Publications

Salman-Dilgimen A, Hardy PO, Dresser AR, Chaconas G. HrpA, a DEAH-box RNA helicase, is involved in global gene regulation in the Lyme disease spirochete. PLoS One. 2011;6(7):e22168.

Chaconas G, Kobryn K. Structure, Function, and Evolution of Linear Replicons in Borrelia. Annu Rev Microbiol, ;64:185-202, 2010

Lee WY, Moriarty TJ, Wong CH, Zhou H, Strieter RM, van Rooijen N, Chaconas G, Kubes P. An intravascular immune response to Borrelia burgdorferi involves Kupffer cells and iNKT cells. Nat Immunol 11(4):295-302, 2010

Dresser AR, Hardy PO, Chaconas G.   Investigation of the Genes Involved in Antigenic Switching at the vlsE Locus in Borrelia burgdorferi: An Essential Role for the RuvAB Branch Migrase. PLoS 5(12):e1000680, 2009

Chaconas, G. (2008), "Replication of linear plasmids in bacteria", in Clewell, D. (ed.), Biology and Significance of Plasmids: A multi-talk discussion of extrachromosomal elements in microorganisms, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London
(online at http://www.hstalks.com/?t=BL0461651-Chaconas)

Lefas G, Chaconas G. High-Throughput Screening identifies Three Inhibitor Classes of the Telomere Resolvase from the Lyme Disease Spirochete. Antimicrob Agents Chemother 53(10):4441-9, 2009 

Moriarty TJ, Chaconas G. Identification of the Determinant Conferring Permissive Substrate Usage in the Telomere Resolvase, ResT. J Biol Chem 284(35): 23293-301, 2009

Tourand Y, Deneke J, Moriarty TJ, Chaconas G. Characterization and in vitro reaction properties of 19 unique hairpin telomeres from the linear plasmids of the lyme disease spirochete. J Biol Chem 284(11): 7264-72, 2009

Norman MU, Moriarty TJ, Dresser AR, Millen B, Kubes P, Chaconas G. Molecular mechanisms involved in vascular interactions of the lyme disease pathogen in a living host.  PLoS Pathog 4(10): e1000169, 2008

Moriarty TJ, Norman MU, Colarusso P, Bankhead T, Kubes P, Chaconas G. Real-time high resolution 3D imaging of the lyme disease spirochete adhering to and escaping from the vasculature of a living host. PLoS Pathol 4(6): e1000090, 2008

Deneke J and Chaconas G. Purification and properties of the plasmic maintenance proteins from the Borrelia burgdorferi linear plasmid lp17. J Bacteriol 190(11): 3992-4000, 2008 

Bankhead T and Chaconas G. The role of VlsE antigenic variation in the Lyme disease spirochete: persistence through a mechanism that differs from other pathogens.  Mol Microbiol 65(6): 1547-1558, 2007

Tourand Y, Lee L, Chaconas G. Telomere resolution by Borrelia burgdorferi ResT through the collaborative efforts of tethered DNA binding domains. Mol Microbiol 64(3): 580-590, 2007.

Beaurepaire C, Chaconas G. Topology-dependent transcription in linear and circular plasmids of the segmented genome of Borrelia burgdorferi. Mol Microbiol.63(2):443-53, 2007

Bankhead T, Kobryn K, Chaconas G. Unexpected twist: harnessing the energy in positive supercoils to control telomere resolution.  Mol Microbiol. 62(3):895-905.2006

Tourand Y, Bankhead T, Wilson SL, Putteet-Driver AD, Barbour AG, Byram R, Rosa PA, Chaconas G.  Differential telomere processing by Borrelia telomere resolvases in vitro but not in vivo.  J Bacteriol.188(21):7378-86. 2006

Chaconas, G. Hairpin telomeres and genome plasticity in Borrelia: all mixed up in the end. Molecular Microbiology 58(3):625-35, 2005.

Kobryn, K., Burgin, A.B. and Chaconas, G. Uncoupling the chemical steps of telomere resolution by ResT. J. Biol.Chem., 280, 26788-26795, 2005.

Chaconas, G. and Chen, C.W. Replication of linear bacterial chromosomes: no longer going around in circles. The Bacterial Chromosome, edited by N. Patrick Higgins, ASM Press, p525-539, 2005.

Beaurepaire C, Chaconas G.  Mapping of essential replication functions of the linear plasmid lp17 of B. burgdorferi by targeted deletion walking.  Mol Microbiol. 57(1):132-42. 2005

Kobryn K, Burgin AB, and Chaconas G.  Uncoupling the chemical steps of telomere resolution by RestT.  J Biol Chem  280(29):26788-95. 2005

Yuan, J.F., Beniac, D.R., Chaconas, G. and Ottensmeyer, F.P.  3D Reconstruction of the Mu Transposase and the Type 1 Transpososome: A Structural Framework for Mu DNA Transposition.  Genes and Development 19, 840-852, 2005

Kobryn, K. and Chaconas, G. Fusion of hairpin telomeres by the B. burgdorferi telomere resolvase ResT: Implications for shaping a genome in flux.  Molecular Cell, 17, 783-791, 2005