Research

EcoliThe global objective of my research program is to gain a better understanding of how pathogenic microorganisms initiate infections. The research specifically focuses on identifying host cell receptors for bacterial cytoadhesins or exotoxins. Once host cell receptors for these microbial components have been identified it will be possible to devise novel vaccine or therapeutic agents directed at effectively shielding host tissues from bacteria or their toxins. The model systems being investigated are enterotoxigenic Escherichia coli (ETEC, Traveller's Diarrhea), pertussis toxin (Whooping Cough), enteropathogenic Escherichia coli (EPEC, gastroenteritis in children) and enterohemorrhagic Escherichia coli (EHEC) which cause hemorrhagic colitis and, occasionally, hemolytic-uremic syndrome ("Hamburger Disease" or "Barbecue Syndrome"). Research into pathogenic mechanisms in Campylobacter species (gastroenteritis in children and adults), Cryptosporidium (intestinal parasite in AIDS) and Clostridium difficile (antibiotic-associated pseudomembranous colitis) has also been recently initiated.

If you want to learn more about the latest infections see articles listed on the CDC Home Page. Useful information concerning potential bioterrorism agents can be obtained from the following sites Health Canada and American Society for Microbiology Public Policy.

Photo of Scanning EM of Escherichia coli O157 courtesy of Richard Sherburne, Colourization by Diane Fothergill