DR. GEORGE CHACONAS

Professor, Department of Biochemistry & Molecular Biology and Microbiology & Infectious Diseases (MID), Alberta Heritage Foundation for Medical Research Scientist

 Personnel:

Recent Publications:

• Chaconas, G. and Kobryn, K. (2010) Structure, Function and Evolution of Linear Replicons in Borrelia, Annual Review of Microbiology, in press.
• Tourand, Y., Deneke, J, Moriarty, T.J. and Chaconas, G. (2009) Characterization and in vitro reaction properties of 19 unique hairpin telomeres from the linear plasmids of the lyme disease spirochete. J. Biol. Chem. 284, 7264-7272.
• Chaconas, G. (2009) Replication of B. burgdorferi DNA and scrambling of the linear replicons through reverse telomere resolution, in Borrelia: Molecular Biology, Host Interaction and Pathogenesis. Edited by D. Scott Samuels and Justin Radolf, Horizon Scientific Press, Norwich, UK. in press.
• Lefas, G. and Chaconas, G. (2009) High throughput screening identifies three inhibitor classes of the telomere resolvase from the lyme disease spirochete. Antimicrobial Agents and Chemotherapy, http://aac.asm.org/cgi/reprint/AAC.00529-09v1?view=long&pmid=19596868
• Moriarty, T.J. and Chaconas, G. (2009) Identification of the determinant conferring permissive substrate usage in the telomere resolvase, ResT. J. Biol. Chem., http://www.jbc.org/cgi/reprint/M109.023549v1?view=long&pmid=19561077
• Dresser AR, Hardy P-O, Chaconas G, 2009 Investigation of the Genes Involved in Antigenic Switching at the vlsE Locus in Borrelia burgdorferi: An Essential Role for the RuvAB Branch Migrase. PLoS Pathogens 5(12): e1000680. doi:10.1371/journal.ppat.1000680
• Lee, W.Y., Moriarty, T.J., Wong, C.H., Zhou, H., Strieter R., Chaconas, G. and Kubes, P. (2010) Intravascular Antigen Presentation: an Invariant NKT Cell-Kupffer Cell Encounter. Nature Immunology, 11, 295-302. 
• Chaconas, G. (2009) Replication of B. burgdorferi DNA and scrambling of the linear replicons through reverse telomere resolution, in Borrelia: Molecular Biology, Host Interaction and Pathogenesis. Edited by D. Scott Samuels and Justin Radolf, pp. 55-66, Horizon Scientific Press, Norwich, UK.

Contact Information:

The University of Calgary
272B Heritage Medical Research Building
Phone: (403) 210-9692
Fax: (403) 270-2772
Email: Chaconas [at] ucalgary [dot] ca