Research trainee investigating serious cardiac mutation

For World Heart Rhythm Week, we sat down with Shanshan Tian, a PhD candidate in the lab of UCalgary’s Dr. Wayne Chen to learn about her research. 

Tell us about your research

My PhD project focuses on mutations of the RyR2, a ryanodine receptor found in the heart that mediates calcium release to drive the heartbeat. Specifically, I am looking at truncation of the C terminal of the receptor—this means that a portion of the receptor is missing. So far, my work has shown that a specific pacing protocol can be used to diagnose patients with this mutation. 

Why is this important?

While some patients with this mutation seem fine, it can develop into a serious arrhythmia that might lead to sudden cardiac death. There are no treatments for this condition, and patients may not have any warning signs. Since this loss-of-function mutation can be genetic, diagnosing it in families may save lives. 

Tell us about your lab

Dr. Chen’s lab focuses mainly on arrhythmias. In 2021, the lab discovered a new disease related to RyR2 called Calcium Release Deficiency Syndrome (CRDS). Since then, we have also developed a diagnostic tool based on a specific cardiac pacing protocol and developed a treatment for the condition. My work, which mostly involves cellular studies, is a continuation of this work. 

What’s your goal with this research? 

My overall goal is to transfer my findings from the lab to the clinic. I don’t just want to focus on basic science; I am interested in helping patients and saving lives. It’s exciting to do this work for that reason. 

Tell us about your career path

I was born and raised in China and received my masters in pharmacology from Harbin Medical University. My supervisor previously worked in Dr. Chen’s lab. This connection brought me to Calgary to pursue my PhD. In this lab, I have learned many different scientific techniques and gained new experiences. 

What’s next for you? 

Once I have completed my PhD, I will look for other opportunities in this field. I may get a job or find a postdoctoral position. I may return to China, but if another international opportunity is available, it might be an opportunity to learn and have even more experiences.