DR. FLOYD F. SNYDER

B.Sc. (Calgary), M.Sc. (McMaster), Ph.D. (Alberta), FCCMG - Professor, Department of Medical Genetics and Emeritus Professor, Biochemistry & Molecular Biology, and Adjunct Professor, Department of Biological Sciences; Director, Biochemical Genetics Lab, Alberta Children's Hospital.

Affiliations:  Member - Population Genomics Research Group.

Research Interests:

My research interests are in the metabolic and molecular basis of inherited disease. A mouse model of purine nucleoside phosphorylase (PNP) deficiency has been developed that reveals a progressive numerical deficit in T cells and apparent block in thymocyte differentiation. Ongoing work is directed to understanding the molecular mechanisms of the disruption in T cell differentiation and exploring novel therapeutic strategies. Other studies have focused on the genetic regulation of cellular GTP pools and we have recently cloned the human gene for guanine deaminase. Further studies using transgenic mice are directed towards the introduction of genes encoding novel catalytic functions that will create two new metabolic cycles which we believe will prove beneficial in the treatment of metabolic disease and malignancy. To this end, we have engineered a novel mammalian enzyme, adenosine phosphorylase, by site-directed modification of purine nucleoside phosphorylase.

 

 

 

Personnel:

Hong Zhang	Research Associate
Ken Sherley	Technician
Bridgette Fera	Adminstrative Assistant

 

 

 

View Pub Med for Recent publications & abstracts

Recent Publications:

• McLeod, D.R, Snyder, F., Bridge, P., Pinto, A.  Acute hemorrhagic leukoencephalitis in male sibs.  Am. J. Med. Genetics  107:325-329, 2002.
• Giese, R.D. and Snyder F.F. cDNA sequence of five mouse guanine deaminase, (Gda) alleles and mapping to mouse chromosome 19. Genome  45:276-281, 2002.  
• Nezarati, M.M., Loeffler, J., Yoon, G., MacLaren, L., Fung, E., Snyder, F., Utermann, G., Graham, G.E. Novel mutation in the Delta-sterol reductase gene in three Lebanese siblings with the Smith-Lemli-Opitz (RSH) Syndrome.  Am. J. Med. Genetics  110:103-108, 2002.
• E. Hyndman, B. Manns, F.F. Snyder, P. Bridge, N. Scott-Douglas, E. Fung, H. Parsons. Supplementation with Vitamin B12 decreases but does not normalize homocysteine and methylmalonic acid in end-stage renal disease: a possible link with glycine metabolism. Metabolism,  in press.
• Lee J. Brewerton, Ernest Fung and Floyd F. Snyder. Production and properties of polyethylene glycol conjugated adenosine phosphorylase: administration to purine nucleoside phosphorylase deficient mice. Biochimica et Biophysica Acta, submitted.
• J.T. Maynes, R.G. Yuan, B.M. Phipps, S.A. Lister, K. Leung, and F.F. Snyder. (2001). Further refinement on the engineering of adenosine phosphorylase from purine nucleoside phosphorylase. In: Purine and Pyrimidine Metabolism in Man X, eds. Zoref-Shani and Sperling, Kluwer Academic/Plenum Publishers (2000), pp. 107-110.
• F.F. Snyder, R.G. Yuan, J.C. Bin, K.L. Carter, and Don J. Mc (2001). Kay. Human guanine deaminanse: cloning, expression and characterisation.  In:  Purine and Pyrimidine Metabolism in Man X, eds. Zoref-Shani and Sperling, Kluwer Academic/Plenum Publishers (2000), pp. 111-114.
• Manns B, Hyndman E, Burgess E, Parsons H, Schaefer J, Snyder F, Scott-Douglas N. (2001). Oral vitamin B12 and high dose folic acid in hemodialysis patients with hyperhomocysteinemia: a double blind randomized clinical trial. Kidney International  59:1103-9.
• Maynes J.T., Yuan R.G., Snyder F.F. Identification, expression, and characterization of Escherichia coli guanine deaminase. J. Bacteriol. 182:4658-4660, 2000.

Contact Information:

The University of Calgary,
Room 2123 Health Sciences Centre,
3330 Hospital Drive NW, Calgary,
Alberta Canada T2N 4N1
Phone (403) 220-6025
Fax: (403) 283-4740
E-mail: snyder [at] ucalgary [dot] ca.