DR. JEROME B. RATTNER

B.Sc. (Miami, Oxford, Ohio), M.Sc. (Texas), Ph.D. (Irvine) - Professor, Departments of Cell Biology & Anatomy, Biochemistry & Molecular Biology and Oncology; Staff Member, Tom Baker Cancer Centre.

Affiliations: Member - Alberta Bone and Joint Health Institute

Research Interests:

The focus of my laboratory is the study of proteins that are involved in cell division. These include proteins of the kinetochore, nucleolus and nucleolus organizer, centrosome and mitotic spindle. Many of these proteins are identified because they act as antigens in human autoimmune disease. One outcome of our studies has been the identification of antigens that can be used as diagnostic markers in diseases such as human autoimmune disease and cancer.

Personnel:

Recent Publications:

• Salina, D., Bodoor, K., Eckley, D., Schroer, T., Rattner, J.B. and Burke, B. (2002) Cytoplasmic Dynein as a Facilitator of Nuclear Envelope Breakdown Cell 108:97-107.
• Ou, Y., Mack, G., Zhang, M., Rattner, J.B. (2002) A domain associated with centrosome maturation within the tubular structure of the centrosome. J. Cell Science 115:825-835.
• Ou, Y. and Rattner, J.B. (2002) Post-karyokinesis centrosome movement leaves a trail of unanswered questions. Cell Motility and Cytoskeleton 51(3):123-132.
• Lo, I.K.Y., Chi, S., Frank, C.B. and Rattner, J.B. (2002) The cellular matrix: A feature of tensile bearing dense soft connective tissues. Histology and Histopathology 17(2):523-537.
• Lo, I.K.Y., Yong, O., Rattner, J.P., Hart, D.A., Marchuk, L., Frank, C.B. and Rattner, J.B. (2002) The cellular networks of normal ovine medial collateral and anterior cruciate ligaments are not accurately recapitulated in scar tissue. Journal of Anatomy 200(3)283-296.
• Bruehlmann, S.B., Rattner, J.B., Matyas, J.R. and Duncan, N.A. (2002) Regional variations in the cellular matrix of the annulus fibrosus of the intervertebral disc. (J. Anatomy, in press).
• Hellio Le Graverand, M, Ou, Y, Shield-Yee, T, Barclay, L, Hart, D, Natsume, T and Rattner, J.B. (2001) The cells of the rabbit meniscus: their arrangement, interrelationship, morphological variations and cytoarchitecture. J. Anat. 198:525-535.
• Hellio Le Graverand, M, Sciore, P, Eggerer, J, Rattner,J.P., Vignon, E, Barclay, L, Hart, D.A., Rattner, J.B. (2001) Formation and Phenotype of Cell Clusters in Osteoarthitic Meniscus. Arthritis & Rheumatism 44(8):1808 - 1818.
• Muldrew, K, Chung, M, Novak, K, Schachar, N.S. , Zernicke, R.F., McGannt, L.E., Rattner, J.B. and Matyas, J.R. (2001) Evidence of chondrocyte repopulation in adult ovine articular cartilage following cryoinjury and long-term transplantation.Osteoarthritis and Cartilage  9: 432 - 439.
• Shimoni, Y. and Rattner, J.B. (2001) Type 1 diabetes leads to cytoskeleton changes that are reflected in insulin action on rat cardiac K+ currents.  Am J. Physiol. Endocrinol. Metabl. 281:E575-E585.

Contact Information:

The University of Calgary,
Room 434 Heritage Medical Research Building,
3330 Hospital Drive NW, Calgary, Alberta
Canada T2N 4N1
Phone (403) 220-4478
Fax: (403) 283-8731
E-mail: rattner [at] ucalgary [dot] ca.