DR. HANS J. VOGEL

Ph.D. (Alberta) - Professor, Department of Biological Sciences and Adjunct Professor, Department of Biochemistry & Molecular Biology; Director, Bio-NMR Facility; AHFMR  Scientist.

Research Interests :

• 1) Protein-protein interactions of regulatory calcium-binding proteins in mammals and plants are studied by NMR spectroscopy and biophysical methods.
• 2) Structural and dynamic studies of bacterial iron uptake and fatty acid biosynthesis as potential targets for the development of new classes of antibiotics.
• 3) Mechanism of action of antimicrobial peptides and host defense proteins. Development of novel peptide- or protein-based bactericidal and bacteriostatic compounds.
• 4) Metabolomics studies of infectious and inflammatory diseases; studies of antibiotic action and sepsis in animal models and humans.

Dr. Vogel's Web Page

Graduate Students

   Mauricio Arias, M.Sc.
Byron Chu, M.Sc.
Gavin Duggan, B.Sc.
Jessica Gifford, B.Sc.
Mostafa Jamshidiha, M.Sc.
Evan Haney, B.Sc.
Hao Huang, M.Sc.
Cheryl Lau, B.Sc.
Subrata Paul, M.Sc.
Anton Skorobogatov, B.Sc.

Postdoctoral Fellows and Research Associates:

Hiroaki Ishida, Ph.D., Research Associate
Ted Johanson, Ph.D., Postdoctoral Fellow
Zhihong Liu, Ph.D., Postdoctoral Fellow
Leo Nguyen, Ph.D., Postdoctoral Fellow
Rustem Shaykhutdinov, Ph.D., Research Associate
Aalim Weljie, Ph.D., Research Associate

View Pub Med for Recent publications & abstracts

Recent Publications:

• Chan, D.I., Tieleman, D.P. and Vogel, H.J. (2010) "Molecular dynamics studies of beta-ketoacyl, beta-hydroxyacyl and trans-2-enoyl Acyl Carrier Protein of Escherichia coli"  Biochemistry 49: 2860-2868.
• Otten, R., Chu, B., Krewulak, K.D., Vogel, H.J. and Mulder, F.A.A. (2010) "Comprehensive and cost-effective NMR spectroscopy of methyl groups in large proteins"  J. Am. Chem. Soc. 132: 2952-2960.
• Nguyen L.T., Chan, I.D., Boszhard, L., Zaat, S.A.J. and Vogel, H.J. (2010) "Structures and antimicrobial activities of chemokine-derived carboxy-terminal helical peptides" Biochem. Biophys. Acta - Biomembranes 1798: 1062-1072.
• Haney, E.F. and Vogel, H.J. (2009) "NMR studies of antimicrobial peptides" Annu. Reports NMR Spectroscopy 65:1-51.
• Yamniuk, A.P., Ishida, H., Lippert, D., and Vogel, H.J. (2009).  "Thermodynamic effects of non-coded and coded methionine-substitutions in calmodulin" Biophys. J. 96: 1495-1507.
• Lopez, C.S., Peacock, R.S., Crosa, J.H. and Vogel, H.J. (2009).  "Molecular characterization of TonB2 from the fish pathogen Vibrio anguilarum"  Biochem J. 418: 49-59.
• Wishart, D.S., Knox, C., 25 coauthors, Nazyrova, A, Shaykhutdinov, R, Li, L. and Vogel, H.J. and Forsythe, I. (2009) "HMDB: a knowledgebase for the human metabolome" Nucleic Acids Res. 37: D603-D610.
• Pushie, M.J., Rauk, A., Jirik, F. and Vogel, H.J. (2009) "Can copper binding to the prion protein generate a misfolded form of the protein?" Biometals 22: 159-175.
• Yamniuk, A.P., Burling, H. and Vogel, H.J. (2009).  "Thermodynamic characterization of the interactions between osteopontin and lactoferrin" Mol. Immunol.  46: 2395-2402.
• Ishida, H, Rainaldi, M. and Vogel, H.J. (2009) "Structural analysis of soybean calmodulin isoform-4 complexed with MAPK-phosphatase-1 provides insight into a unique sequential target-binding mode" J. Biol. Chem. 284: 28292-28305.
• Llamas, M.A., vanderSar, A., Chu, B.C., Sparrius, M., Vogel, H.J. and Bitter, W. (2009) "A novel extracytoplasmic function (ECF) sigma factor regulates virulence in Pseudomonas aeruginosa"  Plos Pathog. 5 (9): e1000572.
• Yamniuk, A.P., Gifford, J.L., Linse, S. and Vogel, H.J. (2008).  "The effects of metal binding loop mutations on ligand-binding to the calcium- and integrin-binding protein 1:  Evolution of  the EF-hand?"  Biochemistry 47: 1696-1707.
• Chan, D.I., Hunter, H.N., Tack, B.F. and Vogel, H.J. (2008).  "Human macrophage inflammatory protein 3alpha:  solution structure, dimerization and anti-infective properties"  Antimicrob. Agents Chemother. 52: 883-894.
• Ishida, H., Huang, H., Yamniuk, A.P., Takaya, Y. and Vogel, H.J. (2008).  "The solution structures of two soybean calmodulin isoforms and their relationship to selective target-activation properties"  J. Biol. Chem. 283: 14619-14628.
• Ishida, H., Borman, M.A., Ostrander, J., Vogel, H.J. and MacDonald, J.A. (2008).  "Solution structure of the calponin homology (CH)-domain from smoothelin-like 1 protein:  a unique apo-calmodulin binding mode"  J. Biol. Chem. 283: 20569-20578.
• Pushie, M.J. and Vogel, H.J. (2008).  "Modeling by assembly and molecular dynamics of the low Cu²⁺ occupancy form of the mammalian prion protein octarepeat region:  gaining insight into Cu²⁺-mediated beta-cleavage"  Biophys. J. 95: 5084-5091.
• Chan, D.I., Stockner, T., Tieleman, D.P., and Vogel, H.J. (2008).  "Molecular dynamics simulations of apo-, holo- and acyl- forms of Escherichia coli acyl carrier protein"  J. Biol. Chem.  283: 33620-33629.
• Weljie, A.M., Newton, J., Jirik, F.R. and Vogel, H.J. (2008).  "Incorporating signals of unknown compounds in quantitative mixture analysis"  Anal. Chem. 80: 8956-8965.

Contact Information:

The University of Calgary,
Room 423 Biological Sciences,
2500 University Drive NW, Calgary, Alberta
Canada T2N 1N4
Phone (403) 220-6006
Fax: (403) 289-9311
E-mail: vogel [at] ucalgary [dot] ca