Kris Chadee
Professor
Canada Research Chair (Tier 1) in Gastrointestinal Inflammation
PhD
MSc
BSc (Hons)
Contact information
Location
Research
Activities
A major effort underway in our laboratory is to understand the mechanisms whereby infectious agents, lipid mediators of inflammation and cytokines modulate innate, immune and mucosal epithelial cell functions. Of particular interest to our group is the emerging concept that cross-talk between pathogen components and host cells or both, can predetermine the outcome of inflammatory or host defence mechanisms. Consistent with this concept, our program of research is divided into three areas as follows:
1. To define the biochemical and molecular interactions by which the mucosal pathogen, E. histolytica trophozoites or its components can modulate luminal (mucus/bacteria) and epithelial barrier function in the gut.
2. To determine the molecular mechanisms by which PGE2 regulates pro-inflammatory responses in human colonic epithelial and immune cells.
3. To define the cellular and molecular basis by which E. histolytica adhesin, the Gal-lectin, can stimulate an effective cell-mediated immune response against ameba.
Publications
In the Lab
Shanshan Wang
MSc student
shanshan.wang1@ucalgary.ca
Hayley Gorman
PhD candidate
hayley.gorman1@ucalgary.ca
Ariel Kim
PhDstudent
ariel.kim1@ucalgary.ca
France Moreau
Lab Manager
fmoreau@ucalgary.ca
Administrative Assistant
Miwa Shibuya
HRIC 1C58
mmshibuy@ucalgary.ca
403.210.8468