.M., Childs, S.J., Hehr, C.L., Cechmanek, P.B. and McFarlane, S. (2014) Sema6a and Plxna2 mediate spatially regulated repulsion within the developing eye to promote eye vesicle cohesion. Development 141, 2473-2482.

24. Kita, E., Bertolesi, G.E., Hehr, C.L., Johnston, J. and McFarlane, S(2013) Neuropilin-1 biases dendrite polarization in the retina. Development 140, 2933-2941.

25. Rohs, P., Ebert, A.M., Zuba, A. and McFarlane, S. (2013) Neuronal expression of fibroblast growth factor receptors in zebrafish. Gene Expression Patterns, 13, 354-361.

26. Ebert, A.M., Lamont, R.E., Childs, S.J., and McFarlane, S. (2012) Neuronal expression of class 6 semaphorins in zebrafish. Gene Expression Patterns 12, 117-122.

27. Hocking, J.C., Pollock, N.S., Johnston, J., Wilson, R.J., Shankar, A., and McFarlane, S. (2012) Neural Activity and Branching of Embryonic Retinal Ganglion Cell Dendrites. Mechanisms of Development 129, 125-135.

28. McFarlane, S. and Lom, B. (2011) The Xenopus retinal ganglion cell as a model neuron to study the establishment of neuronal connectivity. Developmental Neurobiol. 2012 Apr;72(4):520-36. doi: 10.1002/dneu.20928.