Selected Recent Publications

 

1. Newton, R., Holden, N.S., Catley, M.C, Oyelusi, W., Leigh, R., Proud, D., Barnes, P.J. Repression of inflammatory gene expression in human pulmonary epithelial cells by small molecule IkB kinase (IKK) inhibitors. J. Pharmacol. Exp. Ther. 321:734-742, 2007.

2. Ayer, L. M., Wilson, S.A., Traves, S.L., Proud, D., Giembycz, M.A. RO1138542 is a selective, psudo-irreversible orthosteric antagonist at the prostacyclin (IP)-receptor expressed by human airway epithelial cells: negative IP-receptor-mediated regulation of CXCL9 and CXCL10 release. J. Pharmacol. Exp. Ther. 324:815-826, 2008.

3. Leigh, R., Oyelusi, W., Wiehler, S., Koetzler, R., Zaheer, R., Newton, R., Proud, D. Human rhinovirus infection enhances airway epithelial cell production of growth factors involved in airway remodeling. J. Allergy Clin. Immunol. 121:1238-1245, 2008.

4. Proud, D., Turner, R.B., Winther, B., Wiehler, S., Tiesman, J.P., Reichling, T.D., Juhlin, K.D., Fulmer, A.W., Ho, B.Y., Walanski, A.A., Poore, C.L., Mizoguchi, H., Jump, L., Moore, M.L., Zukowski, C.K., Clymer, J.W. Gene expression profiles during in vivo human rhinovirus infection: insights into the host response. Am. J. Respir. Crit. Care Med. 178:962-968, 2008.

5. Koetzler, R., Zaheer, R.S., Wiehler, S., Holden, N.S., Giembycz, M.A., Proud, D. Nitric oxide inhibits human rhinovirus-induced transcriptional activation of CXCL10 from airway epithelial cells. J. Allergy Clin. Immunol. 123:201-208, 2009.

6. Zaheer, R.S., Koetzler, R., Holden, N.S., Wiehler, S., Proud, D. Selective transcriptional down-regulation of human rhinovirus-induced production of CXCL10 from airway epithelial cells via the MEK1 pathway. J. Immunol. 182:4854-4864, 2009.

7. Koetzler, R., Zaheer, R.S., Newton, R., Proud D. Nitric oxide inhibits interferon regulatory factor-1 and nuclear factor-kB in rhinovirus infected epithelial cells. J. Allergy Clin. Immunol. 124:551-557, 2009.

8. Wilson, S.A., Shen, P., Rider, C.F., Traves, S.L., Proud, D., Newton, R., Giembycz, M.A. Selective prostacyclin receptor agonism augments glucocorticoid-induced anti-inflammatory gene expression in human bronchial epithelial cells. J. Immunol. 183:6788-6799, 2009.

9. Tacon, C.E., Wiehler, S., Holden, N., Newton, R., Proud, D., Leigh, R. Human rhinovirus infection of airway epithelial cells upregulates MMP-9 production via NF-kB. Am. J. Respir. Cell Mol. Biol. (in press).

10. Hudy, M.H., Traves, S.L., Wiehler, S., Proud, D. Cigarette smoke modulates rhinovirus-induced airway epithelial cell chemokine production. Eur. Respir. J. (in press).

11. Kelly, M.M., O'Connor, T.M., Leigh, R., Otis, J., Gwodz, C., GAuvreau, G.M., Gauldie, J., O'Byrne, P.M. Effects of budesonide and formoterol on allergen-induced airway responses, inflammation and airway remodeling in asthma. J. Allergy Clin. Immunol. (in press).