University of Calgary

Jeffrey Joseph, M.D., Ph.D.

Contact Information:

 Department of Pathology, C1146, Foothills Medical Centre
1403 - 29th Street NW, Calgary, Alberta Canada T2N 2T9
Phone: 403-944-8849
Fax: 403-944-1460
Email: Jeff [dot] Joseph [at] calgaryhealthregion [dot] ca

Dr. Jeffrey Joseph is a Professor in the Departments of Pathology and Laboratory Medicine, and Clinical Neurosciences at the University of Calgary.

Dr. Joseph graduated summa cum laude in Mathematics from the University of New Hampshire in 1977. After college, while in Peace Corps, he taught mathematics and science to high school students in the Kingdom of Tonga in the South Pacific. He subsequently attended Harvard Medical School, where he studied Medicine and completed graduate studies in Parasitology, receiving his M.D. and Ph.D. degrees in 1991. From 1991 to 1995 he completed residencies in Pathology and Neuropathology at several Boston-area institutions, including the Brigham and Women's Hospital, Children's Hospital, and the V.A. Medical Center in West Roxbury. This training included research experience at the Molecular Neurooncology Laboratory of the Massachusetts General Hospital in 1994. Dr. Joseph began clinical practice in neuropathology at the Beth Israel Deaconess Medical Center in Boston, MA, and was the principal neuropathologist there for 11 years. He was also an Instructor in, and then Assistant Director of, the preclinical neuroscience course at Harvard Medical School. In 2002, he was appointed to the position of Academy Scholar at Harvard Medical School. Dr. Joseph moved to the University of Calgary in the fall of 2007, where he is the Head of Neuropathology in the Department of Pathology and Laboratory Medicine.

Dr. Joseph's research interests span many areas of neuropathology, including childhood and adult neurodegenerative disorders, multiple sclerosis, and the pathological analysis of brain tumors. He has a long-standing interest in improving clinical education in neuropathology and is the author of several texts. He is currently working on a book about neuroradiology and neuropathology and also teaches extensively in the clinical and preclinical training programs at the University of Calgary.

Selected Publications:

Amick A, Joseph JT, Selim M. Amyloid beta related angiitis: a rare cause of recurrent transient ischemic attacks of unclear etiology. Accepted. Nat Clin Pract Neurol. 2008.

Parvizi J, Joseph JT, Press D, Schmahmann JD. Pathological laughter and crying in patients with multiple system atrophy -cerebellar type. Mov Disord. 2007; 22(6):798-803.

Jeffrey T. Joseph, MD, PhD. Diagnostic Smears in Neuropathology.  Philadelphia, PA: Lippincott, Williams &Wilkins; 2006.

Wuthrich C, Kesari S, Kim WK, Williams K, Gelman R, Elmeric D, De Girolami U, Joseph JT, Hedley-Whyte T, Koralnik IJ. Characterization of lymphocytic infiltrates in progressive multifocal leukoencephalopathy: co-localization of CD8(+) T cells with JCV-infected glial cells. J Neurovirol. 2006; 12(2):116-128.

Jeffrey T. Joseph, MD, PhD, David L. Cardozo, PhD. Functional Neuroanatomy: An Interactive Text and Manual.  Hoboken, New Jersey: John Wiley & Sons; 2004.

Petrogiannis-Haliotis T, Sakoulas G, Kirby J, Koralnik IJ, Dvorak AM, Monahan-Earley R, DE Girolami PC, DE GirolamiU, Upton M, Major EO, Pfister LA, Joseph JT. BK-related polyomavirus vasculopathy in a renal-transplant recipient. N Engl J Med. 2001; 345(17):1250-5.

Caruso P, Patel M, Joseph JT, Rachlin J. Primary intramedullary lymphoma of the spinal cord mimicking cervicalspondylotic myelopathy. Am J Neuroradiology. 1998; 171:526-527.

Joseph JT. Astrocytoma and Ki-67. J Neurosurg. 1997;87(1):133-4.

Joseph JT, Lisle DK, Jacoby LB, Paulus W, Barone R, Cohen ML, Roggendorf WH, Bruner JM, Gusella JF, Louis DN. NF2 gene analysis distinguishes hemangiopericytoma from meningioma. Am J Pathol. 1995; 147(5):1450-5.

Renshaw AA, Paulus W, Joseph JT. CD34 and epithelial membrane antigen distinguish dural hemangiopericytoma and meningioma. J. Applied Histochemistry. 1995; 36:108-114.