SYNAPTIC REMODELLING
How we think and act is determined by how the neurons in our brain are connected together. When we learn and remember things, these connections are changed, a process called synaptic remodeling. Disorders in synaptic remodelling are hypothesized to contribute to cognitive dysfunction, such as observed in Autism Spectrum Disorder (ASD).
ACTIVITY-DEPENDENT POSTSYNAPTIC REMODELLING
We monitor the subcellular localization and mobility of postsynaptic molecules like actin, neuroligin, PSD-95 and Shank in live cells to determine how they behave in response to activity. Our aim is to discover fundamental regulatory interactions that may be important for activity dependent synaptic remodelling.
