Braedon McDonald

1.  Microbiology and immunology of infections and sepsis in the ICU.

                a.     Gut microbiota dysbiosis in the pathogenesis of nosocomial infections and organ dysfunction in the ICU.

                b.     Multi-dimensional profiling of microbiota-immune interactions in ICU patients.

                c.     Host-microbe interactions and immune dysfunction in critical illness.

2.  Microbiota-immune interactions in the regulation of host defense against infections and sepsis.

                a.     Intravital imaging of host-microbe interactions in vivo.

                b.     Germ-free and gnotobiotic models of ICU dysbiosis.

                c.    Cellular and molecular mechanisms of microbiota-immune interactions during sepsis and critical illness.

3.  Translational research into precision therapeutics for the prevention and treatment of infections and sepsis in the ICU.

                a.     Development of precision microbiota-editing strategies to modulate microbiota-immune mutualism.

                b.   Immunotherapy for the treatment of infections and sepsis.

*****Accepting applications for Postdoctoral Fellows and Graduate Students*****