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University of Calgary
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- Bernoux, D., Jayanthan, A., Bose, P., Riabowol, K. and Narendran, A.
(Cancer Cell International, In Press, 2011)
Multi-tyrosine kinase inhibitors in preclinical studies for pediatric CNS AT/RT: Evidence for synergy with Topoisomerase-1 inhibition. - Tammanai, M., Farhangi, S., Truss, M., Sinn, B., Wurm, R., Bose, P., Henze, G., Riabowol, K., von Deimling, A. and Tallen, U.G.
Oncology Research 18: 469-480 (2010)
The Inhibitor of Growth 1 (ING1) is involved in Trichostatin A-Induced Apoptosis and in Caspase 3 Signaling in p52-Deficient Glioblastoma Cells. - Kim, M., Williamson, C.T., Prudhomme, J., Bebb, D.G., Riabowol, K., Lee, P.W.K., Lees-Miller, S.P., Mori, Y., Rahman, M.M., McFadden, G., Johnston, R.N.
Oncogene 29: 3990-3996 (2010)
The viral tropism of two distinct oncolytic viruses, reovirus and myxoma virus, is modulated by cellular tumor suppressor gene status. - Suzuki, K., Bose, P., Leong-Quong, R.Y-Y., Fujita, D.J. and Riabowol, K.
BMC Research Notes 3: 294 (2010) * Designated as a “Most Highly Accessed” publication.
REAP: A two minute subcellular fractionation method. - Tallen, G., Farhangi, S., Tamannai, M., Suzuki, K., Shah, S., Holtkamp, N., Suzuki, K.,
Shah, S., Mangoldt, D., Truss, M., Henze, G., Riabowol, K. and von Deimling, A.
Oncology Research. 18:95-105 (2009)
The Inhibitor of Growth 1 (ING1) proteins suppress angiogenesis and differentially regulate angiopoietin expression in glioblastoma cells. - Luo, J., Shah, S., Riabowol, K. and Mains, PE.
Genetics. 181:473-482. (2009)
The Caenorhabditis elegans ing-3 gene regulates ionizing radiation-induced germ cell apoptosis in a p53-associated pathway. - Shah, S., Smith, H., Feng, X., Rancourt, D. and Riabowol, K.
Biochemistry & Cell Biology. 87:117-25 (2009)
ING Function in Apoptosis in Diverse Model Systems. - Tallen, G., Truss, M., Kunitz, F., Wellman, S., Unryn, B., Sinn, B., Lass, U., Krabbe, S.,
Holtkamp, N., Hagemeier, C., Wurm, R., Henze, G., Riabowol, K. and von Deimling, A.
J. Neurooncol. 86:23-30 (2008)
Down-regulation of the inhibitor of growth 1 (ING1) tumor suppressor sensitizes p53-deficient glioblastoma cells to cisplatin-induced cell death. - Walzak, A.A., Veldhoen, N., Feng, X., Riabowol, K. and Helbing, C.
Exp. Cell Res. 314: 273-285 (2008)
Expression Profiles of mRNA Transcript Variants Encoding the Human Inhibitor of
Growth Tumor Suppressor Gene Family in Normal and Neoplastic Tissues. - Sarker, K.P., Kataoka, H., Chan, A., Netherton, S.J., Pot1, I., Feng, X., Riabowol, K. and Bonni, S.
J, Biol. Chem. 283: 13269-13279 (2008)
ING2 as a Novel Mediator of TGF-b-Dependent Responses in Epithelial Cells. - Russell, M., M. Soliman, D. Schriemer and Riabowol, K.
BBRC 374:490-495 (2008)
ING1 protein targeting to the nucleus by karyopherins is necessary for activation of p21. - Bose, P. and Riabowol, K.
Trends in Cell Cycle Research pp1-30 (2008)
Replicative senescence and the aging cell cycle. - Soliman, M., Berardi, P., Pastyryeva, S., Bonnefin, P., Suzuki, K., Feng, X., Russell, M., Colina, A., Young, D. and Riabowol, K.
Aging Cell. 7:783-94. (2008)
Regulation of Chromatin Structure by Differential Expression of ING1 Splicing Isoforms during Cell Senescence. - Han, X., Feng, X., Rattner, J.B., Smith H., Bose, P., Soliman, M.S., Scott M., Burke,B.E. and Riabowol, K.
Nature Cell Biology. 10:1333-1340 (2008)
Tethering of the ING1 PHD protein to lamin A is required for ING1 stability and function in apoptosis. - Gordon, PMK., Soliman, MA, Bose, P., Trinh, Q, Sensen, CW. and Riabowol, K.
BMC Genomics. 9:426 (2008)
Interspecies data mining to predict novel protein-protein interactions in human. - Soliman, M. and Riabowol, K.
TIBS 32: 509-519 (2007)
A PHD in epigenetics after a decade of study-ING. - Tallen, G., Soliman, MA and Riabowol, K.
Rejuv. Res. 10: 387-395 (2007)
The cancer-aging interface and the significance of telomere dynamics in cancer therapy. - Gong, W., Russell, M., Suzuki, K. and Riabowol, K.
Molecular and Cellular Biology 26: 2947-2954 (2006)
Phosphorylation-dependent binding of ING1 by 14-3-3 inhibits transcriptional induction of p21 by blocking nuclear localization. - Russell, M., Berardi, P., Gong, W. and Riabowol, K.
Exp. Cell Research 312: 951-961 (2006)
Grow-ING, Age-ING and Die-ING: ING proteins link cancer, senescence and aging. - Unryn, B., Cook, L., Hao, D., Gluck, S. and Riabowol, K.
Clin Can. Res. 12:6345-6350 (2006)
Accelerated telomere loss in elderly cancer patients treated with cisplatin. - Feng, X. Bonnie, S. and Riabowol, K.
Molecular & Cellular Biology 26: 9244-9255 (2006)
Induction of HSP70 by ING Proteins Sensitizes Cells to TNFa-mediated Apoptosis. - Unryn, B., Cook, L and Riabowol, K.
Aging Cell 4: 97-101 (2005) *Recommended by the Faculty of 1000.
Paternal Age is Positively Linked to Telomere Length of Children. - He, G.H., Wagner, M., Helbing, C.C., Sensen, C.W. and Riabowol, K.
Molecular Biology & Evolution 22: 104-116 (2005)
Phylogenetic analysis of the ING family of PHD proteins. - Gong, W., Suzuki, K., Russell, M., and Riabowol, K.
International Journal of Biochemistry and Cell Biology 37: 1054-1065. (2005)
Function of the ING family of PHD proteins in cancer. - He,G., Wagner,M., Helbing,C., Sensen,C., and Riabowol,K.
Molecular Biology and Evolution 22: 104-116. (2005)
Phylogenetic analysis of the ING family of PHD finger proteins. - Quarrie,J. and Riabowol,K.
Science of Aging Knowledge Environment (SAGE-KE). (2004)
Murine models of lifespan extension. - Wheaton,K. and Riabowol,K.
Molecular and Cellular Biology 24: 7298-7311. (2004)
Protein kinase C-delta blocks immediate early gene expression in senescent cells by inactivating serum response factor. - Berardi,P., Russell,M., El-Osta,A., and Riabowol,K.
Cellular and Molecular Life Science 61: 2173-2180. (2004)
Functional links between transcription, DNA repair and apoptosis. - Tallen,G., Kaiser,I., Krabbe,S., Lass,U., Hartmann,C., Henze,G., Riabowol,K., and von Deimling,A.
International Journal of Cancer 109: 476-479. (2004)
No ING1 mutations in human brain tumors but reduced expression in high malignancy grades of astrocytoma. - Tallen,G., Riabowol,K., and Wolff,J.E.A.
Anticancer Research 23: 1631-1636. (2003)
Expression of p33ING1 mRNA and chemosensitivity in brain tumour cells - Kataoka,H., Bonnefin,P., Vieyra,D., Feng,X., Hara,Y., Miura,Y., Nakabayashi,H.,
Joh,T., Vaziri,H., Harris,C., and Riabowol,K.
Cancer Research 15: 5785-5792. (2003)
ING1 represses transcription by direct DNA binding and through effects on p53. - Vieyra,D., Senger,D., Toyama,T., Muzik,H., Brasher,P., Johnston,R.,
Riabowol,K., and Forsyth,P.
Clinical Cancer Research 9: 5952-5961. (2003)
Altered subcellular localization and low frequency of mutations of ING1 in human brain tumors. - Toyama,T., Iwase,H., Yamashita,H., Hara,Y., Sugiura,H., Zhang,Z.,
Fukai,I., Miura,Y., Riabowol,K., and Fujii,Y.
Journal of Steroid Biochemistry and Molecular Biology 87: 57-63. (2003)
p33(ING1b) stimulates the transcriptional activity of the estrogen receptor alpha via its activation function (AF) 2 domain. - Hara, Y., Zheng, Z., Evans, S., Malatjalian, D., Riddell, D., Guernsey, D.,
Wang, L., Riabowol, K. and Casson, A.
Cancer Letters 192: 109-116. (2003)
ING1 and p53 tumor suppressor gene alterations in adenocarcinomas of the esophagogastric junction. - Berardi, P., Meyyappan, M., and Riabowol, K.
Journal of Biological Chemistry 278: 7510-7519. (2003)
Senescence-specific regulation of the cyclin D1 gene by a novel transcriptional inhibitory element. - Feng, X., Hara, Y. and Riabowol, K.
Trends in Cell Biology 12: 532-538. (2002)
Different HATS of the ING1 gene family
Full text in PDF format
- Vieyra, D., Toyama, T., Hara, Y., Boland, D., Johnston, R. and Riabowol, K.
Cancer Research 62(15): 4445-52. (2002)
ING1 Isoforms Differentially Affect Apoptosis in a Cell Age-dependent Manner - Vieyra, D., Loewith, R., Scott, M., Bonnefin, P., Boisvert, F-M., Cheema, P.,
Pastyryeva S, Meijer, M., Bazett-Jones, D., McMahone, S., Cole, M.D.,Young,D. and Riabowol, K.
Journal of Biological Chemistry 277: 29832-839. (2002)
Human ING1 proteins differentially Regulate histone acetylation - Wagner, M.J., Gogela-Speher, M., Skirrow, R.C., Johnston, R.N., Riabowol, K.
and Helbing, C.C.
Journal of Biological Chemistry 276: 47013-020. (2001)
Expression of novel ING variants is regulated by thyroid hormone in the Xenopus laevis tadpole. - Nagashima, M., Shiseki, M., Miura, K., Hagiwara, K., Linke, S.P., Pedeux, R.,
Wang, X.W., Yokota, J., Riabowol, K. and Harris, C.C.
Proceedings of the National Academy of Science USA 98: 9671-9676. (2001)
DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53. - Scott, M., Bonnefin, P., Vieyra, D., Boisvert, F.M., Young, D., Bazett-Jones,
D.P. and Riabowol, K.
Journal of Cell Science 114: 3455-3462. (2001)
UV induced binding of ING1 to PCNA regulates the induction of apoptosis - Chen, L., Matsubara, N., Yoshino, T., Nagasaka, T., Hoshiztma, N., Shirakawa,
Y., Naomoto, Y., Isozaki, H., Riabowol, K. and Tanaka, N.
Cancer Research 61: 4345-4349. (2001)
Genetic alterations of the candidate tumor supressor ING1 in human esophageal squamous cell cancer - Scott, M., Boisvert, F.M., Vieyra, D., Johnston, R.N., Bazett-Jones, D.P. and Riabowol,K.
Nucleic Acids Research 29: 2052-2058. (2001)
UV induces nucleolar translocation of ING1 through two distinct nucleolar targeting sequences - Wheaton, K., Sampsel,K., Boisvert, F.M., Davy, A., Robbins,S. and Riabowol, K.
Journal of Cellular Physiology 187: 226-235. (2001)
Loss of functional caveolae during senescence of human fibroblasts - Boland, D., Olinek, V., Vieyra, D., Parr, E. and Riabowol, K.
Hybridoma 19: 161-166. (2000)
A panel of Cab antibodies recognize endogenous and ectopically expressed ING1 protein. - Bestilny, L.J. and Riabowol, K.
Experimental Cell Research 256: 264-271. (2000)
A role for serine proteases in mediating phorbol ester-induced differentiation of HL-60 Cells - Loewith, R., Meijer, M., Lees-Miller, S.P., Riabowol, K. and Young, D.
Molecular and Cellular Biology 20: 3807-3816. (2000)
Three yeast proteins related to the human candidate tumor supressor p33(ING1) are associated with histone acetyltransferase activities - Bestilny, L.J., Gill, M.J., Mody, C.H. and Riabowol, K.
AIDS 14: 771-780. (2000)
Accelerated replicative senescence of the peripheral immune system induced by HIV infection - Ma, D., Lawless, D. and Riabowol, K. (Nature Genetics 23: 373, 1999)
Correction and Addition of ING1 Splicing Varient Sequences - Meyyappan, M., Wheaton, K. and Riabowol, K. (Journal of Cellular Physiology 179: 29-39,1999)
Decreased Expression and Activity of the Immediate-Early Growth Responce
(Egr-1) Gene Product During Cellular Senescence - Ohmori, M., Nagai, M., Tasaka, T., Koeffler, H.P., Riabowol, K. and Takahara, J.
(American Journal of Hematology 62: 118-119, 1999)
Decreased Expression of p33ING1 mRNA in Lymphoid Malignancies - Toyama, T., Iwase, H., Watson, P., Muzik, H., Saettler, E., Magliocco, A.,
DiFrancesco, L., Forsyth, P., Garkavtsev, I., Kobayashi, S. and Riabowol, K.
(Oncogene 18: 5187-5193, 1999)
Suppression of ING1 expression in sporadic breast cancer - Meyyappan, M., Wong, H., Hull, C. and Riabowol, K. (Molecular and Cellular
Biology 18: 3163-3172, 1998)
Increased Expression of Cyclin D2 during Multiple States of Growth Arrest in
Primary and Established Cells - Garkavtsev, I., Hull, C., Riabowol K. (Experimental Gerontology 33: 81-94, 1998)
Molecular Aspects of the relationship between Cancer and Aging: Tumor
Supressor Activity During Cellular Senescence - Garkavtsev, I., Boland, D., Mai, J., Wilson, H., Veillette, C. and Riabowol, K. (Hybridoma 16: 537-540, 1997)
Specific Monoclonal Antibody Raised Against the p33ING1 Tumor Suppressor - Parr, E.J., Myles, E.B., Hanani, M., Seror, D., Riabowol, K. and Sharkey, K.A.
(Cell and Tissue Research 290: 21-29, 1997)
Immunoreactivity for the Fas Ligand in the Mammalian Enteric Nervous System - Helbing C.C., Veillette C., Riabowol K., Johnston R.N., Garkavstev I. (Cancer
Research 57: 1255-1258, April 1, 1997)
A Novel Candidate in Tumor Suppressor, ING1 is involved in the Regulation of Apoptosis - Garkavtsev I., Demetrick D., and Riabowol K. (Cytogenet and Cell Genet 76: 176-
178, 1997)
Cellular localization and chromosome mapping of a novel candidate tumor
suppressor gene (ING1) - Cossons, N., Nielsen, T.O., Young, D.B., Riabowol, K.T., Rattner, J.B., Johnston,
R.N., Zannis-Hadjopoulos, M. and Price, G.B. (Journal of Cellular Biochemistry 67: 439-450, 1997)
Circular YAC vectors containing small mammalian origin sequences can associate
with the nuclear matrix - Garkavtsev I., Riabowol K. (Molecular and Cellular Biology, Apr. 1997, p. 2014-
2019)
Extension of the Replicative Life Span of Human Diploid Fibroblasts by Inhibition
of the p33ING1Candidate Tumor Suppressor - Garkavtsev I., Kazarov A., Gudkov A., and Riabowol K. (Nature Genetics 14: 415-
420, December, 1996)
Suppression of novel growth inhibitor p33ING1 promotes neoplastic transformation - Bestilny, L.J., Brown, C.B., Miura, Y., Robertson, L.D. and Riabowol, K.T. (Cancer Research 56: 3797-3806, 1996)
Selective Inhibition of Telomerase Activity During Terminal Differentiation of
Immortal Cell Lines - Wong H., and Riabowol K. (Experimental Gerontology 31: 311-325, 1996)
Differential CDK-Inhibitor Gene Expression in Aging Human Diploid Fibroblasts - Edwards, D.R., Leco, K.J., Beaudry, P.P., Atadja, P.W., Veillette, C. and Riabowol,
K.T. (Experimental Gerontology 31: 207-219, 1996)
Differential effects of transforming growth factor-B1 on the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in young and old
human fibroblasts - Atadja P.W., and Riabowol K.T. (Canadian Journal on Aging 15: 31-34, 1996)
Loss of Serum Response Activity is the Basis of Reduced C-FOS Expression in
Aging Human Fibroblasts - Meyyapan M., Atadja P.W., Riabowol K.T. (Bio Signals 5:130-138,1996)
Regulation of Gene Expression and Transcriptin Factor Binding during Cellular
Aging - Wheaton, K., Atadja P., and Riabowol K. (Biochem. Cell Biol. 74: 523-534, 1996)
Regulation of transcription factor activity during cellular aging - Atadja, P.W., Wong, H., Garkavtsev, I., Veillette, C. and Riabowol, K.T.
(Proceedings of the National Academy of Sciences of the USA 92: 8348-8352,
1995)
Increased Activity of p53 in Aging Human Fibroblasts - Atadja, P.W., Wong, H., Veillette, C. and Riabowol, K.T. (Experimental Cell
Research 217: 205-216, 1995)
Overexpression of cyclin D1 blocks Proliferation of Normal Diploid Fibroblasts - Atadja P.W., Stringer K.F., and Riabowol K.T. (Molecular and Cellular Biology 14: 4991-4999, 1994)
Loss of Serum Response Element-Binding Activity and Hyperphorylation of Serum Response Factor during Cellular Aging - Wong, H. Anderson, W.D. and Riabowol, K.T. (Analytical Biochemistry 223: 251-
258, 1994)
Monitoring mRNA Expression by Polymerase Chain Reaction: The "Primer-Dropping" Method - Riabowol K., Draetta G., Brizuela L., Vandre D., and Beach D. (Oncogene 8: 1593-1602, 1993)
The cdc2 Kinase is a Nuclear Protein that is Essential for Mitosis in Mammalian
Cells - Riabowol K., Schiff J., Gilman M.Z. (Molecular and Cell Biology 89: 157-161, 1992)
Transcription factor AP-1 activity is required for initiation of synthesis and is lost
during cellular aging - Riabowol K.T. (Biochem. Cell Biol. 70: 1064-1072, 1992)
Transcription factor activity during cellular aging of human diploid fibroblasts - Riabowol, K.T., Draetta, G, Brizuela, L, Vendre, D, and Beach, D. (Cell 57: 393-
401, 1989)
The cdc2 Kinase is a Nuclear Protein that is Essential for mitosis in Mammalian
cells - Riabowol K.T., Vosatka R.J., Ziff E.B., Lamb N.J. (Molecular and Cellular Biology 8: 1670-1676, 1988)
Microinjection of fos-Specific Antibodies blocks DNA Synthesis in Fibroblast
Cells - Riabowol K. (Analytical Biochemistry 174: 601-612, 1988)
Identification of Microinjected Cells Using Biotinylated Antibodies and Strep-avidin-Conjugated Horseradish Peroxidase - Riabowol K.T., Mizze L.A., Welch W.J. (Science 242: 433-436, 1988)
Heat Shock is Lethal to Fibroblasts Microinjected with antibodies against hsp70 - Riabowol, K.T., Fink, JS, Gilman, MZ, Walsh, DA, Goodman, RH and Feramisco, JR. (Nature 336: 83-86, 19)
The Catalytic Subunit of cAMP-Dependent Protein Kinase Induces Expression of
Genes Containing cAMP-responsive Enhancer Elements - Riabowol, K.T., Shmookler-Reis, RJ, and Goldstein, S. (Age 8: 114-121, 1985)
Properties of Extrachromosomal Covalently Closed Circular DNA Isolated and
Cloned from Aged Human Fibroblasts - Riabowol, K.T., Shmookler-Reis, RJ, and Goldstein, S. (Nucleic Acids Research
13: 5563-5584, 1985)
Interspersed Repetitive and Tandemly Repetitive Sequences are Differentially Represented in Extrachromosomal Covalently Closed Circular DNA of Human
Diploid Fibroblasts
Reviews
- Atadja, P.W. and Riabowol, K.T. (Canadian Journal of Aging 15: 17-31, 1996)
Loss of Serum Response Factor Activity is the Basis of Reduced C-FOS
Expression in Aging Human Fibroblasts - Meyyappan, M., Atadja, P. and Riabowol, K. (Biological Signals 5: 130-138, 1996)
Regulation of Gene Expression in Aging Human Fibroblasts - Riabowol, K.T. (Canadian Journal of Aging 15: 1-9, 1996)
Basic Biological Aging Research in Canada: Time for Rejuvenation? Reviewed
Editorial - Wheaton, K. and Riabowol, K. (Biochem. Cell Biology 74: 523-534, 1996)
Transcription Factor Regulation During Cellular Aging - Garkavtsev, I., Hull, C.M.and Riabowol, K. (Experimental Gerontology 33: 81-94, 1998)
Molecular Aspects of the Relationship Between Cancer and Aging: Tumor Supressor Activity During Cellular Senescence - Parr, E., Toyama, T., Hull, C., Meyyappan, M., Bestilny, L., Wheaton, K. and Riabowol, K. (Current Science 74: 878-883, 1998)
Molecular Aspects of Cellular Senescence in Human Diploid Fibroblasts - Riabowol, Karl T. (Editorial Perspective: Can. J. Aging, 2000)
Biological Aging Research in Canada: Past, Present and Future - Gong, Wei, Suzuki, K., and Riabowol, K. (The International J. of Biochemistry & Cell Biol. 37: 1054-1065, 2005)
Biological roles of the ING proteins in cancer - Han, X., Berardi, P. and Riabowol, K. (Rejuvenation Research 9: 69-76, 2006)
Chromatin Modification and Senescence: linkage by tumour suppressors? - Bose, P. and Riabowol, K. (Trends in Cell Cycle Research pp1-30, 2008)
Replicative senescence and the aging cell cycle - Shah, S., Smith, H., Feng, X., Rancourt, D. and Riabowol, K. (Biochemistry & Cell Biology 87:117-125, 2009)
ING Function in Apoptosis in Diverse Model Systems - Bose, P., Ganapathy, A. and Riabowol, K. (Epigenetics of Aging pps 227-255, 2010)
Contributions of Tumor Suppressors to the Epigenetic Regulation of Aging Cells - Tallen, G. and Riabowol, K. (Current Drug Targets, 2008)
Signaling pathways of the ING proteins - Shah, S. and Riabowol, K. (Current Drug Targets 10: 385-391, 2009)
Signaling pathways of the ING proteins in apoptosis - Bose, P., Ganapathy, A. and Riabowol, K. (Epigenetics of Aging pps 227-255, 2010)
Contributions of Tumor Suppressors to the Epigenetic Regulation of Aging Cells