Wet Ink

 

 

Highlighting the latest publications from our faculty and trainees

February 2012 Publications

 

Neuronal expression of class 6 semaphorins in zebrafish. Ebert AM, Lamont RE, Childs SJ, McFarlane S. Gene Expr Patterns. 2012 Feb 6. [Epub ahead of print] PMID: 22330030 [PubMed - as supplied by publisher]

January 2012 Publications

Cluny, N.L., et al. Cannabinoid signalling regulates inflammation and energy balance: The importance of the brain–gut axis. Brain Behav. Immun. (2012) 

Introgression of Ivermectin Resistance Genes into a SusceptibleHaemonchus contortus Strain by Multiple Backcrossing Elizabeth Redman 1., Neil Sargison2.¤, Fiona Whitelaw1, Frank Jackson2, Alison Morrison2 David Jon Bartley 2, John Stuart Gilleard3

 

Diversity in parasitic nematode genomes: the microRNAs of Brugia pahangi and Haemonchus contortus are largely novel Alan D Winter 1*, William Weir1, Martin Hunt2, Matthew Berriman2, John S Gilleard3, Eileen Devaney1* and Collette Britton 1*

The Transcriptional Response of Caenorhabditis elegans to Ivermectin Exposure Identifies Novel Genes Involved in the Response to Reduced Food Intake Steven T. Laing 1, Al Ivens2, Victoria Butler3, Sai P. Ravikumar3, Roz Laing1, Debra J. Woods4, John S.Gilleard*

 

E. Ihara, M. Chappellaz, S.R. Turner and J.A. MacDonald. (2012) Protein kinase C and CPI-17 signaling pathways contribute to hypercontractility in murine colitis. Neurogastroenterology & Motility 24: e15-26.

J.A. Hirota, S.A. Hirota, S.M. Warner, D. Stefanowicz, F. Shaheen, P.L. Beck, J.A. MacDonald, T.-L. Hackett, D.D. Sin, S. VanEeden and D.A. Knight. (2012) The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter. J Allergy Clin Immunol [Epub ahead of print]

Thomas, B., Nishikawa, S., Ito, K., Chopra, P., Sharma, N., Evans, D.H., Tyrell, B.L., Bathe, O.F. and Rancourt, D.E. ‘Peptide vaccination is superior to genetic vaccination using a recombineered bacteriophage Lambda subunit vaccine’ Vaccine (2012) 30 (6) 998-1008

Collagen I Scaffolds Cross-Linked with Beta-Glycerol Phosphate Induce Osteogenic Differentiation of Embryonic Stem Cells In Vitro and Regulate Their Tumorigenic Potential In Vivo. Krawetz RJ, Taiani JT, Wu YE, Liu S, Meng G, Matyas JR, Rancourt DE. Tissue Eng Part A. 2012 Jan 26. [Epub ahead of print]

Synergistic Effect of Medium, Matrix, and Exogenous Factors on the Adhesion and Growth of Human Pluripotent Stem Cells Under Defined, Xeno-Free Conditions. Meng G, Liu S, Rancourt DE. Stem Cells Dev. 2012 Jan 26. [Epub ahead of print]

 

December Publications

 

The potential role of prebiotic fibre for treatment and management of non-alcoholic fatty liver disease and associated obesity and insulin resistance. Parnell JA, Raman M, Rioux KP, Reimer RA. Liver Int. 2011 Dec 30. doi: 10.1111/j.1478-3231.2011.02730.x

βPix plays a dual role in cerebral vascular stability and angiogenesis, and interacts with integrin α(v)β(8). Liu J, Zeng L, Kennedy RM, Gruenig NM, Childs SJ. Dev Biol. 2012 Mar 1;363(1):95-105. Epub 2011 Dec 22. PMID: 22206757 [PubMed - in process]

Sharma, N., Kumar, R., Renaux, B., Saifeddin, M., Nishikawa, S., Ramachandran, R., Hollenberg, MD and Rancourt, D. ‘Implantation Serine Proteinase 1 shows mixed substrate specificity and can silence the signalling through Proteinase Activated Receptors’ PLOS One (2011) 6 (11) e27888

Impact of stirred suspension bioreactor culture on the differentiation of murine embryonic stem cells into cardiomyocytes. Shafa M, Krawetz R, Zhang Y, Rattner JB, Godollei A, Duff HJ, Rancourt DE. BMC Cell Biol. 2011 Dec 14;12:53.

 

November Publications

Borysova, L., Shabir, S., Walsh, M. P. and Burdyga, T. (2011) Cell Calcium 50: 393-405. The importance of Rho-associated kinase-induced Ca2+ sensitization as a component of electromechanical and pharmacomechanical coupling in in rat ureteric smooth muscle.

 Use of diagnostic markers to monitor fasciolosis and gastrointestinal nematodes on an organic dairy farm. Ellis KA, Jackson A, Bexiga R, Matthews J, McGoldrick J, Gilleard J, Forbes AB. Vet Rec. 2011 Nov 12;169(20):524. doi: 10.1136/vr.d5021. Epub 2011 Sep 9.

 Moffat, L. D., Brown, S., Grassie, M., Ulke-Lemée, A., Williamson, L., Walsh, M. P. and MacDonald, J. A. (2011) J. Biol. Chem. 286: 36978-36991.Chemical genetics of zipper-interacting protein kinase reveal myosin light chain as a bona fide substrate in permeabilized arterial smooth muscle.

Inhibition of Rho kinase regulates specification of early differentiation events in P19 embryonal carcinoma stem cells. Krawetz RJ, Taiani J, Greene A, Kelly GM, Rancourt DE. PLoS One. 2011;6(11):e26484. Epub 2011 Nov 30.

Implantation serine proteinase 1 exhibits mixed substrate specificity that silences signaling via proteinase-activated receptors. Sharma N, Kumar R, Renaux B, Saifeddine M, Nishikawa S, Mihara K, Ramachandran R, Hollenberg MD, Rancourt DE. PLoS One. 2011;6(11):e27888. Epub 2011 Nov 23.

October Publications

Annotation of two large contiguous regions from the Haemonchus contortus genome using RNA-seq and comparative analysis with Caenorhabditis elegans. Laing R, Hunt M, Protasio AV, Saunders G, Mungall K, Laing S, Jackson F, Quail M, Beech R, Berriman M, Gilleard JS. PLoS One. 2011;6(8):e23216. Epub 2011 Aug 15.

 

September Publications

 

Effects of the soluble fiber complex PolyGlycopleX® on glucose homeostasis and body weight in young Zucker diabetic rats Gary James Grover 1,2*, Lee Koetzner1, Joan Wicks3, Roland J. Gahler4, Michael R. Lyon5,6, Raylene A. Reimer7 and SimonWood5

August Publications

Chemical genetics of zipper-interacting protein kinase reveal myosin light chain as a bona fide substrate in permeabilized arterial smooth muscle J. Biol. Chem. 2011 jbc.M111.257949. First Published on August 31, 2011, doi:10.1074/jbc.M111.257949 Lori D. Moffat, Shannon B.A. Brown, Michael E. Grassie, Annegret Ulke-Lemee, Laura M. Williamson, Michael P. Walsh and Justin A. MacDonald

Annotation of Two Large Contiguous Regions from the Haemonchus contortus Genome Using RNA-seq and Comparative Analysis with Caenorhabditis elegans.Laing R, Hunt M, Protasio AV, Saunders G, Mungall K, Laing S, Jackson F, Quail M, Beech R, Berriman M, Gilleard JS. PLoS One. 2011;6(8): e23216

Walsh, M.P., Thornbury, K., Cole, W.C., Sergeant, G., Hollywood, M. and  McHale, N. (2011) Am. J. Physiol. 300: F73-F85. Rho-associated kinase  plays a role in rabbit urethral smooth muscle contraction, but not via  enhanced myosin light chain phosphorylation

 Gao, G., Li, J-J., Li, Y., Li, D., Wang, Y., Wang, L., Tang, X.D., Walsh,  M.P., Gui, Y. and Zheng, X-L. (2011) Am. J. Physiol. 300: H1583-H1594. Rapamycin inhibits hydrogen peroxide-induced loss of vascular contractility. Hannigan, G.E., McDonald, P.C., Walsh, M.P. and Dedhar, S. (2011)

 Oncogene: doi:10.1038/onc.2011.177. Integrin-linked kinase: not so  “pseudo” after all.Borysova, L., Shabir, S., Walsh, M.P. and Burdyga, T. (2011) Cell Calcium: doi: 10.1016/j.ceca.2011.07.003.

The importance of Rho-associated  kinase-induced Ca2+ sensitization as a component of electromechanical and pharmacomechanical coupling in in rat ureteric smooth muscle. Anfinogenova, Y., Brett, S.E., Walsh, M.P., Harraz, O.F. and Welsh, D.G. (2011) Am. J. Physiol.: doi:10.1152/ajpheart.00460.2011.

Do TRPC-like currents and G-protein coupled receptors interact to facilitate myogenic tone development?Gui, Y., Wang, Z-Y., Sun, X-R., Walsh, M.P., Li, J-J., Gao, J. and Zheng, X-L. (2011) Am. J. Physiol.: doi:10.1152/ajplung.00203.2011.

Uridine adenosine tetraphosphate induces contraction of airway smooth muscle. Tejani, A. D., Walsh, M. P. and Rembold, C. M. (2011) Am. J. Physiol. doi:10.1152/ajpcell.00149.2011. Tissue length modulates “stimulated actin polymerization”, force augmentation, and the rate of swine carotid artery contraction.

53BP1-mediated DNA double strand break repair: Insert bad pun here. Noon AT, Goodarzi AA. DNA Repair (Amst). 2011 Aug 23. [Epub ahead of print] PMID: 21868291 [PubMed - as supplied by publisher]

Analysis of human syndromes with disordered chromatin reveals the impact of heterochromatin on the efficacy of ATM-dependent G2/M checkpoint arrest. Brunton H, Goodarzi AA, Noon AT, Shrikhande A, Hansen RS, Jeggo PA, Shibata A. Mol Cell Biol. 2011 Jul 25. [Epub ahead of print]

Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage. Zolner AE, Abdou I, Ye R, Mani RS, Fanta M, Yu Y, Douglas P, Tahbaz N, Fang S, Dobbs T, Wang C, Morrice N, Hendzel MJ, Weinfeld M, Lees-Miller SP. Nucleic Acids Res. 2011 Aug 8. [Epub ahead of print] PMID: 21824916

 

July Publications

 Prebiotic fibres dose-dependently increase satiety hormones and alter Bacteroidetes and Firmicutes inlean and obese JCR:LA-cp rats Jill A. Parnell 1 and Raylene A. Reimer2

 XRCC4 interactions with XRCC4-like factor (XLF) create an extended grooved scaffold for DNA ligation and double-strand break repair. Hammel M, Rey M, Yu Y, Mani RS, Classen S, Liu M, Pique ME, Fang S, Mahaney B, Weinfeld M, Schriemer DC, Lees-Miller SP, Tainer JA. J Biol Chem. 2011 Jul 20. [Epub ahead of print] PMID:21775435

 Expansion and long-term maintenance of induced pluripotent stem cells in stirred suspension bioreactors. Shafa M, Sjonnesen K, Yamashita A, Liu S, Michalak M, Kallos MS, Rancourt DE.J Tissue Eng Regen Med. 2011 Jul 14. doi: 10.1002/term.450. [Epub ahead of print]

 

 

  June Publications

Ornithine Decarboxylase AntizymeOaz3 Modulates Protein Phosphatase Activity Received for publication, June 21, 2011 Published, JBC Papers in Press, June 28, 2011, DOI 10.1074/jbc.M111.274647  Yibing Ruan, Min Cheng, Young Ou, Richard Oko, and Frans A. van der Hoorn1.

 

ZENG*, W., C. BAUMANN*, A. SCHMIDTMANN, A. HONARAMOOZ, L. TANG, A. BONDAREVA, C. DORES, T. FAN, S. XI, T. GEIMAN, R. RATHI, D. DE ROOIJ, R. DE LA FUENTE, K. MUEGGE & I. DOBRINSKI (2011): Lymphoid specific helicase (HELLS) is essential for meiotic progression in mouse spermatocytes. Biol.Reprod. 84: 1235-1241. *equal contribution

Suzuki, K., Boland, D., Gong, W and Riabowol, K. "Domain recognition of the ING1 tumor suppressor by a panel of monoclonal antibodies". Hybridoma 30:239-245 (June, 2011).

Thalappilly, S., Feng, X., Pastyryeva, S., Vieyra, D., Bonnefin, P., von Deimling, A., Truss, M., Muruve, D., Laroque, D., Richard S., Riabowol, K. and Tallen, G., The p53 tumor suppressor is stabilized by inhibitor of growth 1 (ING1) by blocking polyubiquitination. Plos One 10.1371/journal.pone.0021065 (June 22, 2011).

McCoy, K.E., Zhou, X. and Vize, P.D. (2011). Non-canonical wnt signals antagonize and canonical wnt signals promote cell proliferation in early kidney development. Developmental Dynamics 240; 1558-1566

MAPKs represent novel therapeutic targets for gastrointestinal motility disorders. Ihara E, Akiho H, Nakamura K, Turner SR, MacDonald JA. World J Gastrointest Pathophysiol. 2011 15;2(2):19-25.

Guest editorial & introduction to the special issue "Protein kinases and phosphatases: regulators of motile systems". Walsh MP, MacDonald JA. Arch Biochem Biophys. 2011 15;510(2):73-5

Differential effects of salvinorin A on endotoxin-induced hypermotility and neurogenic ion transport in mouse ileum. Fichna J, Dicay M, Hirota SA, Traboulsi D, MacDonald JA, Janecka A, Beck PL, Zjawiony JK, Macnaughton WK, Storr MA. Neurogastroenterol Motil. 2011 23(6):583-e212.

 

 

April Publications

 

Simultaneous siRNA Targeting of Src and Downstream Signaling Molecules InhibitTumor Formation and Metastasis of a Human Model Breast Cancer Cell Line
Jeffrey D. Bjorge, Andy S. Pang, Melanie Funnell, Ke Yun Chen, Roman Diaz, Anthony M. Magliocco, Donald J. Fujita  PLoS ONE:   Published 26 Apr 2011

Park M, Youn B, Zheng X-L, Wu D, Xu A, Sweeney G. Globular Adiponectin, Acting via AdipoR1/APPL1, Protects H9c2 Cells from Hypoxia/Reoxygenation-Induced Apoptosis. PLoS ONE Apr 28, 2011;6:e19143.

Yao B, Li S, Lian SL, Fritzler MJ, Chan EK. Mapping of Ago2-GW182 Functional Interactions. Methods Mol Biol. 2011;725:45-62. PMID: 21528446

Yao B, Li S, Jung HM, Lian SL, Abadal GX, Han F, Fritzler MJ, Chan EK. . Divergent GW182 functional domains in the regulation of translational silencing. Nucleic Acids Res. 2011 Apr 1;39(7):2534-47. PMID: 21131274

 

 

March Publications

 

1)H NMR metabolomics identification of markers of hypoxia-induced metabolic shifts in a breast cancer model system. Weljie AM, Bondareva A, Zang P, Jirik FR. J Biomol NMR. 2011 Apr;49(3-4):185-93. Epub 2011 Mar 4.

Huynh, M.A., Ikeuchi, Y., Netherton, S., Torre-Ubeita, L. Kanadia, R., Stegmuller, J., Cepko, C., Bonni, S., Bonni, A. (2011) An isoform-specific SnoN1-FOXO1 repressor complex controls neuronal morphogenesis and positioning in the mammalian brain. Neuron. March 10; 69(5):930-44    

The soluble fiber complex PolyGlycopleX lowers serum triglycerides and reduces hepatic steatosis in high-sucrose-fed rats Raylene A. Reimer a,⁎, Gary J. Grover b,c, Lee Koetzner c, Roland J. Gahler d, Michael R. Lyone,f, Simon Woode

Hudson M, Baron M, Fritzler MJ; Canadian Scleroderma Research Group (CSRG), Steele R. Observational data to study medication outcomes in systemic sclerosis. J Rheumatol. 2011 Mar;38(3):575-7. PMID: 21362793

 

Efficient suspension bioreactor expansion of murine embryonic stem cells on microcarriers in serum-free medium. Alfred R, Radford J, Fan J, Boon K, Krawetz R, Rancourt D, Kallos MS. Biotechnol Prog. 2011 Mar 21. doi: 10.1002/btpr.591. [Epub ahead of print] PMID: 21538971

 

                   

 

February Publications 

 

 

Huynh, M.A., Ikeuchi, Y*., Netherton, S.*, Torre-Ubeita, L*. Kanadia, R., Stegmuller, J., Cepko, C., Bonni, S., Bonni, A.  An isoform-specific SnoN1-FOXO1 repressor complex controls neuronal morphogenesis and positioning in the mammalian brain. Neuron. 2011 March 10; 69(5):930-44.    * Equal contributers to the work

Prion protein expression level alters regional copper, iron and zinc content in the mouse brain. Pushie MJ, Pickering IJ, Martin GR, Tsutsui S, Jirik FR, George GN. Metallomics. 2011 Feb; 3(2):206-14.

PTEN deletion and heme oxygenase-1 overexpression cooperate in prostate cancer progression and are associated with adverse clinical outcome. Li Y, Su J, Dingzhang X, Zhang J, Yoshimoto M, Liu S, ijian K, Gupta A, Squire JA, Alaoui Jamali MA, Bismar TA. J Pathol. 2011 Jan 10. doi: 10.1002/path.2855. [Epub ahead of print] PMID: 21381033 [PubMed - as supplied by publisher]

Related citations

Detection of ERG gene rearrangements and PTEN deletions in unsuspected prostate cancer of the transition zone.Liu S, Yoshimoto M, Trpkov K, Duan Q, Firszt M, Corcos J, Squire JA, Bismar TA.Cancer Biol Ther. 2011 Mar 15;11(6). [Epub ahead of print] PMID: 21178509 [PubMed - as supplied by publisher]

Zeng^*, W., C. Baumann*,  A. Schmidtmann,  A. Honaramooz, L. Tang, A. Bondareva, C. Dores, T. Fan, S. Xi, T. Geiman, R. Rathi, D. de Rooij, R. De La Fuente,  K.  Muegge& i. dobrinski (2011): Lymphoid specific helicase (HELLS) is essential for meiotic progression in mouse spermatocytes. Biol. Reprod. (published 23 February 2011, 10.1095/biolreprod.110.085720). *equal contribution

Rapamycin inhibits hydrogen peroxide-induced loss of vascular contractility.
Gao G, Li JJ, Li Y, Li D, Wang Y, Wang L, Tang XD, Walsh MP, Gui Y, Zheng XL.
Am J Physiol Heart Circ Physiol. 2011 Feb 25. [Epub ahead of print]

Sun, Y., Ou, Y., Cheng, M., Ruan, Y., and van der Hoorn, F.A. (2011) Binding of nickel to testicular glutamate-ammonia ligase inhibits its enzymatic activity. Mol. Reprod. Dev., 78, 104-115. (Feb)

Mapping and functional characterization of the murine Smoothelin-like 1 promoter. Ulke-Lemée A, Turner SR, Mughal SH, Borman MA, Winkfein RJ, Macdonald JA. BMC Mol Biol. 2011 Feb 27;12:10.

The myosin phosphatase targeting protein (MYPT) family: A regulated mechanism for achieving substrate specificity of the catalytic subunit of protein phosphatase type 1δ Grassie ME, Moffat LD, Walsh MP, Macdonald JA. Arch Biochem Biophys. 2011 Feb 1. [Epub ahead of print]

 

 

 

 

January Publications

 

J.R. Ryu, N. Najand, and W.J Brook. 2011. Tinman is a direct activtaor of midline expression in the Drosophila dorsal vessel. Developmental Dynamics, 240, 86-95. 

Carbon and sulfur cycling by microbial communities in a gypsum-treated oil sands tailings pond.Ramos-Padrón E, Bordenave S, Lin S, Bhaskar IM, Dong X, Sensen CW, Fournier J, Voordouw G, Gieg LM.  Environ Sci Technol. 2011 Jan 15;45(2):439-46. Epub 2010 Dec 3.

 

The neutral cannabinoid CB1 receptor antagonist AM4113 regulates body weight through changes in energy intake in the rat.  Nina L. Cluny a,1, Adam P. Chambers a,1,2, V. Kiran Vemuri b, JodiAnne T. Wood b, Lindsay K. Eller c, Carmelina Freni b, Raylene A. Reimer c, Alexandros Makriyannis b,⁎, Keith A. Sharkey. Pharmacology, Biochemistry and Behavior 97 (2011) 537–543

 

Prion protein expression level alters regional copper, iron and zinc content in the mouse brain. Pushie MJ, Pickering IJ, Martin GR, Tsutsui S, Jirik FR, George GN. Metallomics. 2011 Jan 24. [Epub ahead of print]

The Cytoskeletal Protein Ndel1 Regulates Dynamin 2 GTPase Activity. Chansard M, Wang J, Tran HC, Neumayer G, Shim SY, Park YU, Belzil C, Le HT, Park SK, Nguyen MD. PLoS One. 2011 Jan 25;6(1):e14583.

 

 

December Publications

 

 

Increased expression of tuberin in human uterine leiomyoma. Cui L, Ren Y, Yin H, Wang Y, Li D, Liu M, Zhu Y, Lin W, Tang XD, Gui Y, Zheng XL. Fertil Steril. 2010 Dec 8. [Epub ahead of print]

Kim M, Garant KA, zur Nieden, N, Alain T, Loken SD, Urbanski SJ, Forsyth PA, Rancourt DE, Lee PWK, and Johnston RN.  Attenuated reovirus displays oncolysis with reduced host toxicity. Br J Cancer 2010 Dec 21. [Epub ahead of print].

Meng G, Liu S, and Rancourt DE. Rapid isolation of undifferentiated human pluripotent stem cells from extremely differentiated colonies. Stem Cells Dev 2010 Dec 13. [Epub ahead of print].

Divergent GW182 functional domains in the regulation of translational silencing.Yao B, Li S, Jung HM, Lian SL, Abadal GX, Han F, Fritzler MJ, Chan EK. Nucleic Acids Res. 2010 Dec 2. [Epub ahead of print]PMID: 21131274

 

 

November Publications

 

 

Netherton, S. J., Bonni, S. (2010) Suppression of TGFβ-induced epithelial-mesenchymal transition like phenotype by a PIAS1 regulated sumoylation pathway in NMuMG epithelial cells. PLoS ONE  Nov 12;5 (11):  e13971 - Evaluated by F1000.

zur Nieden NI, Dacks LA, and Rancourt, DE. (2010) Monolayer cultivation of osteoprogenitors shortens duration of the embryonic stem cell test while reliably predicting developmental osteotoxicity. Toxicol 277: 66-73.

REAP: A two minute cell fractionation method. Suzuki K, Bose P,Leong-Quong RY, Fujita DJ, Riabowol K. BMC Res Notes. 2010 Nov 10;3(1):294. [Epub ahead of print] PMID: 21067583

The inhibitor of growth 1 (ING1) is involved in trichostatin A-induced apoptosis and caspase 3 signaling in p53-deficient glioblastoma cells.Tamannai M, Farhangi S, Truss M, Sinn B, Wurm R, Bose P, Henze G, Riabowol K, von Deimling A, Tallen G. Oncology Res. 2010;18(10):469-80.PMID: 20681406

XLF Regulates Filament Architecture of the XRCC4·Ligase IV Complex. Hammel M, Yu Y, Fang S, Lees-Miller SP, Tainer JA. Structure. 2010 Nov 10;18(11):1431-42.PMID: 210709 PubMed in process]Related citations[ ]

Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks. Williams GJ, Lees-Miller SP, Tainer JA. DNA Repair (Amst). 2010 Oct 27. [Epub ahead of print]PMID: 21035407 [PubMed - as supplied by publisher]Related citations  [ ]3.

A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation. Dobbs TA, Tainer JA, Lees-Miller SP. DNA Repair (Amst). 2010 Oct 26. [Epub ahead of print]PMID: 21030321 [PubMed - as supplied by publisher]Related citations[ ]4.

Low ERCC1 mRNA and protein expression are associated with worse survival in cervical cancer patients treated with radiation alone. Doll CM, Prystajecky M, Eliasziw M, Klimowicz AC, Petrillo SK, Craighead PS, Hao D, Diaz R, Lees-Miller SP, Magliocco AM.Radiother Oncol. 2010 Nov;97(2):352-9. Epub 2010 Oct 9.PMID: 20934765 [PubMed - in process]Related citations[ ]5.

Dual Modes of Interaction between XRCC4 and Polynucleotide Kinase/Phosphatase: IMPLICATIONS FOR NONHOMOLOGOUS END JOINING. Mani RS, Yu Y, Fang S, Lu M, Fanta M, Zolner AE, Tahbaz N, Ramsden DA, Litchfield DW, Lees-Miller SP, Weinfeld M.J Biol Chem. 2010 Nov 26;285(48):37619-29. Epub 2010 Sep 17.PMID: 20852255 [PubMed - in process]Free ArticleRelated citations

Stinton LM, Swain M, Myers RP, Shaheen AA, Fritzler MJ.Autoantibodies to GW bodies and other autoantigens in primary biliary cirrhosis.Clin Exp Immunol. 2010 Nov 22. doi: 10.1111/j.1365-2249.2010.04288.x. [Epub ahead of print]  PMID: 21091667

Mahler M, Silverman ED, Fritzler MJ. Novel diagnostic and clinical aspects of anti-PCNA antibodies detected by novel detection methods. Lupus. 2010 Nov;19(13):1527-33. Epub 2010 Jul 20. PMID: 20647252

Yin H, Jiang Y, Li H, Li J, Gui Y, Zheng XL. Proteasomal degradation of myocardin is required for its transcriptional activity in vascular smooth muscle cells. J Cell Physiol. 2010 Nov 10;. [Epub ahead of print]

Chen J, Yin H, Jiang Y, Radhakrishnan SK, Huang ZP, Li J, Shi Z, Catharina EP, Gui Y, Wang DZ, Zheng XL. Induction of MicroRNA-1 by Myocardin in Smooth Muscle Cells Inhibits Cell Proliferation. Arterioscler Thromb Vasc Biol. 2010 Nov 4;. [Epub ahead of print]

 

 

October Publications

 

Pot, I., Ikeuchi, Y., Bonni A., Bonni, S. (2010) SnoN: Bridging Neurobiology and Cancer Biology. Curr. Mol. Med. 10 (7):667-73- 

Characterization of the xenobiotic response of Caenorhabditis elegans to the anthelmintic drug albendazole and the identification of novel drug glucoside metabolites. Laing ST, Ivens A, Laing R, Ravikumar SP, Butler V, Woods DJ, Gilleard JS. Biochem J. 2010 Oct 8. [Epub ahead of print]

Rapid isolation of undifferentiated human pluripotent stem cells from extremely differentiated colonies. Meng G, Liu S, Rancourt DE. Stem Cells Dev. 2010 Oct 26. [Epub ahead of print]

Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasion. Xu Y, Bismar TA, Su J, Xu B, Kristiansen G, Varga Z, Teng L, Ingber DE, Mammoto A, Kumar R, Alaoui-Jamali MA. J Exp Med. 2010 Oct 11. [Epub ahead of print]

 

September Publications

 

 

NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis.Hirota SA, Ng J, Lueng A, Khajah M, Parhar K, Li Y, Lam V, Potentier MS, Ng K, Bawa M, McCafferty DM, Rioux KP, Ghosh S, Xavier RJ, Colgan SP, Tschopp J, Muruve D, MacDonald JA, Beck PL.Inflamm Bowel Dis. 2010 Sep 24. [Epub ahead of print]

Maydan, M., Sanghera, J., Yan, J., Rallis, C., Pinchin, S., McDonald, P.Hannigan, G. E., Foster, L. J., Ish-Horowicz, D., Walsh, M. P. and Dedhar,S. (2010) PLoS ONE: 5(8): e12356. Integrin-linked kinase is a bona fide serine-threonine protein kinase.

Walsh, M. P., Thornbury, K., Cole, W. C., Sergeant, G., Hollywood, M. and McHale, N. (2010) Am. J. Physiol.: in press(doi:10.1152/ajprenal.00011.2010). Rho-associated kinase plays a role in rabbit urethral smooth muscle contraction, but not via enhanced myosinlight chain phosphorylation.

Zhong, X. Z., Liao, C-H., Abd-Elrahman, K. S., El-Yazbi, A. F., Walsh, E. J., Walsh, M. P. and Cole, W. C. (2010) J. Physiol.: in press (doi:10.1113/jphysiol.2010.196618). Stromatoxin-sensitive,heteromultimeric Kv1.2/Kv9.3 channels contribute to myogenic control of cerebral arterial diameter.

Gui, Y., Zheng, X-L., Walsh, M. P., He, G., Jankowski, J. and Jankowski, V. (2010) Am. J. Physiol.: in press. Signaling mechanisms mediating Up4A-induced proliferation of human smooth muscle cells.

Consumption of diets high in prebiotic fiber or protein during growth influences the response to a high fat and sucrose diet in adulthood in rats Alannah D Maurer1,2, Lindsay K Eller1, Megan C Hallam2, Kim Taylor2, Raylene A Reimer1,2*

NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis. Hirota SA, Ng J, Lueng A, Khajah M, Parhar K, Li Y, Lam V, Potentier MS, Ng K, Bawa M, McCafferty DM, Rioux KP, Ghosh S, Xavier RJ, Colgan SP, Tschopp J, Muruve D, MacDonald JA, Beck PL. Inflamm Bowel Dis. 2010 Sep 24. [Epub ahead of print]

Shafa M, Krawetz R, and Rancourt DE. (2010) Returning to the Stem State: The Epigenetics of Recapitulating Pre-Differentiation Chromatin Structure. Bioessays 32: 791-9.

zur Nieden NI, Dacks LA, and Rancourt, DE. (2010) Comparing three novel endpoints for developmental osteotoxicity in the embryonic stem cell test. Toxicol Applied Pharmacol 247: 91-7.

Gao, Z., Monckton, E. A., Glubrecht, D. D., *Logan, C*. and Godbout, R. (2010). Early isoform of Disabled-1 functions independently of reelin-mediated tyrosine phosphorylation in chick retina. Mol. Cell. Biol. 30: 4339-53.

Anti-Scl-70 (topo-I) antibodies in SLE: Myth or reality? Mahler M, Silverman ED, Schulte-Pelkum J, Fritzler MJ. Autoimmun Rev. 2010 Sep;9(11):756-60. Epub 2010 Jun 22.

Predictors of interstitial lung disease in early systemic sclerosis: a prospective longitudinal study of the GENISOS cohort. Assassi S, Sharif R, Lasky RE, McNearney TA, Estrada-Y-Martin RM, Draeger H, Nair DK, Fritzler MJ, Reveille JD, Arnett FC, Mayes MD; the GENISOS Study Group. Arthritis Res Ther. 2010 Sep 2;12(5):R166. [Epub ahead of print]

 

August Publications

 

Zhong X.Z., Abd-Elrahman K.S., Liao C.H., El-Yazbi A.F., Walsh E.J., Walsh M.P. and Cole W.C. Stromatoxin-sensitive, heteromultimeric Kv2.1/Kv9.3 channels contribute to myogenic control of cerebral arterial diameter. JPhysiol. 2010 Sep 27

Walsh M.P., Thornbury K., Cole W.C., Sergeant G.P., Hollywood M. and McHale N.G. Rho-associated kinase plays a role in rabbit urethral smooth muscle contraction, but not via enhanced myosin light chain phosphorylation. Am JPhysiol Renal Physiol. 2010 Sep 22. [Epub ahead of print]

El-Yazbi A.F., Johnson R.P., Walsh E.J,. Takeya K., Walsh M.P. and Cole W.C. Pressure-dependent contribution of Rho kinase-mediated calcium sensitization in serotonin-evoked vasoconstriction of rat cerebral arteries. J Physiol. 2010 May15;588(Pt 10):1747-62.

Krawetz R, Taiani JT, Liu S, Meng G, Li X, Kallos MS, Rancourt DE. Large-scale expansion of pluripotent human embryonic stem cells in stirred-suspension bioreactors. Tissue Eng Part C Methods. 2010 Aug;16(4):573-82.

Alfred R, Gareau T, Krawetz R, Rancourt D, Kallos MS. Serum-free scaled up expansion and differentiation of murine embryonic stem cells to osteoblasts in suspension bioreactors. Biotechnol Bioeng. 2010 Aug 1;106(5):829-40.

Aalim M Weljie, Frank R Jirik. Hypoxia-induced metabolic shifts in cancer cells: moving beyond the Warburg effect. Int J Biochem Cell Biol. 2010 Aug 24. [Epub ahead of print]

 

 

July Publications

 

 

Tropomyosin-binding properties of the CHASM protein are dependent upon its calponin homology domain.Ulke-Lemée A, Ishida H, Borman MA, Valderrama A, Vogel HJ, Macdonald JA.FEBS Lett. 2010 584(15):3311-3316.

Increased plasma PYY levels following supplementation with the functional fiber PolyGlycopleX in healthy adults RA Reimer1, X Pelletier2, IG Carabin3, M Lyon4,5, R Gahler6, JA Parnell7 and S Wood4. European Journal of Clinical Nutrition (2010), 1-6

Attenuation in Weight Gain with High Calcium- and Dairy-Enriched Diets Is Not Associated with Taste Aversion in Rats: A Comparison with Casein, Whey, and Soy Lindsay K. Eller1 and Raylene A. Reimer1,2 J Med Food 13 (5) 2010, 1-7

A High Calcium, Skim Milk Powder Diet Results in a Lower Fat Mass in Male, Energy-Restricted,Obese Rats More Than a Low Calcium, Casein,or Soy Protein Diet1,2 Lindsay K. Eller3 and Raylene A. Reimer3,4*3 J Nutr 2010

Shafa M, Krawetz R, Rancourt DE.  Returning to the stem state: Epigenetics of recapitulating pre-differentiation chromatin structure. Bioessays. 2010 Jul 22. [Epub ahead of print] PMID: 20652894

Novel diagnostic and clinical aspects of anti-PCNA antibodies detected by novel detection methods.Mahler M, Silverman ED, Fritzler M. Lupus. 2010 Jul 20. [Epub ahead of print]PMID: 20647252 [PubMed - as supplied by publisher]

Anti-Scl-70 (topo-I) antibodies in SLE: Myth or reality? Mahler M, Silverman ED, Schulte-Pelkum J, Fritzler MJ. Autoimmun Rev. 2010 Jun 22. [Epub ahead of print]PMID: 20601198 [PubMed - as supplied by publisher]

Comparison between multiplex assays for autoantibody detection in systemic lupus erythematosus. Hanly JG, Su L, Farewell V, Fritzler MJ. J Immunol Methods. 2010 Jun 30;358(1-2):75-80. Epub 2010 May 9.PMID: 20438730 [PubMed - indexed for MEDLINE]

Mita, M., Kuramoto, T., Ito, K., Toguchi-Senrui, N., Hishinuma, S. ,Walsh, M. P. and Shoji, M. (2010) Clin. Exp. Pharmacol. Physiol. 37: 350-357. Impairment of a1-adrenoceptor-mediated contractile activity in caudal arterial smooth muscle from Type 2 diabetic Goto-Kakizaki rats.

Mita, M., Ito, K., Taira, K., Nakagawa, J., Walsh, M. P. and Shoji, M. (2010) Clin. Exp. Pharmacol. Physiol. DOI:10.1111/j.1440-1681.2010.05373.x. Attenuation of store-operated Ca2+ entry and enhanced expression of TRPC channels in caudal arterial smooth muscle of type 2 diabetic Goto-Kakizaki rats.

El-Yazbi, A. F., Johnson, R. P., Walsh, E. J., Takeya, K., Walsh, M. P. and Cole, W. C. (2010) J. Physiol. 588: 1747-1762. Pressure-dependent contribution of Rho kinase-mediated calcium sensitization in serotonin-evoked vasoconstriction of rat cerebral arteries. 

 

June Publications

 

Effect of prebiotic fibre supplementation on hepatic gene expression and serum lipids: a dose-response study in JCR:LA-cp rats Jill A. Parnell1 and Raylene A. Reimer2,3*

Comparison between multiplex assays for autoantibody detection in systemic lupus erythematosus. Hanly JG, Su L, Farewell V, Fritzler MJ. J Immunol Methods. 2010 Jun 30;358(1-2):75-80. Epub 2010 May 9.

 

Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma.

Palanisamy N, Ateeq B, Kalyana-Sundaram S, Pflueger D, Ramnarayanan K, Shankar S, Han B, Cao Q, Cao X, Suleman K, Kumar-Sinha C, Dhanasekaran SM, Chen YB, Esgueva R, Banerjee S, LaFargue CJ, Siddiqui J, Demichelis F, Moeller P, Bismar TA, Kuefer R, Fullen DR, Johnson TM, Greenson JK, Giordano TJ, Tan P, Tomlins SA, Varambally S, Rubin MA, Maher CA, Chinnaiyan AM. Nat Med. 2010 Jul;16(7):793-8. Epub 2010 Jun 6.

 

May Publications

 

Rybicka, J.M., Balce, D.R., Khan, M., Krohn, R.M., and Yates, R.M. (2010). NADPH oxidase activity controls phagosomal proteolysis in macrophages through modulation of the lumenal redox environment of phagosomes. Proc Nat Acad Sci USA.  [Epub ahead of print]<http://www.pnas.org/content/early/2010/05/13/0914867107.abstract

A. Ulke-Lemee and J.A. MacDonald. (2010) Venues for the development of kinase inhibitors to regulate smooth muscle contraction. Pharmaceuticals 3: 1739-1760.

P.L. Beck, E. Ihara, S.A. Hirota, J.A. MacDonald, D. Meng, N.N.Nanthakumar, D.K. Podolsky and R.J. Xavier. (2010) Exploring the Interplay of Barrier Function and Leukocyte Recruitment in Intestinal Inflammation by Targeting Fucosyltransferase VII and Trefoil Factor 3. Am J Physiol Gastrointest Liv Physiol. In press.

Residues Contributing to the Na⁺-binding Pocket of the SLC24 Na⁺/Ca²⁺-K⁺ Exchanger NCKX2 J. Biol. Chem. 2010 285: 15245-15255. First Published on March 15, 2010

Clinical and serological evaluation of a novel CENP-A peptide based ELISA Mahler M, Maes L, Blockmans D, Westhovens R, Bossuyt X, Riemekasten G, Schneider S,Hiepe F, Swart A, Gurtler I, Egerer K, Fooke M, Fritzler MJ. Arthritis Res Ther. 2010 May 20;12(3):R99. [Epub ahead of print]PMID: 20487535

Systemic sclerosis: establishing diagnostic criteria Hudson M, Fritzler MJ, Baron M; Canadian Scleroderma Research Group (CSRG).Medicine (Baltimore). 2010 May;89(3):159-65.PMID: 20453602 [PubMed - indexed for MEDLINE]

 

April Publications

 

Cho IR, Koh SS, Min HJ, Park EH, Ratakorn S, Jhun BH, Jeong SH, Yoo YH, Youn HD, Johnston RN, Chung YH (2010) Down-regulation of HIF-1a by oncolytic reovirus infection is independent of VHL and p53. Cancer Gene Therapy 17:365-72.

Park EH, Park EH, Cho IR, Srisuttee R, Min HJ, Oh MJ, Jeong YJ, Jhun BH, Johnston RN, Lee S, Koh SS, Chung YH. (2010) CUG2, a novel oncogene confers reoviral replication through Ras and p38 signaling pathway. Cancer Gene Therapy 17:307-14.

 Cho IR, Koh SS, Min HJ, Park EH, Srisuttee R, Jhun BH, Kang CD, Kim M, Johnston RN, Chung YH. (2010) Reovirus infection induces apoptosis of TRAIL-resistant gastric cancer cells by down-regulation of Akt activation. Int J Oncol 36:1023-30. 

Jiang, Y.L., Hao, Y. and Zheng, X.L. MicroRNA-1 Inhibits Myocardin-induced Contractility of Human Vascular Smooth Muscle Cells. Journal of Cellular Physiology 2010 [Epub ahead of print].

Yin, H., Gui, Y., Du, G., Frohman, M.A. and Zheng, X.L. Dependence of phospholipase D1 multi-monoubiquitination on its enzymatic activity and palmitoylation. Journal of Biological Chemistry 2010 285(18): 13580-8 

Yin, H., Gui, Y. and Zheng, X.L. 2-Methoxyestradiol inhibition of atorvastatin-induced rounding of human vascular smooth muscle cells: a mechanism for gender-dependent effects of statins. Journal of Cellular Physiology 2010 222 (3): 556-564 

Hammel M, Yu Y, Mahaney BL, Cai B, Ye R, Phipps BM, Rambo RP, Hura GL, Pelikan M, So S, Abolfath RM, Chen DJ, Lees-Miller SP, Tainer JA. Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex.J Biol Chem. 2010 Jan 8;285(2):1414-23.

Douglas P, Zhong J, Ye R, Moorhead GB, Xu X, Lees-Miller SP. Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX. Mol Cell Biol. 2010 Mar;30(6):1368-81.

Williamson CT, Muzik H, Turhan AG, Zamò A, O'Connor MJ, Bebb DG, Lees-Miller SP. ATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors. Mol Cancer Ther. 2010 Feb;9(2):347-57.

Clostridium difficile toxin-induced inflammation and intestinal injury are mediated by the inflammasome.Ng J, Hirota SA, Gross O, Li Y, Ulke-Lemee A, Potentier MS, Schenck LP, Vilaysane A, Seamone ME, Feng H, Armstrong GD, Tschopp J, Macdonald JA, Muruve DA, Beck PL.Gastroenterology. 2010 Apr 13. [Epub ahead of print] PMID: 20398664 [PubMed - as supplied by publisher]

Hypoxia-inducible factor signaling provides protection in Clostridium difficile-induced intestinal Injury.Hirota SA, Fines K, Ng J, Traboulsi D, Lee J, Ihara E, Li Y, Willmore WG, Chung D, Scully MM, Louie T, Medlicott S, Lejeune M, Chadee K, Armstrong G, Colgan SP, Muruve DA, Macdonald JA, Beck PL. Gastroenterology. 2010 Mar 25. [Epub ahead of print]PMID: 20347817 [PubMed - as supplied by publisher]