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 University of Calgary Calendar 2010-2011 COURSES OF INSTRUCTION Course Descriptions C Cellular, Molecular and Microbial Biology CMMB
Cellular, Molecular and Microbial Biology CMMB

Instruction offered by members of the Department of Biological Sciences in the Faculty of Science.

Department Head - R.M.R. Barclay

†Note: Limited amounts of non-scheduled class time involvement will be required for this course.
 
Senior Courses
 
†Cellular, Molecular and Microbial Biology 343       Microbiology
An introductory study of prokaryotes, viruses and immunology with emphasis on systematics, ecology, physiology, molecular biology and roles in pathogenesis of the major groups of prokaryotes.
Course Hours: H(3-3)
Prerequisite(s): Biology 231 and one of Chemistry 341 or 351.
Corequisite(s): Prerequisites or Corequisites: One of Biochemistry 341 or 393 and Chemistry 353 or 355 (if 351 is completed as a prerequisite).
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Cellular, Molecular and Microbial Biology 403       Developmental Biology of Animals
Study of the mechanism of cellular differentiation with emphasis on intra- and intercellular processes.
Course Hours: H(3-1T)
Prerequisite(s): Biochemistry 393, Biology 311 and 331.
Notes: Enrolment in this course may be limited. See Enrolment Limitations in Courses in the Faculty of Science section of the Calendar.
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Cellular, Molecular and Microbial Biology 411       Molecular Genetics
Molecular biology and gene expression in prokaryotes and eukaryotes. Topics include: DNA topology, genome structure, chromatin structure, DNA replication, DNA repair and recombination, mechanisms of transcription and gene expression, post-transcriptional RNA processing, translation.
Course Hours: H(3-0)
Prerequisite(s): Biology 311 and 331.
Corequisite(s): Prerequisite or Corequisite: Biochemistry 401 or 443.
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Cellular, Molecular and Microbial Biology 413       Human Genetics
The principles of genetics as applied to human and medical genetics. Mendelian and multifactorial inheritance of normal and abnormal traits, pedigree analysis, segregation, linkage and gene mapping. Cytogenetics and developmental genetics. Population genetics including inbreeding and evolution in humans. Genetic predisposition to disease.
Course Hours: H(3-1T)
Prerequisite(s): Biology 311.
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Cellular, Molecular and Microbial Biology 421       Virology
Comprehensive overview of virus structure and replication; molecular events involved in virus infection and replication including genetics, biochemistry and molecular biology of bacterial, plant and animal viruses. Areas of persistent viruses, viral immunology, cancer and AIDS will be covered.
Course Hours: H(3-3)
Prerequisite(s): Biochemistry 393, Biology 311, 331, Cellular, Molecular and Microbial Biology 343.
Corequisite(s): Prerequisite or Corequisite: Biochemistry 401 or 443.
Notes: Enrolment in this course may be limited. See Program Details in the Faculty of Science section of this Calendar.  
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Cellular, Molecular and Microbial Biology 431       Bacterial Pathogens
An introduction to microbes that cause infections (in humans, other animals and plants.) Topics include: the relationship between pathogen and host, ability of pathogens to colonize, reproduce and cause disease, the role of antibiotics and vaccines in treatment and prevention of infection, antibiotic resistance in bacteria, environmental control of virulence factor production.
Course Hours: H(3-0)
Prerequisite(s): Cellular, Molecular and Microbial Biology 343.
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Cellular, Molecular and Microbial Biology 443       Microbial Physiology
The focus is structure and function of prokaryotic cells. Topics include cell envelope structure, cell division, transport and secretion, signal transduction, differentiation and development, bacterial growth and energetics, and the diversity of metabolic pathways in Bacteria and Archaea. The laboratory introduces analytical techniques commonly used in bacterial physiology, and some useful biochemical assays.
Course Hours: H(3-3)
Prerequisite(s): Biochemistry 393 and Cellular, Molecular and Microbial Biology 343.
Notes: Enrolment in this course may be limited. See Program Details in the Faculty of Science section of this Calendar.  
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Cellular, Molecular and Microbial Biology 451       Molecular Analysis of Biological Systems
A laboratory course emphasizing techniques in molecular biology that can be applied to the analysis of problems in cellular, molecular and microbial biology.
Course Hours: H(3-5)
Prerequisite(s): Cellular, Molecular and Microbial Biology 411.
Antirequisite(s): Credit for both Cellular, Molecular and Microbial Biology 451 and either Biochemistry 401 or 541 will not be allowed.
Notes: Only open to Majors in Cellular, Molecular and Microbial Biology or to Majors in the Biological Sciences Honours program.
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Cellular, Molecular and Microbial Biology 505       Advanced Developmental Biology
In-depth analyses of the current literature in developmental biology. Emphasis will be on the coordinated regulation of gene expression during development.
Course Hours: H(3S-0)
Prerequisite(s): Biochemistry 401 or 443, Cellular, Molecular and Microbial Biology 403.
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Cellular, Molecular and Microbial Biology 507       Special Problems in Cellular, Molecular and Microbial Biology
Lectures, seminars, term papers and training in theoretical and/or laboratory methods.
Course Hours: H(3-3)
Prerequisite(s): Completion of at least 9 full-course equivalents and consent of the Department.
MAY BE REPEATED FOR CREDIT
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Cellular, Molecular and Microbial Biology 511       Molecular Biology and Genetics
The concepts of molecular biology as they apply to genetics. Application of current methodology to the understanding of the genetics of prokaryotes, lower and higher eukaryotes (for example: fungi, yeasts, trypanosomes, plants and animals). Genomic organization and function of subcellular organelles such as mitochondria and chloroplasts will also be considered in detail. The mechanism(s) of regulation of gene expression will be discussed in relation to nuclear as well as organelle genomes.
Course Hours: H(3-0)
Prerequisite(s): Cellular, Molecular and Microbial Biology 411.
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Cellular, Molecular and Microbial Biology 519       Advanced Cell Biology
In-depth analysis of current literature in cell biology. Topics include the cytoskeleton, subcellular organization and dynamics, RNA and protein trafficking, and other aspects of eukaryotic cell biology.
Course Hours: H(3-0)
Prerequisite(s): Biology 311, 331 and one of Biochemistry 401 or 443.
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Cellular, Molecular and Microbial Biology 523       DNA, Genomes and RNA Function
An examination and comparison of the roles of DNA and RNA in the cell. Includes chromatin structure, transcriptional regulation, mechanisms of post-transcriptional regulation at the RNA level, and the diverse roles played by RNA, ranging from information molecules to structural scaffolds to ribozymes.
Course Hours: H(3-0)
Prerequisite(s): Cellular, Molecular and Microbial Biology 411.
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Cellular, Molecular and Microbial Biology 527       Immunology
Comprehensive overview of the immune responses: antibody-antigen interaction, antibody structure, genetics and synthesis, cellular immunology, MHC, phagocytosis, tolerance, autoimmunity, hypersensitivity, tissue rejection, tumour immunology and vaccine production. Responses to viral, bacterial, fungal and parasite infections. Methods for the study of immunology.
Course Hours: H(3-3)
Prerequisite(s): Biochemistry 401 or 443, Biology 311, 331, Cellular, Molecular and Microbial Biology 343.
Antirequisite(s): Credit for both Cellular, Molecular and Microbial Biology 527 and 427 will not be allowed.
Notes: Enrolment in this course may be limited. See Program Details in the Faculty of Science section of this Calendar.     
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Cellular, Molecular and Microbial Biology 528       Independent Studies in Cellular, Molecular and Microbial Biology
Original and independent thought, practical research and the completion of written and oral reports.
Course Hours: F(0-6)
Prerequisite(s): Completion of at least 15 full-course equivalents and consent of the Department.
MAY BE REPEATED FOR CREDIT
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Cellular, Molecular and Microbial Biology 530       Honours Research Project in Cellular, Molecular and Microbial Biology
Research project under the direction of one or more faculty members in the Department of Biological Sciences. Formal written and oral reports must be presented on completion of this course. Open only to Honours Cellular, Molecular and Microbial Biology students or Honours Biological Sciences students.
Course Hours: F(0-8)
Prerequisite(s): Cellular, Molecular and Microbial Biology 451, completion of at least 15 full-course equivalents and consent of the Department.
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Cellular, Molecular and Microbial Biology 531       Topics in Cellular Interactions
An exploration of selected topics concerning cell-cell interactions and the interactions of cells with their environment during development, differentiation and disease. Multidisciplinary approaches will be presented, using discussions of seminal research and critical analysis of current literature. Potential topics include cell junctions, cell signaling, cytoskeletal organization, stroma, extracellular matrix remodeling and stem cells.
Course Hours: H(3-0)
Prerequisite(s): Biology 331, and one of Biochemistry 443 or 431 or 401.
Antirequisite(s): Credit for both Cellular, Molecular and Microbial Biology 531 and 507.90 will not be allowed.
Notes: Prior completion of Cellular, Molecular and Microbial Biology 403 is highly recommended and Cellular, Molecular and Microbial Biology 451 or 527 are advantageous.
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Cellular, Molecular and Microbial Biology 543       Environmental Microbiology
Focuses on understanding the interactions of micro-organisms with their environment. Roles of micro-organisms in nutrient cycling, biological control, and biodegradation will be discussed. The use of molecular approaches to identify and characterize microbial communities, and to understand the precise nature of microbial interactions with abiotic and biotic environments will be emphasized. Special topics will include plant-microbe and animal-microbe symbiosis, extreme environments and biotechnological applications of environmental microbiology.
Course Hours: H(3-0)
Prerequisite(s): Cellular, Molecular and Microbial Biology 343 or consent of the Department.
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Cellular, Molecular and Microbial Biology 545       Petroleum Microbiology
Microorganisms can contribute to a more sustainable energy future. Their impact and roles in the fossil fuel industry will be reviewed. Topics will include oilfield souring, biocorrosion, biodegradation, enhanced recovery, upgrading, and bioremediation of contaminated sites.
Course Hours: H(3-0)
Prerequisite(s): Cellular, Molecular and Microbial Biology 343 or consent of the Department.
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Cellular, Molecular and Microbial Biology 549       Microbial Genetics
The structure and function of microbial genes and genomes will be analyzed with state-of-the-art bioinformatics programs. Advances in understanding of mechanisms of genetic exchange in bacteria and bacteriophages, including conjugation, transduction, transformation and lysogeny will be presented together with selected topics in microbial genetics.
Course Hours: H(3-0)
Prerequisite(s): Cellular, Molecular and Microbial Biology 411.
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Cellular, Molecular and Microbial Biology 561       Cancer Biology
Advances in methodology and in theoretical concepts have permitted continuing breakthroughs in our understanding of the organismal, cellular and molecular biology of cancer cells, and in the development of novel strategies for cancer prevention, diagnosis and treatment. These advances will be presented in a comprehensive overview of cancer including issues of demographics and incidence, causation and detection, origins and progression and therapeutic approaches. Emphasis will be placed on the cell and molecular biology of cancer and on the interaction of the cancer cell with the host organism.
Course Hours: H(3-0)
Prerequisite(s): Biology 331, Cellular, Molecular and Microbial Biology 411 and one of Biochemistry 401 or 443.
Also known as: (Medical Science 561)
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Graduate Courses

Enrolment in any graduate course requires consent of the Department.

Only where appropriate to a student's program may graduate credit be received for courses numbered 500-599.

600-level courses are available with permission to undergraduate students in the final year of their programs.

 
Cellular, Molecular and Microbial Biology 637       Advanced Topics in Molecular Microbiology
Techniques and discussion of recent literature in molecular microbiology. Topics covered will vary from year to year, but could include bioinformatics, genomics, mutagenesis, advanced microscopy techniques, proteomics, vectors and cloning techniques, gene expression, and over-expression of proteins, as they relate to the study of prokaryotic systems. Course content will be tailored to the interests of the graduate students enrolled in the class in a given year.
Course Hours: H(3-3)
MAY BE REPEATED FOR CREDIT
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