|
|
|
Medical Graduate Education
601
|
Business Fundamentals
|
|
An overview of the primary business aspects involved in the health care product development industry, including company creation, intellectual property, financing, regulatory and clinical affairs, valuations and exit strategies. The principle objective is to develop a general understanding of how these different aspects integrate to form a functioning business.
Course Hours:
1 unit (12 hours)
Prerequisite(s):
Admission to the Master of Biomedical Technology program or consent of the Program Director.
|
back to top | |
|
Medical Graduate Education
602
|
Intellectual Property and Licensing
|
|
A hands-on look at intellectual property and licensing, including reviews of actual biotechnology patents, licenses, and term sheets. Following an overview discussion on intellectual property, a deeper dive into patent and license construction enables the students to craft their own simple patents and license term sheets.
Course Hours:
1 unit (12 hours)
Prerequisite(s):
Admission to the Master of Biomedical Technology program or consent of the program.
|
back to top | |
|
Medical Graduate Education
603
|
Project Management and Corporate Leadership
|
|
Knowledge Building of project management tools and techniques, including their implementation in project planning and delivery. Explanation of corporate, personal and team leadership as well as principles applicable to larger organizations will be discussed.
Course Hours:
1 unit (12 hours)
Prerequisite(s):
Admission to the Master of Biomedical Technology program or consent of the program.
|
back to top | |
|
Medical Graduate Education
604
|
Finances in Biomedical Technology
|
|
Explores how the financial community views and values biotechnology business opportunities, and the concepts and skills required to do the financial analysis. Covers some of the issues surrounding the investment process and expectations when interacting with potential investors, reading and analyzing financial statements, estimating and forecasting cash flows, and value investment and financing proposals.
Course Hours:
1 unit (12 hours)
Prerequisite(s):
Admission to the Master of Biomedical Technology program or consent of the program.
|
back to top | |
|
Medical Graduate Education
605
|
Regulatory Affairs
|
|
Examines key regulatory requirements of the leading regulatory bodies globally for biologic, small molecule, and medical device manufacturing, including consequences of non-compliance in regulatory affairs.
Course Hours:
1 unit (12 hours)
Prerequisite(s):
Admission to the Master of Biomedical Technology program or consent of the program.
|
back to top | |
|
Medical Graduate Education
606
|
Clinical Trials
|
|
Provides a general understanding and overview of clinical trials, their conduct and how they are regulated. An emphasis will be placed on regulatory obligations and current trends.
Course Hours:
1 unit (12 hours)
Prerequisite(s):
Admission to the Master of Biomedical Technology program or consent of the program.
|
back to top | |
|
Medical Graduate Education
607
|
Communication, Marketing and Sales
|
|
Introduces communication planning, marketing segmentation and sales strategies for the health product sector of biotechnology targeting the investment segment, health professionals and end-users.
Course Hours:
1 unit (12 hours)
Prerequisite(s):
Admission to the Master of Biomedical Technology program or consent of the program.
|
back to top | |
|
Medical Graduate Education
608
|
Business Case Studies
|
|
Examines strategic planning, business model and priorities of biotechnology companies. Critical evaluation of publicly traded biotechnology companies.
Course Hours:
1 unit (12 hours)
Prerequisite(s):
Admission to the Master of Biomedical Technology program or consent of the program.
|
back to top | |
|
Medical Graduate Education
609
|
Business Integration
|
|
Integrating lessons learned in prior business modules and extrapolating to the corporate environment, plus business pitches.
Course Hours:
1 unit (12 hours)
Prerequisite(s):
Admission to the Master of Biomedical Technology program or consent of the program.
|
back to top | |
|
Medical Graduate Education
610
|
Foundations of Bioinformatics
|
|
An exploration of the algorithmic foundations of established and emerging bioinformatics techniques, spanning dynamic programming, stochastic processes, probabilistic modelling, Bayesian inference, machine learning, and other topics from computational statistics. Big versus small data, divergent philosophical perspectives, and recent controversies in genomics are addressed through in-class discussions, current literature, and self-directed workshops.
Course Hours:
1 unit; (1-0)
Prerequisite(s):
Admission to the Bioinformatics specialization of the Biochemistry and Molecular Biology graduate program; or some computational background including programming or scripting ability and consent of the faculty.
Also known as:
(formerly Medical Science 679)
|
back to top | |
|
Medical Graduate Education
612
|
Foundations of Machine Learning
|
|
Basic statistical/computational theories and current libraries for machine learning will be introduced. Content may evolve according to the progress of the field but includes: 1. History and current status of machine learning. 2. Linear models and regularization. 3. Support vector machine and kernel methods. 4. Neural networks (including deep learning). The module introduces both theories and implementations, with a focus on applying the techniques to biological and medical big-data. The level of difficulties may be adjusted according to the diverse backgrounds of the attendees.
Course Hours:
1 unit; (1-0)
Prerequisite(s):
Medical Graduate Education 610 or consent of the instructor.
|
back to top | |
|
Medical Graduate Education
614
|
Biology for Bioinformatics
|
|
An introduction to how biologists approach the study of the problems of life, with an emphasis on sub-organismal scales (molecular and cell biology, biochemistry, and genetics), model organisms, and evolutionary processes.
Course Hours:
1 unit; (1-0)
Notes:
This course is intended for students in the Bioinformatics specialization of the Biochemistry and Molecular Biology graduate program who lack prior significant course work in the life sciences.
|
back to top | |
|
Medical Graduate Education
615
|
Communicating Science and Innovation
|
|
Covers basic principles of communicating complex science topics in a clear, vivid and engaging way to
distinct audiences including the general public. Includes exploration of the deep and fundamental
challenge facing scientists communicating their work and the importance of resetting the dial from
“content first” to “audience first”
Course Hours:
1 unit; (12 hours)
Prerequisite(s):
Admission to the Biomedical Technology Graduate Program or consent of the instructor(s).
|
back to top | |
|
Medical Graduate Education
620
|
The Essentials of Cancer Science
|
|
A comprehensive overview of the fundamentals of cancer, encompassing the hallmarks of cancer, cancer epidemiology and prevention, the basics of early cancer detection, historical-to-modern standards of cancer patient care and anti-cancer therapy, and the essentials of data science in the cancer paradigm.
Course Hours:
1 unit (12 hours)
Prerequisite(s):
Admission to the Biochemistry and Molecular Biology graduate program, admission to the Cancer Biology Specialization of the Medical Science graduate program, or consent of the faculty.
Also known as:
(formerly Medical Graduate Education 621)
|
back to top | |
|
Medical Graduate Education
622
|
Principles and Applications of Proteomics
|
|
An overview of proteomics, focussing on the objectives of these disciplines, the technologies, methods and informatics used in biological mass spectrometry as applied to the ‘omics. This involves the practical analysis of a protein sample provided to (or by) the student in a laboratory environment, and the generation of an informatics report.
Course Hours:
1 unit (12 hours)
Prerequisite(s):
Admission to the Biochemistry and Molecular Biology graduate program, admission to the Cancer Biology Specialization of the Medical Science graduate program, or consent of the instructor.
|
back to top | |
|
Medical Graduate Education
623
|
Tumour Immunology and Immunotherapy
|
|
Introductory topics in tumour immunobiology and immunotherapy will be covered. Fundamental and translational topics including, tumour immunogenicity, tumour immune surveillance and editing, immune escape, active immunotherapy, passive immunotherapy, virotherapy and viral vaccines, therapies targeting immunosuppressive mechanisms, and personalized immunotherapy.
Course Hours:
1 unit (12 hours)
Prerequisite(s):
Admission to the Biochemistry and Molecular Biology graduate program, admission to the Cancer Biology Specialization of the Medical Science graduate program, or consent of the instructor.
|
back to top | |
|
Medical Graduate Education
624
|
Cell Cycle Regulation in Cancer and Aging
|
|
The links between cancer and aging, the experimental definition of the cell cycle, major events in G0, G1, S, G2, M, drivers and regulators of the cell cycle including oncogenes and tumour suppressors, cyclins, CDKs, CDIs and links to the cell cycle through tumour suppressors will be covered. An overview of biological and replicative aging including recent developments regarding the role of epigenetic modifications in cancer and aging.
Course Hours:
1 unit (12 hours)
Prerequisite(s):
Admission to the Biochemistry and Molecular Biology graduate program, admission to the Cancer Biology Specialization of the Medical Science graduate program, or consent of the instructor.
|
back to top | |
|
Medical Graduate Education
625
|
Epigenetics and Chromatin Dynamics
|
|
Fundamentals of eukaryotic chromatin assembly, dynamic chromatin regulation and post-translational modifications that comprise epigenetics. DNA methylation, histone post-translational modifications, histone variants, regulatory siRNA, nucleosome remodelling and higher-order chromatin organization. Cancer and disease-associated epigenetic alterations will be discussed in detail.
Course Hours:
1 unit (12 hours)
Prerequisite(s):
Admission to the Biochemistry and Molecular Biology graduate program, admission to the Cancer Biology Specialization of the Medical Science graduate program, or consent of the instructor.
|
back to top | |
|
Medical Graduate Education
626
|
DNA Damage Signalling and Repair
|
|
DNA repair pathways, highlighting the cellular responses to ionizing radiation will be covered, including: base excision repair, mismatch repair, nucleotide excision repair, and DNA single strand and double strand break repair. The relationship of replication stress and telomere maintenance to genomic instability in a cancer context will be covered.
Course Hours:
1 unit (12 hours)
Prerequisite(s):
Admission to the Biochemistry and Molecular Biology graduate program, admission to the Cancer Biology Specialization of the Medical Science graduate program, or consent of the instructor.
|
back to top | |
|
Medical Graduate Education
628
|
Tumour Microenvironment Dynamics
|
|
An overview of how tissue microenvironments influence tumour formation, evolution, progression and metastasis, and how to study this in the laboratory. May include tumour-stroma interplay, epithelial-mesenchymal transitions, angiogenesis, tumour metastasis and the effects of the tumour microenvironment on cancer therapy and diagnosis.
Course Hours:
1 unit (12 hours)
Prerequisite(s):
Admission to the Biochemistry and Molecular Biology graduate program, admission to the Cancer Biology Specialization of the Medical Science graduate program, or consent of the instructor.
|
back to top | |
|
Medical Graduate Education
629
|
Molecular Cancer Signalling Networks
|
|
A systematic review of the molecular events underlying cancer formation and evolution, including cancer-driving changes to inter- and intra-cellular growth signalling networks, key growth receptor molecular mechanisms and cancer-specific alterations to cell nutrient response pathways.
Course Hours:
1 unit (12 hours)
Prerequisite(s):
Admission to the Biochemistry and Molecular Biology graduate program, admission to the Cancer Biology Specialization of the Medical Science graduate program, or consent of the instructor.
|
back to top | |
|
Medical Graduate Education
630
|
Anti-Cancer Therapeutics and Clinical Trials
|
|
An overview of current anti-cancer therapeutics, including radiation, immuno- and chemo-therapeutic options, as well as the use of personalized medicine approaches to improving patient outcomes. Learning objectives include how to design preclinical studies to support human clinical trials, with a major focus on ethics considerations.
Course Hours:
1 unit (12 hours)
Prerequisite(s):
Admission to the Biochemistry and Molecular Biology graduate program, admission to the Cancer Biology Specialization of the Medical Science graduate program, or consent of the instructor.
|
back to top | |
|
Medical Graduate Education
631
|
Fundamentals of Brain Development, Physiology and Disease
|
|
A systemic overview of how the brain develops and functions at the cellular, biochemical and molecular level, but in the context of the etiology of prevalent and rare diseases, including neurodevelopmental and neurodegenerative syndromes, as well as paediatric and adult brain tumours.
Course Hours:
1 unit (12 hours)
Prerequisite(s):
Admission to the Biochemistry and Molecular Biology graduate program, admission to the Cancer Biology Specialization of the Medical Science graduate program, or consent of the instructor.
Antirequisite(s):
Credit for Medical Graduate Education 631 and Medical Science 619.01 will not be allowed.
|
back to top | |
|
Medical Graduate Education
632
|
Principles of Light Microscopy
|
|
Fundamentals of standard wide-field fluorescence microscopy as well as confocal and multiphoton techniques. Key concepts such as the optical light path, spatial resolution, and sampling will be emphasized. In addition, students will have the opportunity to assemble basic bright-field and fluorescence microscopes using optical “lego”.
Course Hours:
1 unit (12 hours)
Prerequisite(s):
Consent of the program.
|
back to top | |
|
Medical Graduate Education
633
|
Advanced Techniques in Optical Microscopy
|
|
Advanced techniques in optical microscopy covered though a combination of lectures and activities. Topics include total internal reflection (TIRF) microscopy, superresolution, light sheet techniques and other rapidly developing technologies. Also includes one or more selected topics in targeted illumination including fluorescence recovery after photo activation (FRAP).
Course Hours:
1 unit (12 hours)
Prerequisite(s):
Medical Graduate Education 632 or consent of the program.
|
back to top | |
|
Medical Graduate Education
634
|
Digital Imaging for Optical Microscopy
|
|
The concept of the digital image and its relevance to optical microscopy will be introduced. The workflow from image acquisition to image analysis and presentation of data for publication will be covered. Good practices and pitfalls will be emphasized at every step. Students will gain experience in image processing and analysis using the standard open source package FIJI.
Course Hours:
1 unit (12 hours)
Prerequisite(s):
Medical Graduate Education 632 or consent of the program.
|
back to top | |
|
Medical Graduate Education
635
|
Hereditary and Environmental Causes of Cancer
|
|
A summary of major sources and drivers of cancer, including the interplay between hereditary cancer predisposition and genetics, the relationship between metabolism and environmental carcinogens, viral and microbial sources of cancer, major chemical and radiation carcinogens, and modifiers of cancer risk, including behaviours, policies and interventions.
Course Hours:
1 unit (12 hours)
Prerequisite(s):
Admission to the Biochemistry and Molecular Biology graduate program, admission to the Cancer Biology Specialization of the Medical Science graduate program, or consent of the instructor.
Also known as:
(formerly Medical Graduate Education 627)
|
back to top | |
|
Medical Graduate Education
651
|
Microbial Virulence Factors
|
|
Virulence factors used by microbial pathogens to cause disease. Topics include microbial adherence mechanisms, toxigenic infections, virulence factor secretion systems, microbial gene expression.
Course Hours:
1 unit (12 hours)
Prerequisite(s):
Medical Science 611, Cellular, Molecular and Microbial Biology 431, or consent of the program.
|
back to top | |
|
Medical Graduate Education
652
|
Microbial Interactions at Epithelial Surfaces
|
|
Strategies used by microbial pathogens to target mucosal surfaces, and their contribution to disease. Topics include microbial disruption of epithelial barrier function, interactions with the host microbiome, microbial adaptation to host defenses, and invasion and intracellular survival strategies.
Course Hours:
1 unit (12 hours)
Prerequisite(s):
Medical Science 611, Cellular, Molecular and Microbial Biology 431, or consent of the program.
|
back to top | |
|
|
Medical Graduate Education
654
|
Infection and Immunity
|
|
Interactions with microbial pathogens with the innate and adaptive immune systems. Topics include immune evasion, pathogen clearance, and vaccine development.
Course Hours:
1 unit (12 hours)
Prerequisite(s):
Consent of the program.
|
back to top | |
|
Medical Graduate Education
655
|
Autoimmunity and Immunodeficiency
|
|
Advanced course focusing on the cellular and molecular mechanisms of systemic and organ-specific autoimmunity, acquired immunodeficiencies including those in the context of organ transplantation, and immunomodulatory therapies.
Course Hours:
1 unit (12 hours)
Prerequisite(s):
Consent of the program.
|
back to top | |
|
Medical Graduate Education
721
|
Biochemistry and Molecular Biology: Scientific Method, Data Analysis and Communication
|
|
Covers landmark discoveries in biochemistry and molecular biology (BMB), new and evolving BMB technologies, and how these can be implemented into modern research programs. Application of the scientific method, technical and ethical considerations surrounding data analysis, and essential skills for communicating scientific discoveries in the realm of peer-reviewed publication, presentation and grant application contexts.
Course Hours:
1 unit (12 hours)
Prerequisite(s):
Admission to the Biochemistry and Molecular Biology graduate program or consent of the instructor.
|
back to top | |
|
Medical Graduate Education
722
|
Nucleic Acids, DNA Replication, Transcription and RNA Signalling
|
|
Covers nucleic acid synthesis, utilization and degradation in cells. Understanding of structure-function relationships for nucleic acids, the enzymatic basis of DNA replication, how genes are read, how the transcribed RNA is processed, and how genes are regulated through a coordinated collaboration between proteins and nucleic acid sequences. Reviews emerging technologies in the study of nucleic acids and RNA at a molecular level.
Course Hours:
1 unit (12 hours)
Prerequisite(s):
Admission to the Biochemistry and Molecular Biology graduate program or consent of the instructor.
|
back to top | |
|
Medical Graduate Education
723
|
Translation, Protein Folding and Post-Translational Modification
|
|
Covers cellular proteins synthesis, modification and degradation. Topics include structure-function relationships for amino acids, the enzymatic basis of protein translation, how ribosomes are synthesized and regulated, how proteins are folded and may be modified post-translationally by enzymatic and non-enzymatic means. Emerging technologies in the study of proteins and post-translational modifications at a molecular level are reviewed.
Course Hours:
1 unit (12 hours)
Prerequisite(s):
Admission to the Biochemistry and Molecular Biology graduate program or consent of the instructor.
|
back to top | |
|
Medical Graduate Education
724
|
Introduction to Bioinformatics Resources
|
|
Covers key bioinformatics concepts and practices, as well as the basic knowledge of how to access resources for graduate-level biologists who are not bioinformatics specialists. Introduces essential bioinformatics terminologies, discusses the use of bioinformatics to infer information about an organism from its genome. Provides practical experience with bioinformatics tools and develop basic skills in the collection and presentation of bioinformatics data.
Course Hours:
1 unit (12 hours)
Prerequisite(s):
Admission to the Biochemistry and Molecular Biology graduate program or consent of the instructor.
|
back to top | |
|
Medical Graduate Education
725
|
Applied Genomics
|
|
Covers high throughput DNA sequencing technologies and genome-wide association genetics. Provides an overview of the available genomics technologies and their applications for high throughput discovery in biology (model organisms) and medicine (cancer and Mendelian disease genomics). Discussions will also encompass research ethics considerations for collecting, storing and using human genomic data.
Course Hours:
1 unit (12 hours)
Prerequisite(s):
Admission to the Biochemistry and Molecular Biology graduate program or consent of the instructor.
|
back to top | |
|
Medical Graduate Education
726
|
Applied Structural Biology
|
|
Students will learn how to describe structures of biological macromolecules and explain the most commonly occurring methods for determination and analysis of the three-dimensional structure of biomolecules. Provides an overview of biophysical and structural methods used to study the regulation and function of biomolecules, tutorials on commonly available structural visualization software and resources and how structure-guided drug design is being used for pre-clinical drug discovery.
Course Hours:
1 unit (12 hours)
Prerequisite(s):
Admission to the Biochemistry and Molecular Biology graduate program or consent of the instructor.
|
back to top | |
|
Medical Graduate Education
755
|
Directed Studies
|
|
Lectures, seminars, term papers or training in theoretical and/or laboratory methods at the advanced level in the medical sciences.
Course Hours:
1 unit (12 hours)
Prerequisite(s):
Consent of the program.
MAY BE REPEATED FOR CREDIT
|
back to top | |
|
Medical Graduate Education
799
|
Topics in Medical Sciences
|
|
Course Hours:
1 unit (12 hours)
Prerequisite(s):
Consent of the program.
MAY BE REPEATED FOR CREDIT
|
back to top | |
|