DR. JOHN GILLEARD

BVSc, PhD, DipEVPC, MRCVS

  

Research Interests:

Our  main research interest is focused on understanding the molecular basis of drug (anthelmintic) resistance in parasites and in the identification of novel drug targets. We are currently interested in how nematodes metabolize drugs and the potential role of such mechanisms in drug resistance. Our research undertakes genomic and genetic approaches with  both parasites and the free-living nematode Caenorhabditis elegans as a model system. The lab also has projects involving  the population genetics, molecular epidemiology and molecular diagnostics of parasitic nematodes. Please visit the lab web page for further details.

Click here to go to the Gilleard website

Personnel:  

Umer Naveed Chaudhary	Graduate Student
Dr Alexander Eberhardt	PDF
Sai Ravikumar	Research Assistant
Dr. Yang Hyun-Jong	Visiting Scientist
Carrie Peterson	Administrative Assistant

 

 

 

 

 

View Pub Med for Recent publications & abstracts

Recent Publications:

• Redman,E., Grillo, V., Saunders, S., Packard E., Jackson F., Berriman,M., and  Gilleard J.S (2008) Genetics of mating and sex determination in the parasitic nematode Haemonchus contortus Genetics, 2008 Dec;180(4):1877-87
• Grillo V, Craig B, Wimmer,B.H and Gilleard J.S., (2008) Microsatellite genotyping supports the hypothesis that Teladorsagia davtiani and Teladorsagia trifurcata are morphotypes of Teladorsagia circumcincta.Molecular and Biochemical Parasitology, 159(1):59-63
• Redman, E., Packard, P. Grillo,V., Smith, J.,  Jackson, F. and  Gilleard J.S  (2007). Microsatellite analysis reveals marked genetic differentiation between Haemonchus contortis laboratory isolates and provides a rapid system of genetic fingerprinting. International Journal for Parasitology, 38, 111-122.
• Gilleard, J.S. and Beech R.N. (2007). Population genetics of anthelmintic resistance. Parasitology, 134, (Pt 8), 1133-47
• Grillo,V, Jackson F, Cabaret, J and Gilleard, J.S (2007). Population genetic analysis of the ovine parasitic nematode Teladorsagia circumcinta and evidence for cryptic speciation. International Journal for Parasitology, 37(3-4), 435-47
• Gilleard J.S. (2006) Understanding anthelmintic resistance: the need for genomics and genetics. International Journal for Parasitology, 36(12), 1227-39.
• Grillo,V, Jackson,F and Gilleard J.S. (2006) Characterisation of Teladorsagia circumcincta
  microsatellites and their development as population genetic markers. Molecular and Biochemical Parasitology, 148, (2), 181-189.
• Geldhof P, Murray L,  Couthier A, Gilleard, J.S  McLauchlan G, Knox DP and Britton C (2006) Testing the efficacy of RNA interference in Haemonchus contortus International Journal for Parasitology, June,
  36(7) 801-10
• Smith, JA, McGarr P and Gilleard J.S (2005). The Caenorhabditis elegans GATA factor elt-1 is essential for differentiation and maintenance of hypodermal seam cells and for normal locomotion. Journal of Cell Science. Dec 15;118(Pt 24):5709-19.
• Gilleard J.S , Woods, DJ, Dow, JA (2005) Model-organism genomics in veterinary parasite drug-discovery. Trends Parasitol. Jul;21(7):302-5.

 

Contact Information:

Dept. of Comparative Biology and Experimental Medicine,
Faculty of Veterinary Medicine
Department of Biochemistry and Molecular Biology,
Faculty of Medicine
3330, Hosptial Drive NW,
Calgary, Alberta, Canada
Tel; (403) 210 6327
 Fax: (403) 210 6693
email: jsgillea [at] ucalgary [dot] ca