DR. NAVNEET SHARMA

B.Sc. and M.Sc. Molecular Biology & Biochemistry (GND University, India), Ph.D. Molecular Biology and Biochemistry (RRL Jammu-Council of Scientific and Industrial Research and GND University, India) Adjunct Lecturer - Department of Biochemistry and Molecular Biology, Coordinator - Biotechnology Business Aspects (Master's in Biomedical Technology Program) - http://www.biotech.ucalgary.ca/faculty.html

Research Interests:

Proteases are known to play a critical role in different physiological and pathological processes. There are different types of proteinases based on their characteristics mainly general specificity of substrates. Some of the proteases are well defined with respect to their substrates and specificities but many of them are still poorly characterized. Different proteomic approaches have been developed to address these issues complimented by Structural genomics approaches.

We are interested in the ‘Characterization of the specificity and identification of putative substrates of these proteases by employing bacteriophage display of small peptides.' Presently we are working on determining the substrate specificities of Implantation Serine Proteinases (ISP1 and ISP2), novel serine proteinases characterized from the uterine endometrium and early stage embryos by Derrick Rancourt lab) and Human Kallikreins  in collaboration with Prof. Eleftherios Diamandis, Mount Sinai Hospital, Toronto. We are looking forward to work with many more poorly characterized proteinases. Any queries for collaborating in this regard are welcome.

View Pub Med for Recent publications & abstracts

Recent Publications:

• 1. Sharma, N., Kumar, R., Renaux, B., Saifeddin, M., Nishikawa, S., Ramachandran, R., Hollenberg, MD. and Rancourt, D. ‘Implantation Serine Proteinase 1 shows mixed substrate specificity and can silence the signalling through Proteinase Activated Receptors' in preparation
• 2. Sharma, N., Oikonomopoulou, K., Ito, K., Renaux, B., Diamandis, E. and Hollenberg, M. Rancourt, D., ‘Substrate specificity determination of Implantation Serine Proteinase complex and Human Kallikrein 6 (KLK6) by the phage display' Biological Chemistry (2008) 389 (8)
• 3. Sharma, N., Kaur, J., Xu, H., Zur Nieden, N. & Rancourt, D. ‘Characterization of Secretory Leukocyte Proteinase Inhibitor (SLPI) as an inhibitor of Implantation Serine Proteinase' Molecular Reproduction and Development (2008) 75 (7) 1136-1142
• 4. Sharma, N., Liu, S., Tang, L., Irwin, J., Meng, G. & Rancourt, D. ‘Implantation serine proteinases heterodimerize and are critical in hatching and implantation' BMC Developmental Biology (2006) 6(1), 61
• 5. Sharma N. and Qazi G. N. ‘Inhibition of glucose oxidation in Erwinia herbicola by a high concentration of dissolved Oxygen' World J. Microbiology & Biotechnology  (1994) 10, 313-319
• 6. Qazi, G.N., Sharma, N. & Parshad, R. ‘Role of dissolved oxygen as a regulator for the direct oxidation of glucose by Erwinia herbicola & Gluconobacter oxydans' Journal of Fermentation & Bioengineering (1993) 76(4), 336-339
• 7. Sharma, N., Parshad, R. & Qazi, G.N. ‘Electron transport system associated with direct glucose oxidation in Gluconobacter oxydans' Biotechnology Letters (1992) 14(5), 391-396
• 8. Buse, R., Onken, U., Qazi, G.N., Sharma, N., Parshad, R. & Verma, V. ‘Influence of dilution rate & dissolved oxygen concentration on the keto-acid production by Gluconobacter oxydans subsp. Melanogenus' Enzyme Microbial Technology (1992), 14(12), 1001-1006

Contact Information:

The University of Calgary, 
 Room B019, Health Science Building
3280 Hospital Drive NW
Canada T2N 4Z6
403-220 5011 (office)
403-220 4202 (lab) 
Fax: (403) 270-0834
E-mail :navsharm [at] ucalgary [dot] ca