Publications

Dharmani P, Leung P, Chadee K. Tumor Necrosis Factor-α and Muc2 Mucin Play Major Roles in Disease Onset and Progression in Dextran Sodium Sulphate-Induced Colitis. PLoS One. 2011;6(9):e25058.

Lejeune M, Moreau F, Chadee K.  Prostaglandin E(2) Produced by Entamoeba histolytica Signals via EP4 Receptor and Alters Claudin-4 to Increase Ion Permeability of Tight Junctions. Am J Pathol. 2011 Aug;179(2):807-18

Kissoon-Singh V, Mortimer L, Chadee K.  Entamoeba histolytica cathepsin-like enzymes : interactions with the host gut.  Adv Exp Med Biol. 712:62-83, 2011

Dharmani P, Strauss J, Ambrose C, Allen-Vercoe E, Chadee K.  Fusobacterium nucleatum Infection of Colonic Cells Stimulates MUC2 Mucin and Tumor Necrosis Factor Alpha.  Infect Immun. 79(7):2597-607, 2011.

Hou Y, Mortimer L, Chadee K.  Entamoeba histolytica cysteine proteinase 5 binds integrin on colonic cells and stimulates NFkappaB-mediated pro-inflammatory responses. J Biol Chem. 285(46):35497-504, 2010

Lourenssen S, Houpt ER, Chadee K, Blennerhassett MG.  Entamoeba histolytica infection and secreted proteins proteolytically damage enteric neurons.  Infect Immun. 78(12):5332-40, 2010

Lejeune M, Leung P, Beck PL, Chadee K.  Role of EP4 receptor and prostaglandin transporter in prostaglandin E2-induced alteration in colonic epithelial barrier integrity.  Am J Physiol Gastrointest Liver Physiol. 299(5):G1097-105, 2010

Hirota SA, Fines K, Ng J, Traboulsi D, Lee J, Ihara E, Li Y, Willmore WG, Chung D, Scully MM, Louie T, Medlicott S, Lejeune M, Chadee K, Armstrong G, Colgan SP, Muruve DA, Macdonald JA, Beck PL.  Hypoxia-inducible factor signaling provides protection in Clostridium difficile-induced intestinal Injury. Gastroenterology. 139(1):259-69.e3, 2010

Mortimer L, Chadee K. The immunopathogenesis of Entamoeba histolytica. Exp Parasitol. 126(3):366-80, 2010. 

Dharmani P, Chadee K. Biologic therapies against inflammatory bowel disease: a dysregulated immune system and the cross talk with gastrointestinal mucosa hold the key. Curr Mol Pharmacol. 1(3):195-212, 2008

Lejeune M, Rybicka JM, Chadee K. Recent discoveries in the pathogenesis and immune response toward Entamoeba histolytica. Future Microbiol 4: 105-18, 2009

Dey I, Giembycz MD, Chadee K. Prostaglandin E(2) couples through EP(4) prostanoid  receptors to induce IL-8 production in human colonic epithelial cell lines. Br J Pharmacol 156(3): 475-85, 2009

Dey I, Chadee K.  Prostaglandin E2 produced by Entamoeba histolytica binds to EP4 receptors and stimulate IL-8 production in human colonic cells.  Infect Immun 76(11):5158-63, 2008 

Ivory CP, Prystajecky M, Jobin C, Chadee K.  TLR-9 dependent macrophage activation by Entamoeba histolytica DNA. Infect Immun 76(1):289-97. 2008

Ivory CP, Chadee K. Intranasal immunization with Gal-lectin adjuvated with CpG oligodeoxynucleotides protects against Entamoeba histolytica challenge. Infect Immun 75(10): 4917-22, 2007

Kammanadiminiti SJ, Dey I, Chadee K. Induction of Monocyte Chemotatic Protein-1 in colonic epithelial cells by Entamoeba histolytica is mediated via PI3 kinase/P65 pathway. Infect Immun 75(4): 1765-70, 2007

Ivory CP, Chadee K. Activation of dendritic cells by the Gal-lectin of Entamoeba histolytica drives Th1 responses in vitro and in vivo. Eur J Immunol 37(2); 385-94.

Ivory C, Kammanadiminiti S, Chadee K. Innate resistance to Entamoeba histolytica in murine models. Trends Parasitol 23(2):46-8, 2006

Dey I, Lejeune M, Chadee K. Prostaglandin E(2) receptor distribution and function in the gastrointestinal tract. Br J Pharmacol. 149(6):611-23. 2006

Caballero-Franco C, Keller K, De Simone C, Chadee K. The VSL#3 probiotic formula induces mucin gene expression and secretion in colonic epithelial cells. Am J Physiol Gastrointest Liver Physiol. 292(1): G315-23. 2006.

Kammanadiminti SJ, Chadee K. Suppression of NF-kappa B activation by entameba histolytica in intestinal epithelial cells is mediated by heat shock protein 27. J Biol Chem. 281(36):26112-20. 2006

Lidell ME, Moncada DM, Chadee K, Hansson GC. Entamoeba histolytica cysteine proteases cleave the MUC2 mucin in its C-terminal domain and dissolve the protective colonic mucus gel.   Proc Natl Acad Sci U S A. 103(24):9298-303. 2006

Moncada D, Keller K, Ankri S, Mirelman D, Chadee K.  Antisense inhibition of Entamoeba histolytica cysteine proteases inhibits colonic mucus degradation. Gastroenterology. 130(3):721-30. 2006

Ivory CP, Keller K, Chadee K. CpG-oligodeoxynucleotide is a potent adjuvant with an Entamoeba histolytica Gal-inhibitable lectin vaccine against amoebic liver abscess in gerbils.  Infect Immun.74(1):528-36. 2006