University of Calgary

New protein could prevent strokes

Submitted by tdroden on Tue, 2011-07-19 09:04.

Biomedical engineers uncover new information that could help prevent heart attacks and strokes

July 19, 2011

Biomedical researchers have used a device developed at the University of Calgary’s Schulich School of Engineering to uncover new clues about heart health.

A particular form of the protein Smad2 in the lining of blood vessels may help cells resist the development of cholesterol plaque that is often responsible for heart attacks and strokes. The team is now exploring ways to manipulate the Smad2 protein to create new treatments for cardiovascular disease.

This discovery would not have been possible without the use of a flow chamber, which simulates blood flow in the body. The version of the device used in this study was designed by chemical engineer Kristina Rinker and research associate Bob Shepherd.

Their findings appear in the July issue of the American Journal of Physiology – Heart and Circulatory Physiology.


WHAT: Discovery of Smad2 protein’s role in cardiovascular health
WHEN: Wednesday, July 20, 2011
10:30 a.m. to noon
WHERE: CCIT 125, Cellular and Molecular Bioengineering Laboratory
Schulich School of Engineering, University of Calgary
Enter campus from 32nd Avenue N.W.
Printable map: http://schulich.ucalgary.ca/files/schulich/ENGG-map1.pdf
INTERVIEWS: Kristina Rinker, Cellular and Molecular Bioengineering Laboratory
Bob Shepherd, research associate
SAFETY: All visitors, including media, are required to wear lab coats and safety glasses (provided).

Media Contact:
Jennifer Sowa
Schulich School of Engineering
Mobile: 403-993-8679
Email: jsowa@ucalgary.ca