Publications

Dingle TC, Mulvey GL, Armstrong GD. Mutagenic Analysis of the Clostridium difficile Flagellar Proteins, FliC and FliD, and Their Contribution to Virulence in Hamsters.  Infect Immun. 2011 Oct;79(10):4061-7.

Griener TP, Strecker JG, Humphries RM, Mulvey GL, Fuentealba C, Hancock RE, Armstrong GD.  Lipopolysaccharide renders transgenic mice expressing human serum amyloid p component sensitive to shiga toxin 2.  PLoS One; 6(6):e21457, 2011

Mulvey GL, Dingle TC, Fang L, Strecker J, Armstrong GD. Therapeutic potential of egg yolk antibodies for treating Clostridium difficile infection. J Med Microbiol. 2011 Aug;60(Pt 8):1181-7

Humphries RM, Armstrong GD.  Sticky situation: localized adherence of enteropathogenic Escherichia coli to the small intestine epithelium.  Future Microbiol. 5:1645-61, 2010

Humphries RM, Griener TP, Vogt SL, Mulvey GL, Raivio T, Donnenberg MS, Kitov PI, Surette M, Armstrong GD. N-acetyllactosamine-induced retraction of bundle-forming pili regulates virulence-associated gene expression in enteropathogenic Escherichia coli.  Mol Microbiol. 76(5):1111-26, 2010 

Vogt SL, Nevesinjac AZ, Humphries RM, Donnenberg MS, Armstrong GD and Raivio TL, The Cpx envelope stress response both facilitates and inhibits elaboration of the enteropathogenic Escherichia coli bundle-forming pilus.The Cpx envelope stress response both facilitates and inhibits elaboration of the enteropathogenic Escherichia coli bundle-forming pilus.  Mol Microbiol [Epub ahead of print]

Dingle T, Mulvey GL, Humphries RM, Armstrong GD. A real-time quantitative PCR assay for evaluating Clostridium difficile adherence to differentiated intestinal Caco-2 cells. J Med Microbiol, 59(Pt 8):920-4, 2010 

Ng J, Hirota SA, Gross O, Li Y, Ulke-Lemee A, Potentier MS, Schenck LP, Vilaysane A, Seamone ME, Feng H, Armstrong GD, Tschopp J, MacDonald JA, Muruve DA and Beck PL. Clostridium difficile toxin-induced inflammation and intestinal injury are mediated by the inflammasome.  Gastroenterology, 139(2):542-52, 552.e1-3, 2010

Humphries RM, Waterhouse CC, Mulvey G, Beck P, Armstrong GD. Interactions of enteropathogenic Escherichia coli with pediatric and adult intestinal biopsy specimens during early adherence. Infect Immun 77(10):4463-8. 2009  

Humphries RM, Donnenberg MS, Strecker J, Kitova E, Klassen JS, Cui L, Griener TP, Mulvey GL, Armstrong GD. From alpha to beta: identification of amino acids required for the N-acetyllactosamine-specific lectin-like activity of bundlin. Mol Microbiol 72(4): 859-68, 2009 

Kitova En, Mulvey GL, Dingle T, Sinelnikov I, Wee S, Griener TP, Armstrong GD, Klassen JS. Assemby and stability of the shiga toxins investigated by electrospray ionization mass spectrometry. Biochemistry 48(23): 5365-74, 2009. 

Kitov PI, Mulvey GL, Griener TP, Lipinski T, Solomon D, Paszkiewicz E, Jacobson JM, Sadowska JM, Suzuki M, Yamamura K, Armstrong GD, Bundle DR. In vivo supramolecular templating enhances the activity of multivalent ligands: a potential therapeutic against the Escherichia coli O157 AB5 toxins. Proc Natl Acad Sci USA 105(44): 16837-42, 2008

Hyland RM, Armstrong GD. The phosphate transport system of enteropathogenic Escherichia coli is involved in adherence to the host. Future Microbiol 3: 497-501, 2008. 

Dingle T, Wee S, Mulvey GL, Greco A, Kotova EN, Sun J, Lin S, Klassen JS, Palcic MM, Ng KK, Armstrong GD.  Functional properties of the carboxy-terminal host cell binding domains of the two toxins, TcdA and TcdB, expressed by Clostridium difficile. Glycobiology 18(9):698-706, 2008 

Kitov PI, Lipinski T, Paszkiewicz E, Solomon D, Sadowska JM, Grant GA, Mulvey GL, Kitova EN, Klassen JS, Armstrong GD, Bundle DR. An entropically efficient supramolecular inhibition strategy for Shiga toxins. Angew Chem Int Ed Engl 47(4): 672-6, 2008.

Hyland RM, Sun J, Griener TP, Mulvey GL, Klassen JS, Donnenberg MS, Armstrong GD. The bundlin pilin protein of enteropathogenic Escherichia coli is an N-acetyllactosamine-specific lectin. Cell Microbiol 10(1):177-87, 2008

Griener TP, Mulvey GL, Marcato P, Armstrong GD.   Differential binding of Shiga toxin 2 to human and murine neutrophils. J Med Microbiol 56(Pt 11):1423-30, 2007.

Armstrong GD, Mulvey GL, Marcato P, Griener TP, Kahan MC, Tennent GA, Sabin CA, Chart H, Pepys MB.  Human Serum Amyloid P Component Protects against Escherichia coli O157:H7 Shiga Toxin 2 In Vivo: Therapeutic Implications for Hemolytic-Uremic Syndrome.   J Infect Dis. 193(8):1120-4. 2006. 

Hyland RM, Griener TP, Mulvey GL, Kitov PI, Srivastava OP, Marcato P, Armstrong GD.  Basis for N-acetyllactosamine-mediated inhibition of enteropathogenic Escherichia coli localized adherence.   J Med Microbiol. 5(Pt 6):669-75. 2006

Fraser ME, Cherney MM, Marcato P, Mulvey GL, Armstrong GD, James MN.  Binding of adenine to Stx2, the protein toxin from Escherichia coli O157:H7.  Acta Crystallograph Sect F Struct Biol Cryst Commun. 62(Pt 7):627-30. 2006

Hyland RM, Beck P, Mulvey GL, Kitov PI, Armstrong GD.  N-acetyllactosamine conjugated to gold nanoparticles inhibits enteropathogenic Escherichia coli colonization of the epithelium in human intestinal biopsy specimens. Infect Immun. 74(9):5419-21, 2006

Shoaf K, Mulvey GL, Armstrong GD, Hutkins RW.  Prebiotic galactooligosaccharides reduce adherence of Enteropathogenic Escherichia coli to tissue culture cells.  Infect Immun 74(12): 6920-8, 2006