Pantea Niksirat, M.Sc. Candidate.

 DEPARTMENT OF CHEMISTRY

CHEMISTRY 601/603

FINAL MSc PRESENTATION

SPEAKER:            Pantea Niksirat, MSc Candidate.

DATE:                     Monday, April 02, 2012.

TIME:                      12:30 pm.

PLACE:                  SB 324.

TITLE:                    “Complex Formation of Antitumor Active Dirhodium(II) Acetate with Small Molecules of Biological Interest”

ABSTRACT:

Dirhodium(II) acetate, consisting of Rh₂(CH₃COO)₄ complexes, is a compound with significant antitumor activities and limited side effects. Although the antitumor studies are mainly focused on its interaction with DNA, the mechanism is not yet recognized. In addition to DNA, other biological molecules such as amino acids can interact with this complex. In this presentation the interaction of Rh₂(CH₃COO)₄ with amino acids cysteine and methionine, and imidazole, the side chain of the amino acid histidine, have been investigated using different spectroscopic techniques including EXAFS, multinuclear NMR, IR, ESI-MS and UV-Vis spectroscopy.